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External Oblique Intercostal Plane Block reduces postoperative opioid consumption by 19.55 mg compared to standard analgesiaNew nerve block reduces opioid use after abdominal surgery

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Key Takeaway
Consider EOIPB as an effective alternative for postoperative pain control when first-line techniques like epidurals fail.

This meta-analysis evaluated the efficacy of the External Oblique Intercostal Plane Block (EOIPB) compared to standard analgesia, other regional blocks, and general anesthesia in 899 adults undergoing thoracoabdominal surgery. The primary finding was a significant reduction in opioid consumption during the first 24 hours postoperatively compared to standard analgesia (MD: -19.55; 95% CI: -28.50 to -10.60; P <0.0001). Compared specifically to other regional blocks, EOIPB also showed a significant reduction in opioid consumption (MD: -13.15; 95% CI: -24.77 to -1.52; P =0.03).

The authors noted moderate to high heterogeneity due to variations in sample sizes, anesthetic protocols, and assessment methods. Furthermore, the GRADE method categorized the quality of evidence for postoperative pain outcomes as low to very low.

Clinically, EOIPB is an effective strategy for postoperative pain control. However, it is not recommended for routine adoption for all patients; rather, it should be considered as an alternative when first-line techniques, such as epidural anesthesia, are unavailable or fail.

How this fits prior evidence

This meta-analysis addresses gaps in regional anesthesia options for thoracoabdominal surgery. It complements findings that epidural analgesia may reduce movement-related pain after laparoscopic abdominal surgery and notes that intercostal nerve cryoablation reduces inpatient opioid consumption by 102 morphine milligram equivalents. While EOIPB shows a significant reduction in opioid consumption (MD: -19.55), the evidence quality is low to very low.

Surgery on the chest and abdomen is intense, often leaving patients in significant pain. To manage this, doctors frequently rely on opioids, but finding ways to reduce these drugs while keeping patients comfortable is a major goal for surgical teams.

A review of data from 899 adults shows that a specific technique called an External Oblique Intercostal Plane Block (EOIPB) works well. When compared to standard care or other regional blocks, this method significantly lowered the amount of opioids patients used in the first 24 hours after surgery. It also showed promise in managing pain scores and reducing the need for extra rescue medications.

While these results are promising, the evidence quality is currently low to very low. Because different hospitals use different methods, it is hard to say exactly how much impact the technique has across all patients. Doctors do not recommend using this method for everyone automatically; instead, it serves as a strong alternative when first plans like epidural anesthesia are not available or do not work.

What this means for you:
The EOIPB nerve block significantly reduces opioid use in patients after thoracoabdominal surgery.

Common questions

How does this nerve block help patients after surgery?

The External Oblique Intercostal Plane Block (EOIPB) is a regional technique that helps control pain. In a study of 899 adults, this method significantly reduced the amount of opioids used in the first 24 hours after thoracoabdominal surgery compared to standard care and other regional blocks.

Is this new method better than current treatments?

The study shows that EOIPB is an effective strategy for pain control. However, it is not currently recommended as a first choice for everyone. It is best used as an alternative when primary methods, such as epidural anesthesia, are not successful or available.

Is the evidence for this treatment very strong?

The quality of evidence for pain outcomes in this study is currently rated as low to very low. This is partly due to differences in how different hospitals manage anesthesia and measure patient pain, making it hard to generalize perfectly.

Study Details

Study typeMeta analysis
Sample sizen = 899
EvidenceLevel 1
PublishedAug 2026
View Original Abstract ↓
OBJECTIVES: The primary objective of this review was to analyze the efficacy of External Oblique Intercostal Plane Block (EOIPB) in reducing the use of opioids in the postoperative period. Time and need for rescue analgesia, postoperative pain scores, and incidence of nausea and vomiting were also evaluated. METHODS: The review followed the PRISMA guidelines and was registered on PROSPERO (CRD42024622945). Randomized clinical trials that included adults undergoing thoracoabdominal surgery, comparing EOIPB with general anesthesia, multimodal anesthesia, or other regional blocks, were selected. Search was performed in May 2025 in PubMed, Embase, Scopus, and Cochrane Library databases, with no time or language restrictions. Certainty of the evidence was assessed using the GRADE system. RESULTS: Fifteen studies involving 899 patients were identified. Results indicated that EOIPB significantly reduced opioid consumption in the first 24 hours postoperatively, compared with standard analgesia (MD: -19.55; 95% CI: -28.50 to -10.60; P <0.0001, I2 =72%) and other regional blocks (MD: -13.15; 95% CI: -24.77 to -1.52; P =0.03, I2 =95%). Heterogeneity was considered moderate to high among studies, related to differences in samples, anesthetic protocols, and assessment methods. Outcomes associated with postoperative pain have a low to very low quality of evidence according to the GRADE method. DISCUSSION: The findings support the clinical potential of EOIPB as an effective strategy for postoperative pain control, but without an indication for adoption in clinical practice routine, limited to situations of failure of first-line techniques in analgesia, such as epidural anesthesia.
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