AI-driven in silico tools enhance sequence design and optimization for monoclonal antibody development
Artificial intelligence speeds up discovery of new antibody treatments
This systematic review evaluates AI-driven in silico tools for the discovery and optimization of monoclonal antibodies across infectious, au…
New computer tools powered by AI help scientists design and optimize antibodies for diseases like cancer and autoimmune disorders faster.
Neuroinflammation-targeted immunotherapy shows no significant benefit in ischemic stroke meta-analysis
Trial Shows Neuroinflammation Therapies Lack Consistent Benefit for Stroke
This meta-analysis of 3 RCTs (637 patients) found no significant pooled clinical benefit for neuroinflammation-targeted immunotherapies in i…
New research into cell and antibody therapies for stroke shows that these treatments do not yet provide a consistent clinical benefit for pa…
Post-marketing data on CGRP inhibitors show paucity of data and additional risks from chronic biologic use
Post-marketing review highlights safety gaps for migraine CGRP drugs
This narrative review examines monoclonal antibodies and Calcitonin Gene-Related Peptide (CGRP) inhibitors for migraine in the post-marketin…
A review of migraine treatments notes limited data on long-term risks for CGRP inhibitors, urging caution during active monitoring.
Narrative review discusses antibody targeting of the TNF–TNFR2 axis in cancer with noted limitations
Antibodies targeting TNFR2 show promise for cancer treatment
This narrative review examines antibody targeting of the TNF–TNFR2 axis, including monoclonal antibodies, antibody–drug conjugates, and bisp…
A narrative review suggests antibodies targeting the TNF–TNFR2 axis may offer new cancer treatment options, though more research is needed.
Meta-analysis finds trivial cognitive effects of amyloid antibodies in mild Alzheimer's disease
Alzheimer’s Drugs Clear Plaques But Don’t Help Memory
This meta-analysis of 17 randomized trials found amyloid-beta-targeting monoclonal antibodies probably have little to no effect on cognitive…
This review shows that even when Alzheimer’s drugs clear amyloid from the brain, patients don’t see meaningful improvements in memory or dai…