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Neurology
Meta-analysis
Meta-analysis finds no benefit of IV thrombolysis for minor ischemic stroke
Clot-busting drugs did not improve function but raised bleeding risk for minor strokes
This systematic review and meta-analysis of RCTs involving 4,361 patients with minor ischemic stroke (NIHSS ≤5) found no significant differe…
A large review found clot-busting drugs offered no benefit for minor strokes but significantly increased the risk of dangerous brain bleedin…
Frontiers
Apr 29, 2026
Neurology
RCT
Tenecteplase shows worse functional outcomes in older patients with minor ischemic stroke compared to standard care.
The Clot-Busting Drug That Backfires in Patients Over 80
This post hoc analysis of a randomized controlled trial evaluated tenecteplase versus nonthrombolytic standard of care in 884 patients with …
In patients over 80 with minor stroke, a clot-busting drug improved short-term recovery but worsened outcomes at 90 days compared to standar…
Apr 16, 2026