Phase 2 N=1,553 Studies of Elevated Parathyroid Activity
Hyperparathyroidism · Hypercalcemia · Parathyroid Neoplasm
Primary: Type of Hyperparathyroidism — 90; 276; 19; 61 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=4 Anti-3-[18F]FACBC Imaging of Parathyroid Adenomas
Parathyroid Disease
Primary: Detection Rate of Parathyroid Adenomas of Anti-3-[18F]FACBC Modality — 80 percentage of adenomas detected
N/A N=126 The Effect of Surgeon Emotional Support on Treatment Choice for Low-risk Thyroid Cancer
Thyroid Cancer · Thyroid Nodule · Benign Thyroid Nodule
Primary: Treatment Choice — 54; 51; 6; 7 Participants — p=0.720
N/A N=240 Opioid Use After Thyroid and Parathyroid Surgeries
Thyroidectomy · Parathyroidectomy · Opioid Use
Primary: New Opioid Discharge Prescriptions — 128; 28 Participants
N/A N=146 Swallowing Function Before and After Surgery for Thyroid Goiter
Hypothyroidism
Primary: Swallowing Quality of Life — 84.6; 92.3; 81.2; 87.1 units on a scale — p=0.0007
Phase 2 N=90 Central Neck Dissection in Patients With Clinical Node Negative Thyroid Cancer
Stage I Papillary Thyroid Cancer · Stage II Papillary Thyroid Cancer · Stage III Papillary Thyroid Cancer
Primary: Percentage of Participants With Transient Hypoparathyroidism, as Defined by a Day 1 Serum Parathyroid Hormone (PTH) Level of < 10 pg/ml — 24.1; 33.3 percentage of…
Phase 3 N=98 18F-Fluorocholine for the Detection of Parathyroid Adenomas
Hyperparathyroidism, Primary
Primary: Proportion of True Positives for the Overall Detection of the Abnormal Parathyroid Adenoma — 0.75 proportion of participants
Phase 4 N=36 Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease
Graves Disease · Hyperthyroidism
Primary: Blood Loss During Surgery — 61.67; 161.67 mL
N/A N=114 Assessing Benefits of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Total Thyroidectomy
Thyroid Neoplasms · Thyroid Diseases · Hypoparathyroidism
Primary: The Average Number of Parathyroid Glands Identified (Experimental Group: Glands Identified With Naked Eye + NIRAF; Control Group: Glands Identified With Naked Eye) Per…
Phase 4 N=30 Preoperative Steroids in Autoimmune Thyroid Disease
Thyroid Diseases
Primary: Thyroid Difficulty Scale Score — 9.8; 9.75 score on a scale
N/A N=160 Evaluating Impact of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Parathyroidectomy
Parathyroid Adenoma · Parathyroid Neoplasms · Parathyroid Cancer
Primary: Average Number of Parathyroid Glands Identified — 2.7; 2.6 parathyroid glands per patient — p=.6
Phase 3 N=46 Treatment of Primary Hyperparathyroidism With Denosumab and Cinacalcet.
Primary Hyperparathyroidism · Parathyroid Adenoma · Parathyroid Hyperplasia
Primary: Change in Lumbar Spine Bone Mineral Density — 0.030; 0.042; -0.016 g/cm^2 — p=< 0.00001
N/A N=12 Pre-Operative Nodal Staging of Thyroid Cancer Using USPIO MRI: Preliminary Study
Papillary Carcinoma of Thyroid Gland · Metastatic Medullary Thyroid Cancer · Follicular Thyroid Cancer Lymph Node Metastasis
Primary: Primary Efficacy Parameters of Sensitivity of High Resolution Magnetic Resonance Imaging With Lymphotrophic Superparamagnetic Nanoparticles (LSN MRI) — 85.5 percentage…
Phase 3 N=183 Superficial, Cervical Block in Thyroid Surgery, a Randomized Controlled Trial
Thyroidectomy
Primary: Post-operative Pain Measured by Visual Analogue Scale — 2.15; 2.02; 2.84; 2.72 units on a scale — p=.028
N/A N=79 Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Parathyroidectomy
Parathyroid Diseases · Parathyroid Dysfunction · Parathyroid Neoplasms
Primary: Median Number of Frozen Sections (or Parathyroid Aspirate) Sent for Analysis — 0; 0 frozen aspirate samples
N/A N=76 A Comparative Analysis of Hypocalcemia Incidence in Patients Undergoing Thyroidectomy: Ligasure vs Conventional Ligation of Vessels by Knot Tying
Hypocalcemia After Total Thyroidectomy · Hypocalcemia
