Phase 4 N=577 Benzocaine Gel Toothache Dose-Response Study
Toothache
Primary: Percentage of Participants With a Response — 70.4; 80.7; 87.3 Percentage of participants — p=<0.001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=100 Effect of Buffered Numbing Solution on Patients With Toothaches
Irreversible Pulpitis (Toothache)
Primary: Percent of Patients With Successful Anesthesia (% of Patients Able to Have Treatment Without Additional Anesthesia) — 16; 20 Participants
Phase 3 N=626 The Efficacy of a Toothpaste to Reduce Sensitivity
Dentin Hypersensitivity
Primary: Hypersensitivity Tactile(Yeaple Probe) — 19.81; 13.94 units on a scale — p=0.05
Phase 2 N=235 Efficacy Of PF-05089771 In Treating Postoperative Dental Pain
Postoperative Dental Pain
Primary: Total Pain Relief From 0 to 6 Hours (TOTPAR[6]) — 6.94; 6.21; 7.00; 14.43 units on a scale
Phase 3 N=113 Clinical Efficacy of a Toothpaste in Providing Relief From the Pain of Dentinal Hypersensitivity
Dentine Hypersensitivity
Primary: Change From Baseline in Evaporative Air Sensitivity Pain Response on a Schiff Sensitivity Scale at Day 14 — -1.20; -0.37 Score on a scale — p=<0.0001
Phase 2 N=269 A Dental Pain Study to Test the Effectiveness of a New Pain Reliever Medicine
Pain
Primary: Analgesic Efficacy From 0 to 6 Hours After the Dose Using the Time-weighted Sum of Pain Intensity Difference (SPID 0-6) — 4.37; 20.75; 8.95; 20.56 units on a scale…
N/A N=108 Effect of Root Canal Treatment (Versus no Treatment) for Patients With Tooth Infections and Toothaches
Postoperative Pain
Primary: Percent of Patients With Success as Defined by no or Mild Pain as Analyzed on a VAS Scale and no Narcotic Use — 52; 43 percentage of participants
Phase 2 N=145 SB-705498 Dental Pain Study After Tooth Extraction
Toothache
Primary: Mean of Pain Intensity Based on the Visual Analogue Scale (VAS) — 37.45; 34.95; 38.84; 17.15 Scores on a Scale
N/A N=153 A Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity
Dentin Sensitivity
Primary: Mean Tactile Sensitivity Score at Week 4 — 11.21; 23.81; 22.07 grams of force — p=<0.001
N/A N=174 Tooth Sensitivity Relief by Two Mouthrinses
Dentin Sensitivity
Primary: Mean Tactile Sensitivity Score at Week 6 — 37.91; 36.77; 30.16 grams — p=0.811
N/A N=375 Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity
Dentin Sensitivity
Primary: Percentage of Subjects With Reduction From Baseline by at Least 30% in Mean Cold Air VAS Stimulus Score at Week 4 — 44.6; 69.3 percentage of participants — p=<0.001
Phase 3 N=328 A Comparative Study of JNS013 in Participants With Post-Tooth-Extraction Pain
Pain · Postoperative Pain
Primary: Total Pain Relief Based on Numerical Rating Scale (NRS) Score — 17.7; 12.4; 13.3 Units on a scale — p=<0.0001
Phase 2 N=115 Dental Pain Study of Analgesics in Patients Undergoing Molar Removal
Dental Pain
Primary: Sum Pain Intensity Difference Scores — -2.4292; -68.0778; -68.3533; -93.3645 score on a scale
N/A N=226 A Study of the Relief of Tooth Sensitivity of an Experimental Mouthrinse Device
Dentin Sensitivity
Primary: Mean Tactile Sensitivity Score at Week 4 — 10.39; 21.83; 18.72 grams of force — p=<0.001
Phase 3 N=664 Randomized, Double-Blind, Single-Dose, Efficacy and Safety Study of Test Acetaminophen Tablet in Postoperative Dental Pain
Post-operative Dental Pain
Primary: Time to Confirmed Perceptible Pain Relief — NA; 15.7; 20.2; 23.2 minutes — p=<0.001
N/A N=79 Clinical Efficacy of a Toothpaste on Hypersensitivity Reduction
Hypersensitivity
