Base excess shows 85.8% sensitivity and 82.9% specificity for neonatal sepsis diagnosis in meta-analysis
Base Excess Levels May Help Identify Neonatal Sepsis Risk
This meta-analysis evaluated base excess (BE) for diagnosing and prognosing neonatal sepsis. Pooled sensitivity at ≤-5 mEq/L was 85.8% and s…
A new analysis suggests that measuring base excess levels could help doctors identify and predict risks in infants with neonatal sepsis.
Azithromycin reduces maternal infection in laboring women in low- and middle-income countries
Antibiotic reduces maternal infection risk in labor
This secondary analysis of an RCT found that azithromycin reduced maternal infection and sepsis in women in labor, with a larger reduction a…
A single dose of azithromycin during labor lowered maternal infections in a large trial across seven countries.
Systematic Review and Meta-Analysis Finds IL-27 Superior to CRP for Neonatal Sepsis Diagnosis
A New Blood Test May Spot Newborn Sepsis Faster Than Current Methods
This systematic review and meta-analysis of 495 neonates compared IL-27 to C-reactive protein for diagnosing neonatal sepsis. IL-27 showed h…
A simple blood marker called IL-27 catches newborn sepsis more accurately than the standard test, potentially saving lives by speeding up di…
Weekend births linked to longer antibiotic exposure in very low birth weight infants with suspected sepsis
Weekend births delay antibiotic stops for fragile newborns
This retrospective cohort study examined antibiotic exposure times in very low birth weight infants with suspected early-onset sepsis and ne…
New research shows babies born on weekends stay on antibiotics longer than those born during the work week.
Prophylactic azithromycin during labor increases S. aureus resistance in mothers and infants
Azithromycin in Labor Raises Short-Term Resistance Risk
This RCT sub-study of 911 women and 915 infants found that prophylactic oral azithromycin during labor increased azithromycin resistance in …
This could change how we balance infection protection and antibiotic safety in childbirth.
7-Day Antibiotic Regimen Non-Inferior to 14-Day for Uncomplicated Neonatal Sepsis in RCT
Can shorter antibiotics cure newborn sepsis just as well as two weeks of treatment?
This randomized control assessor-blinded trial evaluated 140 neonates weighing ≥ 1000 g with culture-positive sepsis in a tertiary Neonatal …
A 7-day antibiotic course for newborn sepsis worked as well as 14 days, with babies leaving the hospital sooner and needing less breathing s…
AMR strategies in LMIC newborns reduce antibiotic use and mortality in meta-analysis
Strategies to reduce antibiotic resistance may lower infection risks in newborns in low-income countries
A systematic review and meta-analysis of 31 facility-based studies in LMICs found that strategies to reduce antimicrobial resistance, includ…
Strategies to curb antibiotic resistance in newborns in low-income countries lower infection risks and reduce overall mortality.
Maternal preeclampsia modestly increases neonatal sepsis risk in infants up to 28 days of age
A Mother’s High Blood Pressure May Raise Her Newborn’s Infection Risk
This systematic review and meta-analysis evaluated 1,513,008 neonates to assess the association between maternal preeclampsia and neonatal s…
Babies born to mothers with preeclampsia face a 27% higher risk of serious infection in the first month of life, prompting doctors to watch …
Case-control study identifies K. pneumoniae proteins associated with lack of neonatal sepsis
Study identifies potential vaccine targets for deadly newborn infection in Africa
A case-control study of 100 mother-baby dyads in sub-Saharan Africa analyzed antibody responses to 161 K.
Specific bacterial proteins might protect newborns from deadly sepsis via maternal antibodies, paving the way for a vaccine in sub-Saharan A…
Chlorhexidine May Reduce Neonatal Mortality and Infection in LMICs
Can antiseptics on the umbilical cord save newborns from infection and death?
Meta-analysis shows 4.0% chlorhexidine reduces neonatal mortality (RR 0.86) and omphalitis (RR 0.71) in LMICs, but delays cord separation by…
Applying chlorhexidine to the umbilical cord may lower the risk of infection and death in newborns in low-income countries.
Research across Systemic Inflammatory Response Syndrome
Related studies from across the Systemic Inflammatory Response Syndrome family.
Sivelestat-containing regimens reduce all-cause mortality in sepsis-induced ARDS with OR 0.55
Sivelestat shows lower mortality for patients with sepsis and ARDS
This meta-analysis of 943 patients found that a sivelestat-containing regimen significantly reduced all-cause mortality in sepsis-induced AR…
A new review of data suggests the drug sivelestat may lower death rates for adults with severe lung and blood infections.
