Review of ruxolitinib for systemic juvenile arthritis with macrophage activation syndrome
Two children with severe arthritis found relief using a new drug approach
This narrative review synthesizes a retrospective case series and literature search on ruxolitinib for systemic juvenile idiopathic arthriti…
Two children with severe arthritis complications found relief using a new drug approach, offering hope for those who struggle with standard …
CHIP mutations increase cardiovascular risk and mortality in older adults independent of traditional factors
Your Aging Blood Cells May Be Quietly Attacking Your Heart
This review synthesizes evidence regarding clonal hematopoiesis of indeterminate potential (CHIP) in individuals older than 70 years.
Aging blood cell mutations called CHIP quietly raise heart attack risk by fueling inflammation, affecting over 10% of adults over 70.
Canakinumab shows efficacy in Japanese AOSD patients in Phase 3 open-label study
Could a monthly injection help control the painful flares of Adult-Onset Still's Disease?
A Phase 3, open-label, single-arm study evaluated canakinumab in 14 Japanese patients with Adult-Onset Still's Disease.
A monthly injection helped Japanese patients with Adult-Onset Still's Disease achieve meaningful symptom relief, supporting approval for thi…