Phase 2 N=9 CC-10004 For The Treatment Of Vulvodynia
Vulvodynia
Primary: Global Response Assessment — 5 participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=209 Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments
Vestibulodynia · Temporomandibular Disorder · Fibromyalgia Syndrome
Primary: Pain Score During the Tampon Test — 4.37; 3.75; 4.04; 4.36 score on a scale — p=0.3630
Phase 3 N=9 Novel Topical Therapies for the Treatment of Genital Pain
Female Genital Diseases
Primary: Reduction in Daily Genital Pain. — 2.4; 2.92; 3.42; 2.77 units on a scale — p=0.30
Phase 3 N=31 Savella in Treatment for Provoked Vestibulodynia
Vestibulodynia · Vulvodynia
Primary: Pain Rating Index — 12.3 units on a scale — p=.001
N/A N=89 Effect of Acupuncture on Patient Vulvodynia Outcomes
Vulvodynia · Vulvodynia, Generalized · Vulvar Vestibulitis
Primary: Average Pain Intensity Will be Measured With the Pain Intensity Numbers Scale (PINS). — 3.90; 3.51; 2.48; 2.22 score on a scale — p=0.702
N/A N=89 A Trial of Gabapentin in Vulvodynia: Biological Correlates of Response
Vulvodynia
Primary: Tampon Test Pain Intensity — 4.29; 3.96 units on a scale — p=0.07
N/A N=31 M-gCBT for Women With Provoked Localized Vulvodynia
Provoked Localized Vulvodynia
Primary: Tampon Test — -2.43; -1.88 units on a scale
Phase 4 N=50 Treating Postmenopausal Dyspareunia Where it Hurts
Dyspareunia
Primary: Change in Median Dyspareunia Pain Scores After 4 Weeks Using Study Drug — -1.5; -3 score on a scale — p=0.08
Phase 2 N=49 Vaginal Diazepam for the Treatment of Female Pelvic Pain
Pelvic Floor Disorders · Pelvic Pain
Primary: Visual Analog Scale (VAS) for Pain — 50; 39 score on a scale — p=0.62
Phase 4 N=10 Vulvoscopy Changes of the Vulva, Vestibule and Vagina With Daily Ospemifene in Women With Dyspareunia From VVA
Vulvovaginal Atrophy · Dyspareunia
Primary: Visible Changes to the Vulva, Vestibule and Vaginal Region on Photography — 8 points improvement on VGTA scale — p=0.05
N/A N=130 Integrated Mindfulness-based Cognitive Behaviour Therapy Versus Cognitive Behaviour Therapy for Provoked Vestibulodynia
Provoked Vestibulodynia
Primary: Change in Vulvslgesiometer Pain Rating From Baseline to One Month Post-treatment to 6 Months Post-treatment — 6.66; 6.62; 3.21; 3.60 score on a scale
N/A N=56 Dyspareunia and Central Sensitization
Endometriosis · Central Sensitisation · Dyspareunia
Primary: Deep Dyspareunia Score — 3.08 scores on a scale
Phase 3 N=550 Study to Evaluate Safety and Efficacy of WC3011 (Estradiol Vaginal Cream) in Postmenopausal Women With Dyspareunia
Vulvovaginal Atrophy
Primary: Change From Baseline in Participant's Self-Assessment of Symptom of Vulvovaginal Atrophy (VVA): Dyspareunia (Pain Associated With Sexual Activity) to Final Assessment…
Phase 2 N=17 Study of Intravaginal Tamoxifen in PostMenopausal Women With VVA
Vulvar Atrophy
Primary: Number of Subjects With Treatment Emergent Adverse Events — 3; 2; 4; 3 Participants
Phase 3 N=50 Therapy to Prevent Sexual Pain in Breast Cancer Survivors
Vulvodynia · Dyspareunia · Breast Cancer
Primary: Prevention of Entry Dyspareunia With Non-hormonal Therapy — 5.3; 1.04; NA; 0.57 Units on a scale — p=0.0149
N/A N=58 Intra-vaginal Electrical Stimulation Device Compared to Sham Device for Chronic Pelvic Pain
Pelvic Pain
Primary: Change From Baseline in Pain on the Visual Analog Scale (VAS) at Week 12 — -8.5; -7.4 units on a scale — p=0.8979
N/A N=30 Clinical Investigation to Assess the Safety and Efficacy of the Laser for the Treatment of Vulvovaginal Atrophy
Vulvovaginal Atrophy
