Clinical Trial Search

Primary: Headache Disability Inventory (HDI) — 14.3 score on a scale — p=<.0001

Primary: Change in VM-PATHI (Vestibular Migraine-Patient Assessment Tool and Handicap Inventory) Score From Baseline to Month 4 — -14.8; -5.1 score on a scale

Primary: Episodes With Vertigo Symptom Reduced From Moderate/Severe to None/Mild — 50; 73 Episodes — p=<0.33

Primary: Change in Migraine Characteristics — 43; 2; 17 Participants

Primary: Standing Vertigo Intensity — 165.10; 155.10; 136.60 mm*day — p=0.8466

Primary: Dynamic Gait Index — 18.9; 18.9; 14.2; 16.1 units on a scale — p=0.026

Primary: Visual Analog Scale - Head Movement — 1.56; 1.81 units on a scale — p=.356

Primary: Vestibulo-ocular Reflex Gain Ratio — 1.15 unitless gain ratio — p=<0.001

Primary: Subjective Symptoms Self-report of Overall Severity — 5.2; 5.2; 3.2; 2.1 score on a scale

Primary: Change in Static Subjective Visual Vertical (SVV) — 0.69; 0.58; 0.69; 0.89 degrees — p=0.97

Primary: Number of Vertigo Episodes — 5.41; 5.03; 13.78 number of episodes — p=<0.001

Primary: Peripheral Vestibular Function (Vestibulo-ocular Reflex/Semicircular Canal): Caloric Weakness — 8.8; 14.7; 12.3; 7.1 percentage of caloric weakness

Primary: Dizziness Handicap Inventory — -12.0; -13.2 score on a scale

Primary: VRT vs. ED SOC Six-Category Diagnosis Accuracy (Primary Analysis-eligible Participants, Two-arm Comparison) — 24; 18; 33; 38 Participants

Primary: Change in Visual Acuity During Head Movement From Baseline to Discharge — 0.198; .296 LogMAR

Primary: Likert Scale for Satisfaction — 9; 9 units on a scale

Primary: Scale for Vestibular Vertigo Severity Level and Clinical Response Evaluation (SVVSLCRE) — 43; 79; 104; 61 participants

Primary: Change From Baseline in the Nonmotor Symptom Severity Scale (NMSS) — -33.5; -2.0 change in scale total score — p=0.0089

Primary: Change in Balance Performance — 0.52; 0.42; 0.51; 0.48 degrees per second

Primary: Change in Ménière's Vertigo Attack Frequency Between Lamotrigine and Placebo Group — 18.88; 18.00; 13.50; 4.57 Average Total Number of Vertigo Attacks — p=0.5618

Primary: Migraine Frequency: Change From Baseline 12-week Period to Weeks 1 to 12 — -8.0; 1.0 days

Primary: Change From Baseline in Motion Sickness to Post Vestibular Stimulus — 5.1; 9 units on a scale — p=0.007

Primary: Visual Vertigo Analog Scale (VVAS) — 43.05; 36.84; 31.28; 21.41 score on a scale — p=0.027

Primary: Change From Baseline in Number of Migraine Days Per Four Weeks During the Three Months Post Treatment Investigation Duration — -1.5; -1.3 Migraine days/four weeks…

Primary: Dizziness Handicap Inventory — -17.5; -3.7; -8.4; -10.1 score on a scale — p=0.0439

Primary: Rod and Disk Test (RDT) Mean Performance — 17; 13.3; 7.8; 12.1 degrees

Primary: Perceived Usefulness — 1.99 units on a scale

Primary: Headache Pain Relief at 2 hr Post-dose by 2-point Definition — 6; 11; 13 Participants

Primary: Change in the Number of Days With Migraine (in Migraine Frequency) — 9.9; 12.4; 11.8; 6.3 days/month — p=0.001

Primary: Brain Activity Changes in Migraine Patients in Response to Treatment — -0.249; 0.679; 0.680; 1.06 Log ratio % signal change (Insula/Sp5)