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Cardiology
Sys. Review
Argatroban switch stabilized clinical status in a patient with mechanical aortic valve and LVAD after HIT
Blood thinner switch stabilizes LVAD patient with rare clotting disorder
This case report describes the management of heparin-induced thrombocytopenia (HIT) in a patient with a mechanical aortic valve and left ven…
A patient with a mechanical heart valve and LVAD developed dangerous clots after heparin. Switching to argatroban stabilized their condition…
Frontiers
Jun 11, 2026
Neurology
RCT
Argatroban plus alteplase shows no daytime benefit but nighttime association with better stroke outcomes
Stroke drug works better at night than in the morning
This post hoc analysis of a phase 3 RCT in 692 patients with acute ischemic stroke found no significant difference in excellent functional o…
Nighttime stroke treatment with argatroban plus alteplase may improve recovery, while daytime use showed no added benefit.
May 2, 2026
Neurology
RCT
Protocol for argatroban plus clopidogrel versus aspirin plus clopidogrel in acute minor ischemic stroke
Study will compare two blood thinner combinations for minor strokes
This is a study protocol for a randomized controlled trial of 464 patients with acute minor ischemic stroke (NIHSS ≤5) within 72 hours.
A new trial will test if adding argatroban to clopidogrel leads to better recovery than aspirin plus clopidogrel for minor stroke patients.
medRxiv
Apr 4, 2026