Azithromycin reduces maternal infection in laboring women in low- and middle-income countries
Antibiotic reduces maternal infection risk in labor
This secondary analysis of an RCT found that azithromycin reduced maternal infection and sepsis in women in labor, with a larger reduction a…
A single dose of azithromycin during labor lowered maternal infections in a large trial across seven countries.
Systematic Review and Meta-Analysis Finds IL-27 Superior to CRP for Neonatal Sepsis Diagnosis
A New Blood Test May Spot Newborn Sepsis Faster Than Current Methods
This systematic review and meta-analysis of 495 neonates compared IL-27 to C-reactive protein for diagnosing neonatal sepsis. IL-27 showed h…
A simple blood marker called IL-27 catches newborn sepsis more accurately than the standard test, potentially saving lives by speeding up di…
Weekend births linked to longer antibiotic exposure in very low birth weight infants with suspected sepsis
Weekend births delay antibiotic stops for fragile newborns
This retrospective cohort study examined antibiotic exposure times in very low birth weight infants with suspected early-onset sepsis and ne…
New research shows babies born on weekends stay on antibiotics longer than those born during the work week.
Prophylactic azithromycin during labor increases S. aureus resistance in mothers and infants
Azithromycin in Labor Raises Short-Term Resistance Risk
This RCT sub-study of 911 women and 915 infants found that prophylactic oral azithromycin during labor increased azithromycin resistance in …
This could change how we balance infection protection and antibiotic safety in childbirth.
7-Day Antibiotic Regimen Non-Inferior to 14-Day for Uncomplicated Neonatal Sepsis in RCT
Can shorter antibiotics cure newborn sepsis just as well as two weeks of treatment?
This randomized control assessor-blinded trial evaluated 140 neonates weighing ≥ 1000 g with culture-positive sepsis in a tertiary Neonatal …
A 7-day antibiotic course for newborn sepsis worked as well as 14 days, with babies leaving the hospital sooner and needing less breathing s…
AMR strategies in LMIC newborns reduce antibiotic use and mortality in meta-analysis
Strategies to reduce antibiotic resistance may lower infection risks in newborns in low-income countries
A systematic review and meta-analysis of 31 facility-based studies in LMICs found that strategies to reduce antimicrobial resistance, includ…
Strategies to curb antibiotic resistance in newborns in low-income countries lower infection risks and reduce overall mortality.
Maternal preeclampsia modestly increases neonatal sepsis risk in infants up to 28 days of age
A Mother’s High Blood Pressure May Raise Her Newborn’s Infection Risk
This systematic review and meta-analysis evaluated 1,513,008 neonates to assess the association between maternal preeclampsia and neonatal s…
Babies born to mothers with preeclampsia face a 27% higher risk of serious infection in the first month of life, prompting doctors to watch …
Case-control study identifies K. pneumoniae proteins associated with lack of neonatal sepsis
Study identifies potential vaccine targets for deadly newborn infection in Africa
A case-control study of 100 mother-baby dyads in sub-Saharan Africa analyzed antibody responses to 161 K.
Specific bacterial proteins might protect newborns from deadly sepsis via maternal antibodies, paving the way for a vaccine in sub-Saharan A…
Chlorhexidine May Reduce Neonatal Mortality and Infection in LMICs
Can antiseptics on the umbilical cord save newborns from infection and death?
Meta-analysis shows 4.0% chlorhexidine reduces neonatal mortality (RR 0.86) and omphalitis (RR 0.71) in LMICs, but delays cord separation by…
Applying chlorhexidine to the umbilical cord may lower the risk of infection and death in newborns in low-income countries.
Research across Systemic Inflammatory Response Syndrome
Related studies from across the Systemic Inflammatory Response Syndrome family.
Cystatin C shows good diagnostic performance with an AUC of 0.88 for early detection of SA-AKI
Cystatin C shows promise for early detection of kidney injury
This meta-analysis of 17 studies evaluates the diagnostic performance of Cystatin C for detecting acute kidney injury in patients with sepsi…
A new look at 17 studies suggests that Cystatin C could help doctors identify kidney damage in sepsis patients much earlier than current met…
Sepsis Mortality Prediction Models Show Moderate Performance
Prediction models show moderate success in forecasting sepsis deaths
A meta-analysis of 84 studies finds that externally validated models for sepsis mortality achieve a pooled AUC of 0.794, but most studies ha…
New data from millions of records helps identify which factors most accurately predict if a patient with sepsis will survive.
