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Home › Conditions › Psoriasis

Psoriasis

Subtypes of Psoriasis

Plaque psoriasis 14 Erythrodermic psoriasis 1 Generalized pustular psoriasis 1 Inverse Psoriasis 1

37 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Psoriasis

289 trials tracked for Psoriasis: 148 in phase 3 or 4 and 52 with published results. The most-cited published study has 841 citations.

289Trials tracked
148Phase 3 & 4
0Recruiting
52With published results
Phase distribution
Phase 4 50 Phase 3 98 Phase 2 85 Phase 1 21 Other / NA 35
  1. Phase 3 A Phase 3 Study in Participants With Moderate to Severe Psoriasis Completed · 841 cited
  2. Phase 4 Mechanism of Action Study for Psoriasis Completed · 722 cited
  3. Phase 3 Etanercept (Enbrel®) in Psoriasis - Pediatrics Completed · 388 cited
  4. Phase 3 A Study to Evaluate the Comparative Efficacy of CNTO 1959 (Guselkumab) and Secukinumab for the Treatment of Moderate to Severe Plaque-type Psoriasis Completed · 377 cited
  5. Phase 3 BI 655066/ABBV-066 (Risankizumab) Compared to Active Comparator (Adalimumab) in Patients With Moderate to Severe Chronic Plaque Psoriasis Completed · 299 cited
  6. Phase 3 BI 655066 / ABBV-066 (Risankizumab) in Moderate to Severe Plaque Psoriasis With Randomized Withdrawal and Re-treatment Completed · 216 cited
Show 44 more trials
  1. Phase 3 An Efficacy and Safety Study of Two Dose Levels of Certolizumab Pegol (CZP) in Subjects With Plaque Psoriasis (PSO) Completed · 155 cited
  2. Phase 3 A Study to Evaluate the Efficacy and Safety of Two Dose Levels of Certolizumab Pegol (CZP) in Subjects With Plaque Psoriasis (PSO) Completed · 155 cited
  3. Phase 4 Vascular Inflammation in Psoriasis - Extension Study Completed · 148 cited
  4. Phase 4 Vascular Inflammation in Psoriasis Trial (The VIP Trial) Completed · 147 cited
  5. Phase 3 A Study in Japanese Participants With Moderate-to-Severe Psoriasis Completed · 132 cited
  6. Phase 3 Efficacy and Safety Study of Certolizumab Pegol (CZP) Versus Active Comparator and Placebo in Subjects With Plaque Psoriasis (PSO) Completed · 131 cited
  7. Phase 3 A Study Evaluating The Efficacy And Safety Of CP-690,550 In Asian Subjects With Moderate To Severe Plaque Psoriasis Completed · 87 cited
  8. Phase 3 Randomized Placebo-controlled Study of ISA247 in Plaque Psoriasis Completed · 87 cited
  9. Phase 3 Study to Compare Efficacy and Safety of ABP 501 and Adalimumab (HUMIRA®) in Adults With Moderate to Severe Plaque Psoriasis Completed · 82 cited
  10. Phase 3 A Study of Guselkumab in the Treatment of Participants With Moderate to Severe Plaque-Type Psoriasis With Randomized Withdrawal and Retreatment Completed · 82 cited
  11. Phase 3 A Study to Evaluate Further Therapeutic Strategies With Guselkumab in Participants With Moderate-to-Severe Plaque-Type Psoriasis Completed · 81 cited
  12. Phase 3 A Study of Ustekinumab to Evaluate a "Subject-tailored" Maintenance Dosing Approach in Subjects With Moderate-to-Severe Plaque Psoriasis Completed · 71 cited
  13. Phase 3 A Study in Participants With Moderate to Severe Psoriasis (UNCOVER-3) Completed · 69 cited
  14. Phase 3 Efficacy and Safety Study of Guselkumab in the Treatment of Participants With Moderate to Severe Plaque-Type Psoriasis Completed · 56 cited
  15. Phase 3 A Study of Guselkumab in Participants With Moderate to Severe Plaque-type Psoriasis and an Inadequate Response to Ustekinumab Completed · 56 cited
  16. Phase 3 Apremilast as a Direct Treatment for Mild-to-moderate Plaque Psoriasis Versus Placebo: an Analysis of Clinical Safety and Efficacy Completed · 56 cited
  17. Phase 3 A Study of Guselkumab in the Treatment of Participants With Moderate to Severe Plaque-Type Psoriasis Completed · 55 cited
  18. Phase 3 BI 655066 (Risankizumab) Compared to Placebo and Active Comparator (Ustekinumab) in Patients With Moderate to Severe Chronic Plaque Psoriasis Completed · 54 cited
  19. Phase 3 BI 655066 Versus Placebo & Active Comparator (Ustekinumab) in Patients With Moderate to Severe Chronic Plaque Psoriasis Completed · 54 cited
