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Home › Medications › chlorhexidine

chlorhexidine

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of chlorhexidine

27 trials tracked of chlorhexidine: 10 in phase 3 or 4 and 1 with published results. The most-cited published study has 10 citations.

27Trials tracked
10Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 3 Phase 3 7 Phase 2 4 Phase 1 2 Other / NA 11
  1. Phase 3 Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction Completed · 10 cited
  2. Phase 4 Evaluation of a Staphylococcus Eradication Protocol for Patients Who Present to the ED With Cutaneous Abscess Completed
  3. Phase 4 BPO vs Hibiclens Soap for Surgical Preparation Completed
  4. Phase 4 Staph Household Intervention for Eradication (SHINE) Completed
  5. Phase 3 Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Volunteers Completed
  6. Phase 3 Preoperative CHG Cloth on Healthy Subjects Completed
Show 21 more trials
  1. Phase 3 Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Subjects Completed
  2. Phase 3 Evaluate Clinical Research From Commerical Oral Care Products Completed
  3. Phase 3 Study to Determine the Anti-plaque Efficacy of Commerical Toothpastes and an Oral Rinse Completed
  4. Phase 3 Clinical Performance of a Chlorhexidine Antimicrobial Dressing Completed
  5. Phase 2 Decolonization of the Oropharynx, an Important and Neglected Reservoir of S. Aureus Colonization Completed
  6. Phase 2 Preventing Diabetic Foot Ulcers Through Cleaner Feet Completed
  7. Phase 2 The Effect of Chlorhexidine on the Oral and Lung Microbiota in Chronic Obstructive Pulmonary Disease Completed
  8. Phase 2 Evaluating Safety and Effectiveness of Octenidine Dihydrochloride Completed
  9. Phase 1 Pilot Study: Safety of Chlorhexidine (CHG) Baths in Patients Less Than 2 Months of Age Completed
  10. Phase 1 Single Dose CHG Pharmacokinetic Study Completed
  11. N/A Comparison of Surgical Skin Preps During Cesarean Deliveries Completed
  12. N/A Methicillin-resistant Staphylococcus Aureus (MRSA) Skin and Soft Tissue Infection (SSTI) Prevention in Military Trainees Completed
  13. N/A Safety of Skin Cleansing With Chlorhexidine in Preterm Low Birth Weight Infants Completed
  14. N/A Cost-Effectiveness Study Comparing Chlorhexidine Bathing With Active Surveillance Cultures to Prevent Methicillin-resistant Staphylococcus Aureus & Other Hospital Infections Completed
  15. N/A Trial of 2% Chlorhexidine Bathing on Nosocomial Infections in the Surgical Intensive Care Unit Completed
  16. N/A Nitrous Oxide for Pain Management of Intrauterine Device (IUD) Insertion Completed
  17. N/A A Cluster-randomized Cross-over Trial Evaluating the Comparative Effectiveness of Three Skin Antiseptic Interventions Completed
  18. N/A Checklist to Prevent MRSA Surgical Site Infections Completed
  19. N/A Chlorhexidine Drying Time Completed
  20. N/A Chlorhexidine Gluconate Oral Care for Adults Experiencing Trauma Completed
  21. N/A Trial to Assess the Effects of an Antimicrobial Mouthwash on the Esophageal Microbiome Completed

Showing the 27 most-cited and recently-updated of 27 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Meta-Analysis Shows No SSI Difference Between Chlorhexidine and Povidone Iodine for Vaginal Antisepsis
OB/GYN & Women's Health Meta-analysis
Meta-Analysis Shows No SSI Difference Between Chlorhexidine and Povidone Iodine for Vaginal Antisepsis Vaginal cleaning with chlorhexidine does not prevent infections better than iodine in major gynecologic surgeries
This systematic review and meta-analysis evaluated vaginal antisepsis in 9538 patients undergoing major gynecologic operations. The analysis…
A large review of nearly 10,000 patients found that using chlorhexidine for vaginal cleaning did not lower infection risk compared to iodine…
medRxiv May 28, 2026
Meta-analysis of 16 trials shows no added benefit of subgingival chemical irrigation for periodontitis
Physical Medicine & Rehab Meta-analysis
Meta-analysis of 16 trials shows no added benefit of subgingival chemical irrigation for periodontitis Deep cleaning your gums? That extra rinse may not help at all
This systematic review and meta-analysis evaluated 16 randomized clinical trials comparing subgingival irrigation with chemical agents versu…
If you have gum disease and your dentist suggests a special rinse during a deep cleaning, new research says it probably won't make a differe…
May 13, 2026
Chlorhexidine May Reduce Neonatal Mortality and Infection in LMICs
Pediatrics Meta-analysis
Chlorhexidine May Reduce Neonatal Mortality and Infection in LMICs Can antiseptics on the umbilical cord save newborns from infection and death?
Meta-analysis shows 4.0% chlorhexidine reduces neonatal mortality (RR 0.86) and omphalitis (RR 0.71) in LMICs, but delays cord separation by…
Applying chlorhexidine to the umbilical cord may lower the risk of infection and death in newborns in low-income countries.
Mar 28, 2026