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Perioperative gabapentin fails to reduce rest pain at 24 hours after thoracic surgeryGabapentin does not reduce pain after thoracic surgery

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Key Takeaway
Interpret low-certainty evidence: gabapentin lacks meaningful benefit for thoracic surgery pain.

This meta-analysis evaluated perioperative gabapentin versus placebo in adults undergoing thoracic surgery, with a total sample of 748 patients. The primary outcome was pain at 24 hours.

For rest pain at 24 hours, gabapentin showed no significant effect (mean difference -0.13, 95% CI -1.17 to 0.91). For cough-evoked pain at 24 hours, there was a non-significant trend toward worse pain with gabapentin (mean difference 0.53, 95% CI 0.00 to 1.07). No significant effects were found for opioid consumption, pain chronification, or adverse events such as nausea, sedation, or delirium.

The authors note that the evidence was of low certainty. No serious adverse events, discontinuations, or tolerability data were reported. Funding and conflicts of interest were not reported.

In practice, these findings suggest that perioperative gabapentin does not provide meaningful benefit after thoracic surgery. Clinicians should interpret the results cautiously given the low-certainty evidence and the non-significant trend toward worse cough-evoked pain.

How this fits prior evidence

This meta-analysis contrasts with prior coverage of preoperative gabapentin reducing opioid use after arthroscopic surgery, where clinical significance was uncertain. It extends that uncertainty to thoracic surgery, finding no significant benefit on rest pain, opioid consumption, or pain chronification. The non-significant trend toward worse cough-evoked pain adds a safety consideration not highlighted in prior arthroscopic findings. Separately, prior coverage noted gabapentinoid use associated with modestly higher odds of Alzheimer's disease and related dementias, reinforcing cautious prescribing.

Managing pain after chest surgery is a major challenge for patients and doctors alike. One common approach has been using gabapentin, a medication often used to manage nerve pain, before the procedure to help keep patients comfortable during recovery.

However, a review of data from 748 adults undergoing thoracic surgery shows that gabapentin did not provide a meaningful benefit. Specifically, patients who received the drug did not report less rest pain at the 24-hour mark compared to those who received a placebo. The study also found no significant change in how much opioid medication patients used or in the development of long-term pain.

While the results are not definitive because the evidence is of low certainty, the data suggests gabapentin may not be the best tool for this specific surgery. Interestingly, there was a slight trend toward worse pain when patients coughed, though this was not statistically significant. Safety checks showed no significant difference in side effects like nausea or sedation between the two groups.

What this means for you:
Gabapentin does not appear to provide meaningful pain relief for patients undergoing thoracic surgery.

Common questions

Does gabapentin help with pain after chest surgery?

Based on data from 748 adults, gabapentin did not show a significant effect on rest pain at 24 hours after thoracic surgery. Because the evidence is of low certainty, it is best to talk to your doctor about the most effective ways to manage pain after your specific procedure.

Does gabapentin reduce the need for opioid medications?

The study found no significant effect on opioid consumption for patients undergoing thoracic surgery who were given gabapentin. This means the medication did not change how much of these stronger pain relievers patients needed during their recovery.

Are there side effects to taking gabapentin before surgery?

The study looked for side effects like nausea, sedation, or delirium. It found no significant difference in these adverse events between patients who took gabapentin and those who received a placebo.

Study Details

Study typeMeta analysis
Sample sizen = 748
EvidenceLevel 1
PublishedOct 2026
View Original Abstract ↓
AIMS: Thoracic surgery is associated with severe acute and chronic pain, high opioid use, and other adverse outcomes. Gabapentin is commonly used perioperatively, but its effectiveness remains uncertain. This systematic review and meta-analysis evaluated the efficacy and safety of perioperative gabapentin versus placebo after thoracic surgery. PATIENTS AND METHODS: Cochrane, Embase, PubMed, and Web of Science were searched through 29 August 2025 for randomized controlled trials comparing gabapentin with placebo in adults undergoing thoracic surgery. The primary outcome was pain at 24 hours. Secondary outcomes included pain at other time points, opioid consumption, chronic pain, and adverse events. Data were pooled using random-effects models. RESULTS AND CONCLUSIONS: Six trials including 748 patients were analyzed. Gabapentin had no significant effect on rest pain at 24 hours (MD -0.13; 95% CI -1.17 to 0.91). A non-significant trend toward worse cough-evoked pain at 24 hours was observed with gabapentin (MD 0.53; 95% CI 0.00 to 1.07). Gabapentin also did not significantly affect opioid consumption, pain chronification, or adverse events such as nausea, sedation, or delirium. Based on low-certainty evidence, perioperative gabapentin does not appear to provide meaningful benefit after thoracic surgery. PROTOCOL REGISTRATION: The www.crd.york.ac.uk/prospero identifier is CRD420251136259.
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