Base excess shows 85.8% sensitivity and 82.9% specificity for neonatal sepsis diagnosis in meta-analysis
Base Excess Levels May Help Identify Neonatal Sepsis Risk
This meta-analysis evaluated base excess (BE) for diagnosing and prognosing neonatal sepsis. Pooled sensitivity at ≤-5 mEq/L was 85.8% and s…
A new analysis suggests that measuring base excess levels could help doctors identify and predict risks in infants with neonatal sepsis.
Azithromycin reduces maternal infection in laboring women in low- and middle-income countries
Antibiotic reduces maternal infection risk in labor
This secondary analysis of an RCT found that azithromycin reduced maternal infection and sepsis in women in labor, with a larger reduction a…
A single dose of azithromycin during labor lowered maternal infections in a large trial across seven countries.
Systematic Review and Meta-Analysis Finds IL-27 Superior to CRP for Neonatal Sepsis Diagnosis
A New Blood Test May Spot Newborn Sepsis Faster Than Current Methods
This systematic review and meta-analysis of 495 neonates compared IL-27 to C-reactive protein for diagnosing neonatal sepsis. IL-27 showed h…
A simple blood marker called IL-27 catches newborn sepsis more accurately than the standard test, potentially saving lives by speeding up di…
Weekend births linked to longer antibiotic exposure in very low birth weight infants with suspected sepsis
Weekend births delay antibiotic stops for fragile newborns
This retrospective cohort study examined antibiotic exposure times in very low birth weight infants with suspected early-onset sepsis and ne…
New research shows babies born on weekends stay on antibiotics longer than those born during the work week.
Prophylactic azithromycin during labor increases S. aureus resistance in mothers and infants
Azithromycin in Labor Raises Short-Term Resistance Risk
This RCT sub-study of 911 women and 915 infants found that prophylactic oral azithromycin during labor increased azithromycin resistance in …
This could change how we balance infection protection and antibiotic safety in childbirth.
7-Day Antibiotic Regimen Non-Inferior to 14-Day for Uncomplicated Neonatal Sepsis in RCT
Can shorter antibiotics cure newborn sepsis just as well as two weeks of treatment?
This randomized control assessor-blinded trial evaluated 140 neonates weighing ≥ 1000 g with culture-positive sepsis in a tertiary Neonatal …
A 7-day antibiotic course for newborn sepsis worked as well as 14 days, with babies leaving the hospital sooner and needing less breathing s…
AMR strategies in LMIC newborns reduce antibiotic use and mortality in meta-analysis
Strategies to reduce antibiotic resistance may lower infection risks in newborns in low-income countries
A systematic review and meta-analysis of 31 facility-based studies in LMICs found that strategies to reduce antimicrobial resistance, includ…
Strategies to curb antibiotic resistance in newborns in low-income countries lower infection risks and reduce overall mortality.
Maternal preeclampsia modestly increases neonatal sepsis risk in infants up to 28 days of age
A Mother’s High Blood Pressure May Raise Her Newborn’s Infection Risk
This systematic review and meta-analysis evaluated 1,513,008 neonates to assess the association between maternal preeclampsia and neonatal s…
Babies born to mothers with preeclampsia face a 27% higher risk of serious infection in the first month of life, prompting doctors to watch …
Case-control study identifies K. pneumoniae proteins associated with lack of neonatal sepsis
Study identifies potential vaccine targets for deadly newborn infection in Africa
A case-control study of 100 mother-baby dyads in sub-Saharan Africa analyzed antibody responses to 161 K.
Specific bacterial proteins might protect newborns from deadly sepsis via maternal antibodies, paving the way for a vaccine in sub-Saharan A…
Chlorhexidine May Reduce Neonatal Mortality and Infection in LMICs
Can antiseptics on the umbilical cord save newborns from infection and death?
Meta-analysis shows 4.0% chlorhexidine reduces neonatal mortality (RR 0.86) and omphalitis (RR 0.71) in LMICs, but delays cord separation by…
Applying chlorhexidine to the umbilical cord may lower the risk of infection and death in newborns in low-income countries.
Research across Systemic Inflammatory Response Syndrome
Related studies from across the Systemic Inflammatory Response Syndrome family.
Gut-kidney axis drives sepsis-associated AKI, review argues for microecological and neuromodulatory therapies
New Approaches Target Gut Health to Treat Sepsis Kidney Damage
This systematic review examines the gut-kidney axis as a mechanistic driver of sepsis-associated acute kidney injury and evaluates microecol…
New research explores how targeting the gut-kidney axis could help treat and prevent kidney damage in patients with sepsis.