Primary: Number of Participants With Hypocalcemia — 4; 3 participants
Phase 2 N=13 Energy Metabolism in Thyroidectomized Patients
Thyroid Goiter · Hypothyroidism · Thyroid Cancer
Primary: Short Term Change in Weight — 1.7; -0.76 Kilogram
N/A N=60 Comparison Between the Axillary Bilateral-breast Approach (ABBA) and Bilateral Axillo-breast Approach (BABA) for Robotic Thyroidectomy
Thyroid Papillary Carcinoma · Thyroidectomy
Primary: Change of VAS Pain Scores for the First 24 Hours — 2.13; 2.33 score
N/A N=80 Assessing Benefits of NIRAF Detection for Identifying Parathyroid Glands During Total Thyroidectomy
Postoperative Hypoparathyroidism · Thyroid Disease · Thyroid Neoplasms
Primary: Subjects With Transient Hypoparathyroidism. — 10; 14 Participants
Phase 3 N=152 Preoperative Single-dose Steroid Application for the Treatment of Nausea and Vomiting After Thyroid Surgery
Thyroidectomy · Thyroid Diseases
Primary: Incidence of Postoperative Nausea and Vomiting — 29; 57 percentage of participants — p=0.001
Phase 2 N=63 Recombinant Thyrotropin PET-CT Fusion Scanning in Thyroid Cancer
Thyroid Cancer
Primary: PET-CT Fusion Scanning Sensitivity — 49; 54 percentage of participants
N/A N=35 Diagnostic Accuracy of Shear-Wave Elastography for the Preoperative Risk Stratification of Follicular Lesions of the Thyroid
Thyroid Nodule · Follicular Neoplasm
Primary: Shear-Wave Elastography (SWE) Values in kiloPascals (kPa) — 17.50; 31.03; 23.64; 32.14 kPa
N/A N=100 The Effect of Transcutaneous Electrical Nerve Stimulation on Posterior Neck Pain After Thyroidectomy
Thyroid Cancer · Neck Pain
Primary: Numerical Rating Scale of Posterior Neck Pain 0.5 Hours After Thyroidectomy — 3.5; 0; 3.5; 0 scores on a scale
N/A N=36 Study of the Efficacy of Local Analgesia as an Adjunct to General Anesthesia in Thyroidectomy and Parathyroidectomy
Thyroid Neoplasms · Goiter, Nodular · Thyroid Nodule
Primary: Intraoperative Fentanyl Administration — 187.5; 185.7; 144.2; 156.3 mcg
N/A N=160 Assessing Benefits of NIRAF Detection for Identifying Parathyroid Glands During Total Thyroidectomy.
Postoperative Hypoparathyroidism · Thyroid Neoplasms · Thyroid Cancer
Primary: Average Number of Parathyroid Glands Identified With High Confidence Per Patient — 2.81; 2.75 parathyroid glands — p=0.6905
Phase 3 N=114 Treatment of Autonomous Hyperparathyroidism in Post Renal Transplant Recipients
Chronic Allograft Nephropathy · Chronic Kidney Disease · Chronic Renal Failure
Primary: Percentage of Participants With a Mean Corrected Total Serum Calcium Value < 10.2 mg/dL (2.55 mmol/L) During the Efficacy Assessment Phase (EAP) — 3.5; 78.9 percentage…
N/A N=160 Evaluating Impact of NIRAF Detection for Identifying Parathyroid Glands During Parathyroidectomy
Parathyroid Adenoma · Parathyroid Neoplasms · Parathyroid Hyperplasia
Primary: Average Number of Parathyroid Glands Identified With High Confidence Per Patient — 3.1; 2.7 parathyroid glands — p=0.04
N/A N=79 Efficacy and Safety of Ultrasonic Ablation to Treat Secondary Hyperparathyroidism in Chronic Kidney Disease Patients
Hyperparathyroidism · Disorders of Parathyroid Gland
Primary: Rate of Achieving the Target on Blood Intact Parathyroid Hormone Level According to Kidney Development Improvement Global Outcome (KDIGO) Guidelines. — 30.8; 57.1; 90.0…
N/A N=142 99Tc-MDP in Postmenopausal Women With Differentiated Thyroid Cancer and Osteoporosis
Differentiated Thyroid Cancer · Osteoporosis
Primary: Percent Change of Bone Mineral Density in Lumbar and Hip — 3.0; 3.2; 3.8; 5.1 percentage change
Phase 2 N=27 Intensity-Modulated Radiation Therapy (IMRT) in the Treatment of Non-Anaplastic Non-Medullary Thyroid Cancer
Thyroid Cancer
Primary: Percentage of Participants With Local-regional Progression-free Survival — 15.2 percentage of all participants