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Rheumatology
RCT
Certolizumab pegol dose escalation from 200 mg to 400 mg results in 2-fold increase in plasma concentration
Trial shows dose changes impact drug levels in rheumatoid arthritis
This post hoc analysis of a Phase III trial and open-label extension evaluated certolizumab pegol pharmacokinetics in 982 patients with acti…
New analysis shows that changing the dosage of certolizumab pegol directly affects how much medicine stays in a patient's bloodstream.
Aug 4, 2026
Rheumatology
RCT
Biological DMARDs show marginal patient-reported outcome benefits over conventional therapy in early rheumatoid arthritis
Early rheumatoid arthritis patients report similar symptom relief with different treatment approaches
This open-label randomized trial in 795 newly diagnosed, DMARD-naïve RA patients compared three biological DMARDs plus methotrexate against …
In early rheumatoid arthritis, patients reported similar pain relief and quality-of-life improvements whether they started with conventional…
Apr 9, 2026