  20. Phase 3 A Study to Assess the Safety and Efficacy of Risankizumab for Maintenance in Moderate to Severe Plaque Type Psoriasis ( LIMMITLESS ) Completed · 49 cited
  21. Phase 3 A Study of the Efficacy and Safety of Apremilast (CC-10004) in Subjects With Moderate to Severe Plaque Psoriasis of the Scalp Completed · 48 cited
  22. Phase 4 Vascular Inflammation in Psoriasis - Apremilast Completed · 44 cited
  23. Phase 3 An Investigational Study to Evaluate Experimental Medication BMS-986165 Compared to Placebo and a Currently Available Treatment in Participants With Moderate-to-Severe Plaque Psoriasis Completed · 41 cited
  24. Phase 3 Effectiveness and Safety of BMS-986165 Compared to Placebo and Active Comparator in Participants With Psoriasis Completed · 41 cited
  25. Phase 3 Study of the Drug Efalizumab (Raptiva), for Adult Patients With Moderate to Severe Plaque Psoriasis Completed · 33 cited
  26. Phase 3 A Study to Assess if Mirikizumab is Effective and Safe Compared to Secukinumab and Placebo in Moderate to Severe Plaque Psoriasis (OASIS-2) Completed · 29 cited
  27. Phase 3 A Study to Compare the Efficacy and Safety of CT-P43 to Stelara in Patients With Plaque Psoriasis Completed · 27 cited
  28. Phase 3 The VOLTAIRE-X Trial Looks at the Effect of Switching Between Humira® and BI 695501 in Patients With Plaque Psoriasis Completed · 27 cited
  29. Phase 3 An Efficacy and Safety Study of Apremilast (CC-10004) in Subjects With Moderate to Severe Genital Psoriasis Completed · 27 cited
  30. Phase 3 Risankizumab Versus Secukinumab for Participants With Moderate to Severe Plaque Psoriasis Completed · 26 cited
  31. Phase 4 Study of Subcutaneous Risankizumab Injection Compared to Oral Apremilast Tablets to Assess Change in Disease Activity And Adverse Events in Adult Participants With Moderate Plaque Psoriasis Who Are Candidates for Systemic Therapy Completed · 22 cited
  32. Phase 3 A Study to Assess Efficacy and Safety of Two Different Dose Regimens of Risankizumab Administered Subcutaneously in Japanese Subjects With Generalized Pustular Psoriasis or Erythrodermic Psoriasis Completed · 20 cited
  33. Phase 3 Efficacy, Safety and Immunogenicity of BI 695501 Versus Humira® in Patients With Moderate to Severe Chronic Plaque Psoriasis Completed · 20 cited
  34. Phase 3 An Efficacy, Safety, and Pharmacokinetics Study of Subcutaneously Administered Ustekinumab in the Treatment of Moderate to Severe Chronic Plaque Psoriasis in Pediatric Participants Greater Than or Equal to 6 to Less Than 12 Years of Age Completed · 18 cited
  35. Phase 3 Study of Secukinumab With 2 mL Pre-filled Syringes Completed · 18 cited
  36. Phase 3 A Study to Assess Safety and Efficacy of Risankizumab Using a New Formulation in Participants With Moderate to Severe Plaque Psoriasis Completed · 16 cited
  37. Phase 4 A Study of Efalizumab in Participants With Moderate to Severe Chronic Psoriasis Who Have Failed, Have a Contraindication to, or Are Intolerant of Other Systemic Therapies Completed · 14 cited
  38. Phase 3 A Phase 3 Study in Participants With Moderate to Severe Psoriasis (UNCOVER-2) Completed · 13 cited
  39. Phase 3 A Study to Evaluate the Efficacy and Safety of Mirikizumab (LY3074828) in Participants With Moderate-to-Severe Plaque Psoriasis Completed · 12 cited
  40. Phase 4 A Multicentre, Open Label Phase IIIb/IV Study of Subcutaneously Administered Raptiva in the Treatment of Adult Subjects With Moderate to Severe Plaque Psoriasis Completed · 10 cited
  41. Phase 3 A Comparison of DFD01 Spray Versus Comp01 Lotion, Vehicle Spray and Vehicle Lotion in Subjects With Moderate Psoriasis Completed · 4 cited
  42. Phase 3 An Investigational Study to Evaluate Experimental Medication BMS-986165 Compared to Placebo in Participants With Plaque Psoriasis (POETYK-PSO-3) in Mainland China, Taiwan, and South Korea Completed · 3 cited
  43. Phase 3 An Investigational Study to Evaluate Experimental Medication BMS-986165 in Japanese Participants With Moderate-to-Severe Psoriasis Completed · 3 cited
  44. Phase 4 A Real World Study Evaluating the Long-Term Quality of Life of Tildrakizumab in Adult Patients With Psoriasis Completed · 2 cited

