Base excess shows 85.8% sensitivity and 82.9% specificity for neonatal sepsis diagnosis in meta-analysis
Base Excess Levels May Help Identify Neonatal Sepsis Risk
This meta-analysis evaluated base excess (BE) for diagnosing and prognosing neonatal sepsis. Pooled sensitivity at ≤-5 mEq/L was 85.8% and s…
A new analysis suggests that measuring base excess levels could help doctors identify and predict risks in infants with neonatal sepsis.
Azithromycin reduces maternal infection in laboring women in low- and middle-income countries
Antibiotic reduces maternal infection risk in labor
This secondary analysis of an RCT found that azithromycin reduced maternal infection and sepsis in women in labor, with a larger reduction a…
A single dose of azithromycin during labor lowered maternal infections in a large trial across seven countries.
Systematic Review and Meta-Analysis Finds IL-27 Superior to CRP for Neonatal Sepsis Diagnosis
A New Blood Test May Spot Newborn Sepsis Faster Than Current Methods
This systematic review and meta-analysis of 495 neonates compared IL-27 to C-reactive protein for diagnosing neonatal sepsis. IL-27 showed h…
A simple blood marker called IL-27 catches newborn sepsis more accurately than the standard test, potentially saving lives by speeding up di…
Weekend births linked to longer antibiotic exposure in very low birth weight infants with suspected sepsis
Weekend births delay antibiotic stops for fragile newborns
This retrospective cohort study examined antibiotic exposure times in very low birth weight infants with suspected early-onset sepsis and ne…
New research shows babies born on weekends stay on antibiotics longer than those born during the work week.
Prophylactic azithromycin during labor increases S. aureus resistance in mothers and infants
Azithromycin in Labor Raises Short-Term Resistance Risk
This RCT sub-study of 911 women and 915 infants found that prophylactic oral azithromycin during labor increased azithromycin resistance in …
This could change how we balance infection protection and antibiotic safety in childbirth.
7-Day Antibiotic Regimen Non-Inferior to 14-Day for Uncomplicated Neonatal Sepsis in RCT
Can shorter antibiotics cure newborn sepsis just as well as two weeks of treatment?
This randomized control assessor-blinded trial evaluated 140 neonates weighing ≥ 1000 g with culture-positive sepsis in a tertiary Neonatal …
A 7-day antibiotic course for newborn sepsis worked as well as 14 days, with babies leaving the hospital sooner and needing less breathing s…
AMR strategies in LMIC newborns reduce antibiotic use and mortality in meta-analysis
Strategies to reduce antibiotic resistance may lower infection risks in newborns in low-income countries
A systematic review and meta-analysis of 31 facility-based studies in LMICs found that strategies to reduce antimicrobial resistance, includ…
Strategies to curb antibiotic resistance in newborns in low-income countries lower infection risks and reduce overall mortality.
Maternal preeclampsia modestly increases neonatal sepsis risk in infants up to 28 days of age
A Mother’s High Blood Pressure May Raise Her Newborn’s Infection Risk
This systematic review and meta-analysis evaluated 1,513,008 neonates to assess the association between maternal preeclampsia and neonatal s…
Babies born to mothers with preeclampsia face a 27% higher risk of serious infection in the first month of life, prompting doctors to watch …
Case-control study identifies K. pneumoniae proteins associated with lack of neonatal sepsis
Study identifies potential vaccine targets for deadly newborn infection in Africa
A case-control study of 100 mother-baby dyads in sub-Saharan Africa analyzed antibody responses to 161 K.
Specific bacterial proteins might protect newborns from deadly sepsis via maternal antibodies, paving the way for a vaccine in sub-Saharan A…
Chlorhexidine May Reduce Neonatal Mortality and Infection in LMICs
Can antiseptics on the umbilical cord save newborns from infection and death?
Meta-analysis shows 4.0% chlorhexidine reduces neonatal mortality (RR 0.86) and omphalitis (RR 0.71) in LMICs, but delays cord separation by…
Applying chlorhexidine to the umbilical cord may lower the risk of infection and death in newborns in low-income countries.
Research across Systemic Inflammatory Response Syndrome
Related studies from across the Systemic Inflammatory Response Syndrome family.
Bleeding, sepsis, and liver impairment each independently raise thrombocytopenia risk in ICU patients
Critical illness factors linked to lower platelet counts in patients
This meta-analysis of 27,147 critically ill patients found that bleeding (OR 3.49), sepsis (OR 2.32), and impaired liver function (OR 1.55) …
New data shows that bleeding, sepsis, and liver issues significantly increase the risk of low platelets in critically ill patients.