Primary: The Main Outcome of the Study is the Efficacy of the Laser Procedure, Intended as the Amelioration of 50% of the Severity of the Vaginal Dryness at 12 Months, Compared…
Phase 3 N=826 A Clinical Study to Evaluate Ospemifene in the Treatment of Vulvar and Vaginal Atrophy in Postmenopausal Women
Atrophy · Vaginal Diseases
Primary: Mean Change From Baseline in the Most Bothersome Vulvar and Vaginal Atrophy (VVA) Symptom (MBS) of Vaginal Dryness — -1.22; -1.26; -0.84 Units on a scale
N/A N=30 Feasibility of Use of Vibrators With Vaginal Dilators for Vaginismus. (Vibrator Therapy and Dilators in Vaginismus)
Vaginismus
Primary: Is Vibration Therapy (Through the Use of Handheld External Vibrators on Clitoral and Vulval Area) Acceptable to Women as Part of Medical Management of Vaginismus and…
Phase 2 N=75 Preoperative Levator Ani Muscle Injection and Pudendal Nerve Block for Pain Control After Vaginal Reconstructive Surgery
Pelvic Organ Prolapse · Surgery · Postoperative Pain
Primary: Primary Postoperative Pain Measured by the Numerical Rating Scale (NRS) — 3.0; 4.0; 3.75 score on a scale — p=0.39
N/A N=69 Efficacy of Pain Neuroscience Education in Genito-Pelvic Pain/Penetration Disorder. A Randomized Controlled Trial.
Pain · Dysfunction Sexual
Primary: Visual Analogue Scale — 5.3; 5.8; 5.1; 3.8 score on a scale
Phase 3 N=695 Comparative Safety and Efficacy of Two Treatments in the Treatment of Vulvar and Vaginal Atrophy
Atrophy
Primary: Percentage of Subjects Identified as Responders — 36.8; 32.0; 0.8 percentage of responders
N/A N=32 Injection of Botox in the Perineal Muscles in Resistant Cases of Vaginal Spasm
Vaginismus
Primary: Success of Repeated Penetration of the Penis Through the Vaginal Introitus Into the Vagina Without or With Acceptable Pain — 28 participants
Phase 3 N=764 Estradiol Vaginal Softgel Capsules in Treating Symptoms of Vulvar and Vaginal Atrophy in Postmenopausal Women
Vulvovaginal Atrophy · Menopause · Dyspareunia
Primary: Co-Primary Efficacy Endpoint - Vaginal Superficial Cells — 17.50; 16.72; 23.20; 5.63 percentage of vaginal superficial cells — p=< 0.0001
N/A N=47 Ultrasonic Aspiration Versus CO2 Laser Ablation for the Treatment of Vulvar Intraepithelial Neoplasia
Vulvar Intraepithelial Neoplasia (VIN)
Primary: Number of Participants With Recurrence of Dysplasia — 5; 8 Participants
N/A N=72 Pudendal Nerve Block in Vaginal Surgery
Nerve Block · Pain, Postoperative · Pelvic Floor Disorders
Primary: Visual Analog Scores at 7am After Surgery — 29.2; 42.6 score on a scale
Phase 2 N=283 Study Evaluating the Efficacy and Safety of Three Formulations of Ultra-low Dose Estriol Vaginal Gel (0.005%, 0.002%, 0.0008% Estriol Vaginal Gel) for the Treatment of Vaginal Dryness in Postmenopausal Women With Vulvovaginal Atrophy
Vaginal Atrophy
Primary: Change From Baseline to Week 12 in the Severity of Vaginal Dryness — 15; 13; 13; 9 Participants — p==0.304
Phase 3 N=302 The Vaginal Health Trial
Atrophy of Vagina · Menopause · Dyspareunia (Female)
Primary: Most Bothersome Symptom (MBS) Severity — -1.2; -1.0; -0.2; -1.4 units on a scale — p=0.25
N/A N=328 Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis
Lichen Sclerosus · Lichen Planus · Lichen Simplex Chronicus
Primary: Diagnostic Accuracy of "Three Rings Vulvoscopy" by the "Vulvoscopy Index" for Detection of Vulvar Dermatosis — 72; 0; 10; 246 Participants — p=0.6108
Phase 4 N=59 Vaginal Estrogen on Postpartum Atrophy, Perineal Pain, and Sexual Function
Vaginal Atrophy
Primary: Vulvar Assessment Scale (VUAS) — 0.10; 0.20 score on a scale