Phase 2 N=32 Intradiscal rhGDF-5 Phase I/II Clinical Trial
Degenerative Disc Disease
Primary: Neurological Assessment for Motor Function and Reflexes/Sensory — 0; 0 participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=178 Lumbar Degenerative Disc Disease Treated With Anterior Tension Band System (ATB) With ALIF/FRA Spacer
Lumbar Degenerative Disc Disease
Primary: Number of Subjects With Successful Radiographic Fusion — 90 Participants
N/A N=184 Understanding Non-Response in Spine Fusion Surgery
Spine Fusion
Primary: Oswestry Disability Index — 41.3; 30.4; 19.4 score on a scale
N/A N=231 Outcome Study of Patients Treated With Translational Cervical Plate Used to Treat Degenerative Disc Disease
Degenerative Disc Disease
Primary: Radiographic Fusion — 66; 46; 37; 75 percentage of subjects
N/A N=59 Benefit of Lumbar Bracing for Chronic Low Back Pain Due to Degenerative Disc Disease
Degenerative Disc Disease · Lumbar Spondylosis · Low Back Pain
Primary: Pain Diary — 6.71; 5 units on a scale
Phase 2 N=24 Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV)
Degenerative Disc Disease · Intervertebral Disc Disease · Low Back Pain
Primary: Pain and Disability Evaluation — 0.28; 0.15 scores from 0 to 1
N/A N=376 Activ-L™ Artificial Disc Treatment of Degenerative Disc Disease in the Treatment of Degenerative Disc Disease
Degenerative Disc Disease
Primary: Overall Success at 24 Months Relative to Baseline — 42.2; 28.3; 61.9; 52.8 percentage of participants — p=<0.05
N/A N=196 Efficacy of Acupuncture for Lumbar Spinal Stenosis
Lumbar Spinal Stenosis · Intermittent Claudication
Primary: The Change in Modified Roland-Morris Disability Questionnaire (RMDQ) Score From Baseline — -4.3; -3.0 score on a scale
N/A N=248 Postoperative Management for Degenerative Spinal Conditions
Spinal Degenerative Disorder
Primary: Oswestry Disability Index (ODI) — 43.6; 45.46; 31.31; 31.19 units on a scale
Phase 4 N=146 Herniectomy Versus Herniectomy With a Spinal Stabilization System for the Treatment of Complex Disc Disease
Sciatica · Back Pain
Primary: To Demonstrate a Statistically Significant Difference in the Relief of Back Pain Between Both Treatment Groups. The Endpoint Will be the Difference Between Baseline and…
N/A N=337 5-Year Global Study on MAST™ Minimally Invasive Fusion Procedures to Treat Degenerative Lumbar Spine (MASTERS-D2)
Intervertebral Disc Degeneration
Primary: Change (Preop-postop) of Disability, Oswestry Disability Index (ODI) at 3 Months as Compared to Baseline in DDD Patients With Spondylolisthesis — 23.19; 26.08 change of…
Phase 2 N=24 A Multicenter, Randomized, Double-blind, Placebo Controlled, Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of 2 Doses of Intradiscal rhGDF-5 (Single Administration) for the Treatment of Early Stage Lumbar Disc Degeneration
Degenerative Disc Disease
Primary: Neurological Assessment for Motor Function and Reflexes/Sensory — 0; 0 participants
Phase 2 N=31 A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration
Early Lumbar Disc Degeneration
Primary: Neurological Assessment for Motor Function and Reflexes/Sensory — 0; 0 participants
N/A N=575 LDR Spine USA Mobi-C(R) Cervical Disc Prosthesis IDE
Degenerative Disc Disease
Primary: Composite Definition of Study Success — 65.3; 73.7; 37.4; 69.7 percentage of subjects analyzed — p=0.0021
Phase 2 N=40 A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration
Early Lumbar Disc Degeneration