Prediction models show moderate discrimination for ARDS occurrence and mortality in sepsis patients
Machine Learning Models Show Mixed Results for Predicting Sepsis Lung Injury
This systematic review and meta-analysis evaluated prediction models for ARDS occurrence and short-term mortality in patients with sepsis-as…
New analysis shows that while machine learning can predict lung injury in sepsis patients, these models do not consistently outperform stand…
Gut microbiota dysbiosis and microbial metabolites impair renal function in sepsis-associated acute kidney injury
Sepsis may damage kidneys by letting gut bacteria toxins leak into the blood
This narrative review examines the role of gut microbiota dysbiosis in sepsis-associated acute kidney injury and acute kidney injury. The au…
A review suggests that sepsis changes gut bacteria, causing harmful toxins to leak and hurt kidneys in humans and animals.
Modulation of neutrophil function and death in critically ill patients with sepsis is discussed in this narrative review
Review discusses neutrophil modulation in sepsis for critically ill patients
This narrative review discusses modulation of neutrophil function and death in critically ill patients with sepsis. The authors synthesize c…
This narrative review explores how changing neutrophil function might affect sepsis outcomes in critically ill patients, though no specific …
Source control and antibiotic stewardship remain cornerstones of sepsis management
Review prioritizes antibiotic stewardship over live probiotics for sepsis
This narrative review synthesizes current evidence on sepsis management, emphasizing source control and antibiotic stewardship as key pillar…
A narrative review suggests avoiding live probiotics in high-risk sepsis patients while prioritizing antibiotic stewardship and source contr…
Antibiotic stewardship bundle aims to cut antibiotic use in Chinese NICUs
A new plan aims to cut unnecessary antibiotics for sick newborns in China
This protocol describes a multicenter, before-and-after, interrupted time series quality improvement study testing a bundled antimicrobial s…
This ongoing project in China seeks to reduce antibiotic use for newborns with sepsis while keeping them safe during treatment.
Interleukin-7 therapy improves lymphocyte counts in sepsis and COVID-19 patients
Recombinant human interleukin-7 boosts white blood cells but does not save lives in sepsis or COVID-19
A meta-analysis shows recombinant IL-7 boosts lymphocytes in sepsis and COVID-19, but only reduces secondary infections in COVID-19.
A new analysis shows this drug raises low white blood cell counts in sepsis and COVID-19 but does not lower death risk or improve survival.
Antioxidant nanomedicine in sepsis: a narrative review with no reported outcomes or safety data
Antioxidant nanomedicine review explores sepsis treatment options
This narrative review discusses antioxidant nanomedicine for sepsis. The authors note that key details such as population, sample size, outc…
A review looks at antioxidant nanomedicine for sepsis, a serious infection that kills many people. More research is needed to see if this ap…
Systematic review and meta-analysis of sepsis screening tools in low- and middle-income countries
Sepsis screening tools show mixed accuracy in low-income country adult patient groups
This systematic review and meta-analysis evaluated sepsis screening tools in adult populations in low- and middle-income countries. It found…
A review of thirty thousand patients found that common sepsis checklists work differently in low-income areas. Some tools miss cases while o…
Narrative review on PAD4-mediated citrullination and PAD4-directed therapies for multiple inflammatory conditions
A new enzyme target could treat many serious diseases at once
This narrative review synthesizes evidence on PAD4-mediated citrullination and PAD4-directed therapies for conditions including rheumatoid a…
A single enzyme called PAD4 helps cause many different diseases, and new medicines targeting it might finally help people with multiple cond…
Secondary analysis of 342 sepsis patients reveals limited diagnostic utility for serum biomarkers in invasive candidiasis diagnosis
Doctors tested blood markers to find infection signs in sick patients quickly
Analysis of 342 sepsis patients across German ICUs shows serum antigens rise in infection, but antibodies do not. Single biomarkers offer mo…
A study of 342 sick patients found that one specific blood test works best for spotting dangerous infections. Combining multiple tests did n…
Questions about Neonatal Sepsis
Does reducing antibiotic use help lower neonatal sepsis mortality rates?
Reducing unnecessary antibiotic use through antimicrobial stewardship strategies in newborns can lower both antibiotic exposure and mortality rates, especially in low-resource settings.
Full answer →Does maternal preeclampsia increase the risk of neonatal sepsis in my baby?
Yes, maternal preeclampsia is linked to a modestly higher risk of neonatal sepsis in the first 28 days of life, based on a large meta-analysis.
Full answer →