Primary: Tooth Hypersensitity to Touch Stimuli (Tactile) — 10.83; 10.63 Units on a scale — p=0.05
Phase 2 N=122 Hydrocodone/Acetaminophen for Acute Pain Following Third Molar Tooth Extraction
Pain
Primary: Sum of Pain Intensity Difference (SPID) Using the Pain Intensity Visual Analog Scale (VAS) — 268.8; 230.9; 54.8 scores on a scale
Phase 4 N=49 Compare Anti-inflammatory Dentifrices
Gingivitis
Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05
Phase 3 N=218 Study Evaluating A Novel Ibuprofen Formulation In The Treatment Of Dental Pain
Pain
Primary: Time-weighted Sum of Pain Relief Rating With Pain Intensity Difference From 0 to 6 Hours (SPRID 0-6) — 2.8; 20.0; 17.1 units on a scale — p=<0.001
N/A N=263 A Study to Measure the Efficacy of a Toothpaste on Dentinal Hypersensitivity
Dentin Sensitivity
Primary: Thermo-evaporative (Schiff Air Blast) Stimuli — 2.188; 2.246; 1.268; 1.811 score on a scale — p=<0.001
Phase 3 N=118 The Efficacy of a Dentifrice in Providing Relief From the Pain of Dentinal Hypersensitivity
Dentine Hypersensitivity
Primary: Mean Change From Baseline in Evaporative Air Sensitivity Pain Response on a Schiff Sensitivity Scale at Week 8 — -0.9; -0.5 Score on a scale — p=<0.0001
Phase 3 N=256 Ibuprofen Extended-Release Dental Pain Study
Pain · Post-Operative Pain · Third Molar Extraction
Primary: Analgesic Efficacy, as Measured by the Sum of Pain Intensity Differences (SPID) Scale — 14.80; 0.40 Units on a scale — p=<0.0001
Phase 3 N=70 A Study to Assess Efficacy and Tolerability of Ketoprofen 40 mg Granules vs Placebo
Acute Pain
Primary: AUC0-6h of Pain Intensity Between Time 0 (Baseline Value of VAS) and 6 Hours Post-treatment in the ITT Population. — 5031; 7593 mm*min — p=0.020
Phase 3 N=540 To Evaluate the Safety and Efficacy of Acetaminophen 650 mg and 1000mg in Dental Pain After Surgery
Pain
Primary: Overall Analgesic Efficacy - Sum of Pain Intensity Difference and Pain Relief Scores Over Six Hours (SPRID6) — 529.4; 427.3; 60.0 units on a scale — p=<0.001
Phase 2 N=255 Study To Evaluate Efficacy And Safety Of An Additional Dose Of Celecoxib (YM177) In Patients With Post-Tooth Extraction Pain
Pain
Primary: Efficacy Rate (Percentage) of Patient's Impression — 64.1; 25.9 percentage of participants — p=<0.0001
Early Phase 1 N=46 Pain Management in Teeth With Reversible Pulpitis
Reversible Pulpitis · Ibuprofen
Primary: Change in Pain Intensity From Baseline (Pre-Operative) to Immediately During the Procedure (Day 0), Measured by the Visual Analogue Scale (VAS) — 5.05; 0.64 score on a…
N/A N=118 Pilot Study to Investigate the Efficacy of a Toothpaste in Providing Relief From Dentinal Hypersensitivity
Dentinal Sensitivity · Hypersensitivity
Primary: Adjusted Mean Change From Baseline in Tooth Hypersensivity to Air Stimuli Immediately Following Treatment — -0.42; -0.32 units on a scale — p=0.2294
Early Phase 1 N=114 Pre-operative Analgesics for Postoperative Pain Relief After Dental Treatment
Pain, Postoperative · Analgesia
Primary: Postoperative Pain, as Measured by Wong-Baker Facial Rating Pain Scale ,After Routine Dental Treatment — 20; 20; 7; 11 Participants
Phase 4 N=300 Post-operative Dental Pain Study Comparing Analgesic Efficacy
Post-surgical Dental Pain
Primary: Sum of Pain Relief and Pain Intensity Differences From 0 to 6 Hours (SPRID 6 Hours) — 10.60; 5.87; 3.35 Units on a scale — p=0.0004
Phase 2 N=61 Safety and Efficacy Study of XPF-001 to Treat Pain Following Wisdom Tooth Extraction
Dental Pain
Primary: Total Pain Relief at 6 Hours Post Dose (TOTPAR 6) — 2.45; 4.37 units on a scale