Primary: Neurological Assessment for Motor Function and Reflexes/Sensory — 0; 2 participants
N/A N=30 Trial Evaluating the Safety and Effectiveness of NUBAC™ Disc Arthroplasty
Degenerative Disc Disease
Primary: Participants With Improved Patient Function — 7; 6 participants — p=1.0
N/A N=75 Gait in Low Back Pain Patients After Spinal Mobilization
Chronic Low Back Pain
Primary: Change in the Numerical Pain Rating Scale — 5.96; 6.12; 6; 1.22 units on a scale
Phase 3 N=545 Study of Safety & Effectiveness of PRESTIGE® LP Cervical Disc vs. Anterior Cervical Fusion in Cervical DDD
Cervical Degenerative Disc Disease
Primary: Rate of Overall Success — 70.4; 63.2 percentage of participants — p=0.995
N/A N=259 Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)
Lumbar Spinal Stenosis
Primary: Swiss Spinal Stenosis (SSS) Questionnaire Score — -2.0; -1.7; -4.1 units on a scale — p=0.73
N/A N=267 Investigation of the Simplify® Cervical Artificial Disc
Cervical Degenerative Disc Disease
Primary: Number of Participants With Composite Clinical Success (CCS) of Simplify Disc — 68; 132 Participants — p=<.001
N/A N=20 Study to Evaluate the Effectiveness of DRG Stimulation for Discogenic Low Back Pain
Chronic Pain
Primary: Percentage of Subjects With 30% or Greater Reduction in Back Pain at 6 Months — 11 Participants
N/A N=15 Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® Disc Augmentation System: A Pilot Study
Low Back Pain
Primary: Numbers and Types of Adverse Events (Only Number of Events is Reported in This Section - See Adverse Events Section for Further Detail) — 17 Events
N/A N=500 Comparison of DISCOVER™ Artificial Cervical Disc and ACDF for Treatment of Cervical DDD (IDE Study)
Cervical Degenerative Disc Disease
Primary: Overall Success — 137; 110; 28; 13 participants who are successes
N/A N=1,674 Postmarket Registry for Evaluation of the Superion® Spacer
Lumbar Spinal Stenosis
Primary: Vertiflex® Patient Satisfaction Survey — 1147 Participants
N/A N=100 Sagittal Plane Shear Index for Planning Lumbar Stenosis Surgery
Lumbar Spinal Stenosis · Spondylolisthesis
Primary: Proportion of Surgical Plans Recorded Prior to the SPSI Report That Are Altered After Integration of SPSI Into the Surgical Planning — 47; 22; 6 Surgical plans
N/A N=20 TRIUMPH Lumbar Artificial Disc IDE: A Pilot Study
Lumbar Degenerative Disc Disease
Primary: Number of Participants With a Change of at Least 15 Points in Pain/Disability Using the Oswestry Disability Index (ODI) Score at 24 Months Compared With the Score at…
N/A N=20 Clinical and Radiological Evaluation of Patients With DDD Following TLIF With 3-D Printed Titanium Cage
Intervertebral Disc Disease
Primary: Fusion Rate — 19; 1; 0 Participants
N/A N=44 Clinical Outcomes Associated With the Use of ViviGen® for the Treatment of Lumbar Degenerative Disc Disease
Lumbar Spondylolisthesis · Degenerative Disc Disease · Degenerative Spondylolisthesis
Primary: Incidence of Successful Lumbar Fusion Measured Radiographically — 13; 11 Participants
N/A N=130 Effectiveness of Implementing Shared Decision-Making on Quality of Care Among Patients With Lumbar Degenerative Diseases.
Lumbar Degenerative Disease · Shared Decision Making · Patient Decision Aids
Primary: The Change of Patients' Control Preference — 1; 1; 16; 14 Participants
Phase 4 N=55 MiDAS II (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study
Lumbar Spinal Stenosis
Primary: Changes in Back Pain as Measured by a 10-point Visual Analog Scale (VAS). — 3.59 units on a scale — p=<0.0001