High THBS1 expression is associated with poorer outcomes in patients with sepsis
High THBS1 levels linked to poorer outcomes in sepsis patients
This meta-analysis of public datasets and an exploratory cohort identifies THBS1 as a candidate molecule for myeloid immune responses in sep…
A new look at medical data shows that high levels of a specific protein marker may signal a higher risk for sepsis patients.
AI decision support improves detection in bounded tasks but not in open-ended reasoning
AI Tools Show Mixed Results in Cancer and Sepsis Detection
This narrative review examines the impact of AI decision support and large language models on clinician performance in cancer and sepsis. Th…
AI tools may help doctors find more cancer and reduce workload, but they do not improve complex reasoning or always ensure consistent accura…
Heparin Shows No Mortality Benefit in Sepsis Meta-Analysis of 426 Patients
Heparin treatment shows mixed results for patients with sepsis
This meta-analysis examined heparin use in critically ill patients with sepsis, pooling data from 426 patients. No significant mortality red…
New data on heparin for sepsis shows it does not significantly reduce death rates, and its role in blood clotting remains unclear.
MitoQ acts as an upstream mitochondrial redox modulator to attenuate oxidative injury in SALI
MitoQ may protect lung cells from damage during severe infection
This narrative review explores the role of MitoQ in treating sepsis and acute lung injury. The authors suggest MitoQ may mitigate mitochondr…
A new review suggests the compound MitoQ could protect lung tissue and energy production during severe infections like sepsis.
Hemodiafiltration in Neonates: Narrative Review Maps Applications but Reports No Clinical Outcomes
Hemodiafiltration in Babies: What We Still Do Not Know
This narrative review examines hemodiafiltration (HDF) in neonates and infants, focusing on clinical applications, potential benefits, safet…
A new review looks at hemodiafiltration for newborns and infants, but reports no actual results or safety data.
Higher H3.1 nucleosome levels associate with 48% increased 28-day mortality in septic shock
H3.1 Nucleosome Levels Linked to Sepsis Mortality and Kidney Risk
This secondary analysis of a multicenter randomized controlled trial involved 971 patients with sepsis and septic shock. Higher plasma H3.1 …
Higher levels of H3.1 nucleosomes in patients with sepsis and septic shock are linked to a higher risk of death and need for kidney replacem…
Phoenix Sepsis Criteria outperforms IPSCC criteria for pediatric in-hospital mortality risk stratification
New criteria improve risk prediction for children with sepsis
This meta-analysis of 15 studies and 16 cohorts involving 2,601,038 encounters evaluates the Phoenix Sepsis Criteria (PSC) compared to IPSCC…
A new scoring system helps doctors better predict which children with severe infections are at the highest risk of dying in the hospital.
Feasibility study for meropenem versus piperacillin/tazobactam in sepsis shows 30.5% 30-day mortality
Trial Tests Meropenem for Treatment of Sepsis in Critical Care
This feasibility study of 200 critically ill adults with sepsis in 10 Danish ICUs evaluated the trial's operational viability. The study rep…
A new feasibility study explores the use of meropenem to treat critically ill adults suffering from sepsis in intensive care units.
Sepsis-associated delirium affects 43% of ICU patients, mechanical ventilation strongest risk factor
Risk Factors Linked to Delirium in Patients with Sepsis
This meta-analysis of 89,789 ICU patients estimates the pooled incidence of sepsis-associated delirium (SAD) at 43% (95% CI 39%-47%). Higher…
A large review of ICU patients identifies key risk factors, such as advanced age and mechanical ventilation, for developing delirium during …
Elevated BMI is associated with lower short-term and long-term mortality in adult sepsis patients
Higher BMI Linked to Lower Mortality in Patients with Sepsis
This meta-analysis of 130755 patients indicates that an elevated BMI (≥30 kg/m) is associated with significantly lower short-term and long-t…
A large review of data suggests that patients with a higher BMI may have lower mortality rates when treated for sepsis.
Mongolian Medicine Compounds Show Immunomodulatory Potential in Sepsis, But Direct Evidence Remains Scarce
Traditional Mongolian Medicine shows potential for treating sepsis models
This narrative review examines Traditional Mongolian Medicine compounds (Daruqi particles, HHQG, Hohgardi-9, Nagab-9, Monflu, Batri-7, Qiqir…
Traditional Mongolian medicines like quercetin and berberine show potential to manage inflammation in sepsis models, though more human trial…
Questions about Neonatal Sepsis
Does reducing antibiotic use help lower neonatal sepsis mortality rates?
Reducing unnecessary antibiotic use through antimicrobial stewardship strategies in newborns can lower both antibiotic exposure and mortality rates, especially in low-resource settings.
Full answer →Does maternal preeclampsia increase the risk of neonatal sepsis in my baby?
Yes, maternal preeclampsia is linked to a modestly higher risk of neonatal sepsis in the first 28 days of life, based on a large meta-analysis.
Full answer →