Admission hypoalbuminemia is associated with increased mortality and acute kidney injury in burn patients
Low Serum Albumin Linked to Higher Mortality in Burn Patients
This meta-analysis of 9 studies indicates that hypoalbuminemia on admission is significantly associated with increased mortality (OR 9.51) a…
Low serum albumin levels at the time of admission are linked to a higher risk of death and kidney damage in patients with burn injuries.
Intravenous vitamin C associated with reduced mortality in patients with sepsis and septic shock
Vitamin C May Reduce Mortality in Patients with Sepsis
This meta-analysis evaluated the impact of intravenous vitamin C on outcomes for patients with sepsis or septic shock. The authors observed …
A review of data suggests intravenous vitamin C may lower death rates for patients with sepsis, though the evidence quality remains low.
Early Feeding in VLBW Infants Safe, Cuts Sepsis Risk
Early feeding may reduce sepsis in very low birth weight infants
Meta-analysis finds early enteral feeding in VLBW infants reduces sepsis and time to full feeds without increasing NEC or mortality.
Early feeding within 72 hours may help very low birth weight infants reach full nutrition faster and reduce the risk of sepsis.
Higher PNI scores are associated with lower short-term mortality in patients with sepsis
Nutritional scores help identify patients at risk from sepsis
This meta-analysis of 34,810 patients evaluated various nutritional assessment tools for sepsis mortality. Higher PNI scores were associated…
New data shows that specific nutritional assessment tools can help doctors identify which sepsis patients are at the highest risk for death.
Butyrylcholinesterase activity predicts in-hospital mortality in critically ill adults with sepsis
Butyrylcholinesterase levels help predict survival in patients with sepsis
This individual participant data meta-analysis of 482 critically ill adults with sepsis found that higher Day-1 butyrylcholinesterase (BChE)…
Doctors may soon use butyrylcholinesterase levels to better predict which critically ill patients with sepsis are at higher risk of dying.
Elevated syndecan-1 levels correlate with severity and poor outcomes in patients with sepsis
Higher syndecan-1 levels linked to severe sepsis and poor outcomes
This meta-analysis of 4985 patients, including 3902 with sepsis, found significantly higher circulating syndecan-1 levels in sepsis patients…
A new analysis shows that higher levels of a specific protein can help doctors identify patients with the most severe forms of sepsis.
Balanced crystalloid solutions reduce mortality and acute kidney injury in adult patients with sepsis
Balanced crystalloid solutions show lower death rates in sepsis patients
This meta-analysis of 7 trials involving 8,173 adults with sepsis found that balanced crystalloids significantly reduced mortality (RR 0.92)…
A large review of over 8,000 patients suggests balanced crystalloid fluids may reduce mortality and kidney damage for those with sepsis.
Mitochondrial dysfunction shapes immune cell function across sepsis phases, review finds
Mitochondrial Function Shapes Immune Response During Sepsis
This mini-review synthesizes evidence on mitochondrial immunometabolism in sepsis, describing how bioenergetic dysfunction and quality-contr…
New research highlights how mitochondrial health impacts immune cell function and organ damage during different stages of sepsis.
Five pathways drive sepsis-induced cardiomyopathy; imaging and biomarker panels improve early diagnosis
New Strategies for Managing Sepsis Induced Heart Damage
This systematic review synthesizes current knowledge on sepsis-induced cardiomyopathy (SIC), identifying five major pathological pathways th…
Newer imaging tools and biomarker panels help doctors identify heart damage from sepsis earlier to move toward more precise, targeted treatm…
Low-dose corticosteroids reduce 90-day mortality in adults with severe community-acquired pneumonia
Low dose steroids may lower death rates in severe lung infections
This meta-analysis of 4,622 patients found that low-dose corticosteroids (≤400 mg hydrocortisone-equivalent daily) significantly reduced sho…
A review of clinical trials suggests that low-dose corticosteroids can reduce 90-day mortality for adults with severe lung infections like p…
Neonatal neutrophil function varies by assay; chemotaxis and NETs often constrained
Understanding How Immune Cells Protect Newborns from Serious Infections
This mini review synthesizes human neonatal studies on neutrophil function. Chemotaxis and extracellular-trap formation are often developmen…
New research looks at how white blood cells in babies fight infections while trying to avoid causing tissue damage.
Questions about Neonatal Sepsis
Does reducing antibiotic use help lower neonatal sepsis mortality rates?
Reducing unnecessary antibiotic use through antimicrobial stewardship strategies in newborns can lower both antibiotic exposure and mortality rates, especially in low-resource settings.
Full answer →Does maternal preeclampsia increase the risk of neonatal sepsis in my baby?
Yes, maternal preeclampsia is linked to a modestly higher risk of neonatal sepsis in the first 28 days of life, based on a large meta-analysis.
Full answer →