Age, male sex, low BMI, and comorbidities like diabetes are significant risk factors for sepsis incidence
Age, diabetes, and COPD raise sepsis risk, meta-analysis finds
This meta-analysis of 21 studies identifies several significant risk factors associated with increased sepsis incidence, including age over …
A new analysis of 21 studies pinpoints key risk factors for sepsis, including age, diabetes, and COPD.
Early postnatal antibiotic exposure increases BPD risk in very preterm infants across 11 studies
Early Antibiotic Exposure Linked to Risks for Very Preterm Infants
This meta-analysis of 11 studies indicates that early postnatal antibiotic exposure is associated with an increased risk of bronchopulmonary…
Early antibiotic use in very preterm infants is linked to higher risks of lung issues, intestinal damage, and mortality.
Toll-like receptor signaling governs inflammatory phenotypes and progression in infectious myocarditis
Toll-like receptors shape severity of infectious myocarditis
This systematic review examines the role of toll-like receptors (TLRs) in infectious myocarditis associated with COVID-19, influenza, and se…
A systematic review finds that pathogen-specific TLR signaling determines inflammation and outcomes in infectious myocarditis, with COVID-19…
HMGB1 and LPS interactions provide potential therapeutic targets for inflammation and coagulation in sepsis
New research identifies how specific proteins drive sepsis inflammation
This narrative review explores the mechanistic roles of Lipopolysaccharide (LPS) and High Mobility Group Box 1 (HMGB1) in sepsis. The author…
Scientists have identified a specific interaction between two molecules that triggers severe inflammation and organ failure during sepsis.
Sepsis is an inflammation-driven immune reprogramming disorder characterized by time-resolved trajectories and biologically defined subtypes
New research reframes sepsis as an immune reprogramming disorder
This narrative review explores the pathophysiology of sepsis as a dynamic immune reprogramming disorder involving hyperinflammation and low-…
Sepsis is more than just a severe infection; it is now being understood as a complex failure of the body's immune system.
Adrenergic receptor signaling modulates pulmonary innate immunity and barrier integrity in acute lung injury
Understanding How Nerve Signals Influence Lung Health During Severe Respiratory Infections
This systematic review synthesizes the role of adrenergic receptors (ARs) as a molecular interface between the sympathetic nervous system an…
New research explores how specific nerve signals help control inflammation and protect the lungs during severe lung infections.
Hyperoxygenation target (PaO2: 100-150 mmHg) reduces 28-day mortality in patients with sepsis
Higher oxygen targets may lower death rates for sepsis patients
This randomized controlled trial of 270 patients with sepsis found that a hyperoxygenation target of PaO2: 100-150 mmHg significantly reduce…
A new trial shows that giving higher levels of oxygen to patients with sepsis can significantly reduce deaths within the first 28 days.
Lactobacillus rhamnosus GG does not significantly impact composite outcomes in VLBW infants
Trial shows probiotic LGG does not improve outcomes for infants
This randomized controlled trial of 236 enterally-fed very low birth weight infants found no significant difference in the primary composite…
A trial of 236 very low birth weight infants found that a specific probiotic did not reduce risks like sepsis or intestinal issues.
Novel biomarkers and machine learning algorithms facilitate earlier identification and diagnosis of sepsis
New Diagnostic Tools May Help Identify Sepsis More Quickly
This narrative review explores the evolution of sepsis diagnostic strategies from traditional clinical scoring systems to advanced markers l…
Newer biomarkers and machine learning tools are evolving beyond traditional scoring systems to help doctors identify sepsis earlier in patie…
Bovine milk fortifiers non-inferior to human milk fortifiers for NEC and sepsis in pre-term newborns
Bovine Milk Fortifiers Show Similar Results to Human Milk
This meta-analysis of 3371 publications found that bovine milk-based fortifiers are non-inferior to human milk-based fortifiers for necrotiz…
A large review of research suggests that bovine milk based fortifiers are as safe and effective as human milk for newborns with specific con…
Elevated HMGB1 levels correlate with sepsis diagnosis and increased mortality risk in adult patients
High HMGB1 levels linked to sepsis and higher mortality
This meta-analysis of 3,110 patients found that serum or plasma HMGB1 levels are significantly higher in sepsis patients compared to healthy…
Higher levels of the protein HMGB1 in the blood are linked to more severe cases of sepsis and an increased risk of death for patients.
Questions about Neonatal Sepsis
Does reducing antibiotic use help lower neonatal sepsis mortality rates?
Reducing unnecessary antibiotic use through antimicrobial stewardship strategies in newborns can lower both antibiotic exposure and mortality rates, especially in low-resource settings.
Full answer →Does maternal preeclampsia increase the risk of neonatal sepsis in my baby?
Yes, maternal preeclampsia is linked to a modestly higher risk of neonatal sepsis in the first 28 days of life, based on a large meta-analysis.
Full answer →