N/A N=89 SECURE®-C Cervical Artificial Disc Clinical Study/ SECURE-C Cervical Artificial Disc Postmarket Approval Study
Symptomatic Cervical Disc Disease
Primary: Individual Patient Overall Success — 127; 81; 67 participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=416 PCM Cervical Disc System
Radiculopathy · Myelopathy
Primary: Individual Patient Overall Success — 142; 98 participants
N/A N=500 Comparison of DISCOVER™ Artificial Cervical Disc and ACDF for Treatment of Cervical DDD (IDE Study)
Cervical Degenerative Disc Disease
Primary: Overall Success — 137; 110; 28; 13 participants who are successes
N/A N=40 Percutaneous Diskectomy SpineJet x Open Microdiskectomy in Treatment of Lumbar Radiculopathy
Radiculopathy · Herniated Disk
Primary: VAS for Lumbar Pain in 3 Months — 2.63; 4.53 units on a scale — p=0.05
N/A N=59 Benefit of Lumbar Bracing for Chronic Low Back Pain Due to Degenerative Disc Disease
Degenerative Disc Disease · Lumbar Spondylosis · Low Back Pain
Primary: Pain Diary — 6.71; 5 units on a scale
N/A N=20 Testing an Implementation Science Tool to Increase Cervical Cancer Screening in Mombasa, Kenya
Cervical Cancer
Primary: Cervical Cancer Screening — 198; 289 individuals screened — p=<0.001
Phase 3 N=545 Study of Safety & Effectiveness of PRESTIGE® LP Cervical Disc vs. Anterior Cervical Fusion in Cervical DDD
Cervical Degenerative Disc Disease
Primary: Rate of Overall Success — 70.4; 63.2 percentage of participants — p=0.995
N/A N=267 Investigation of the Simplify® Cervical Artificial Disc
Cervical Degenerative Disc Disease
Primary: Number of Participants With Composite Clinical Success (CCS) of Simplify Disc — 68; 132 Participants — p=<.001
N/A N=352 Investigation of the Two Level Simplify® Cervical Artificial Disc
Cervical Degenerative Disc Disorder
Primary: Composite Clinical Success (CCS) Rate of the Simplify® Disc — 153; 105 Participants — p=0.017
Phase 4 N=65 Surgery Prevention by Transforaminal Injection of Epidural Steroids for Cervical Radicular Pain
Pain, Radiating
Primary: Avoidance of Neck Surgery — 24; 20; 3; 6 Participants
N/A N=30 Trial Evaluating the Safety and Effectiveness of NUBAC™ Disc Arthroplasty
Degenerative Disc Disease
Primary: Participants With Improved Patient Function — 7; 6 participants — p=1.0
N/A N=376 Activ-L™ Artificial Disc Treatment of Degenerative Disc Disease in the Treatment of Degenerative Disc Disease
Degenerative Disc Disease
Primary: Overall Success at 24 Months Relative to Baseline — 42.2; 28.3; 61.9; 52.8 percentage of participants — p=<0.05
N/A N=248 Post-Approval Study Protocol for the Simplify Cervical Artificial Disc
Cervical Degenerative Disc Disorder
Primary: Number of Participants With Clinical Composite Success, Parent IDE Study + Post Approval Study (PAS) — 117; 40 Participants
N/A N=291 Post Approval Study Protocol for the Two Level Simplify® Cervical Artificial Disc
Cervical Degenerative Disc Disorder
Primary: Clinical Composite Success — 127; 84 Participants
Phase 4 N=33 Effectiveness of Cervical Transforaminal Epidural Steroid Injection
Cervical Radiculopathy · Cervical Spondylosis · Disk, Herniated
Primary: Percentage of Participants Reporting ≥50% Reduction in Index Numeric Rating Scale (NRS) Arm Pain Score — 19; 23; 20; 20 Participants