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Home › Medications › guanfacine

guanfacine

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of guanfacine

17 trials tracked of guanfacine: 5 in phase 3 or 4 and 5 with published results. The most-cited published study has 85 citations.

17Trials tracked
5Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 4 Phase 3 1 Phase 2 8 Phase 1 1 Other / NA 3
  1. Phase 4 Single Versus Combination Medication Treatment for Children With Attention Deficit Hyperactivity Disorder Completed · 85 cited
  2. Phase 4 Efficacy and Safety Eval of Guanfacine Hydrochloride in Combination With Psychostimulants in Adults (18-65). Completed · 28 cited
  3. Phase 3 The Effect of Guanfacine on Delirium in Critically Ill Patients Completed · 28 cited
  4. Phase 4 Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic Completed · 9 cited
  5. Phase 4 Interventions for Children With Attention and Reading Disorders Completed · 4 cited
  6. Phase 2 Guanfacine to Improve Substance Use Outcomes in Women Completed
Show 11 more trials
  1. Phase 2 Modeling Stress-precipitated Smoking Behavior for Medication Development Completed
  2. Phase 2 Maximizing trEatment of Neurological Dysfunction Using INtravenous Guanfacine Study Completed
  3. Phase 2 Stress and Medication Effects on Cocaine Cue Reactivity Completed
  4. Phase 2 Efficacy of Guanfacine and Lidocaine Combination in Trigeminal Nerve Block for Pain Management in Trigeminal Neuropathy Completed
  5. Phase 2 Guanfacine for the Treatment of Spatial Neglect and Impaired Vigilance Completed
  6. Phase 2 PK/PD Comparison of Guanfacine ER and IR Completed
  7. Phase 2 Guanfacine Clinical Trial for Smoking Cessation Completed
  8. Phase 1 Open-Label Pilot Study of Guanfacine-Extended Release for the Treatment of Cannabis Dependence Completed
  9. N/A Guanfacine for PONV and Pain After Sinus Surgery Completed
  10. N/A Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects Completed
  11. N/A The Effects of Ketamine and Guanfacine on Working Memory in Healthy Subjects Completed

Showing the 17 most-cited and recently-updated of 17 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Multiomic Integration Prioritizes Guanfacine, Eltrombopag, Encorafenib as Alzheimer Repurposing Candidates
Genetics & Precision Medicine Meta-analysis
Multiomic Integration Prioritizes Guanfacine, Eltrombopag, Encorafenib as Alzheimer Repurposing Candidates New data identifies specific cell targets in early Alzheimer's disease
This meta-analysis integrates multiomic data to identify cell-type-specific signatures and pharmacological targets in early Alzheimer's dise…
Researchers used advanced data integration to find specific cell types and pathways that could lead to new ways to treat early Alzheimer's d…
medRxiv Sep 24, 2026
Higher ADHD medication doses improve efficacy up to a threshold before benefits plateau
Pediatrics Meta-analysis
Higher ADHD medication doses improve efficacy up to a threshold before benefits plateau Higher ADHD medication doses often stop working or cause more side effects
This network meta-analysis examined oral monotherapy for ADHD in children, adolescents, and adults. Efficacy generally increased with dose u…
A large network analysis of ADHD drugs shows that increasing doses beyond specific limits usually does not improve symptoms and may increase…
Jun 1, 2026