Showing the 50 most-cited and recently-updated of 289 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Psoriasis: what the trials found

Secukinumab showed no significant difference in PASI 90 at week 28 compared to placebo (p=0.3857) but demonstrated a significant difference in PASI 75 over time (p=0.0300) 1. Risankizumab significantly improved PASI 90 and sPGA 0/1 at week 16 versus placebo (both p<0.001) 7. Deucravacitinib significantly improved DLQI 0/1, DLQI ≥4 reduction, and itch NRS at week 16 (p=0.0001 to p<0.0001) 14, and significantly improved scalp-specific outcomes (Ss-PGA 0/1, PSSI 90, scalp itch NRS) at week 16 (all p<0.0001) 16. Apremilast significantly improved DLQI ≥4 reduction and DLQI change at week 16 (p<0.0001) and BSA percent change (p=0.0085) 11. Tildrakizumab significantly improved quality of life (PGWB and DLQI) over time (p<0.001 to p=0.011) 10. Methotrexate showed significant improvement in biologic activity endpoints (p<0.05) and clinical endpoints (PASI 75: 67% vs 27%; PGA 0-1: 73% vs 27%) 3. Efalizumab resulted in 68% of patients achieving PGA good or better, with 11% rebound and 12.9% exacerbation 8; another trial reported 46% achieving PGA excellent or cleared at week 24 9. Tapinarof cream 1% led to 23% of patients achieving target lesion PGA clear/almost clear in head/neck 17 and 24% achieving intertriginous PGA clear/almost clear 18. Adalimumab showed no significant change in vascular inflammation or cardiometabolic biomarkers (p>0.05) 4. Apremilast showed no significant change in aortic vascular inflammation (p=0.612) or cardiometabolic markers (CRP p=0.617, ferritin p=0.083) 6. Tildrakizumab showed minimal change in coronary flow reserve (-0.03) and no significant correlation with skin severity (p=0.35) 13. Metaderm improved sPGA*BSA (53.06% vs 65.6%) and DLQI (52.88% vs 17.82%) 21. Apremilast improved nail psoriasis (mNAPSI mean percent change 64.1% at week 36, p=0.05) and nail pain VAS (-50.42%) 22. Secukinumab improved itch, pain, and PASI scores (change: 3, 2, 8 respectively) 15.

Recent results — preliminary, needs further review

  • Orticumab (phase 2, N=77) showed variable mean percent change in PASI across doses (-3.46 to -20.14) and low rates of PASI75/PASI50 (0-51%) and sIGA success (1 participant per group) 2.

For the clinician treating this condition

  • Risankizumab, deucravacitinib, and apremilast demonstrate significant improvements in skin clearance and quality of life measures.
  • Biologics like secukinumab and tildrakizumab also improve quality of life, though secukinumab's PASI 90 at week 28 was not significant.
  • Methotrexate remains effective for clinical endpoints, while apremilast shows benefit for nail psoriasis.
  • Cardiovascular outcomes with adalimumab, apremilast, and tildrakizumab did not show significant changes.

AI synthesis of 18 cited trials, updated Jun 20, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Guselkumab, Secukinumab, and Brodalumab rank highly for PASI 75 and PASI 90 in plaque psoriasis
Oncology Meta-analysis
Guselkumab, Secukinumab, and Brodalumab rank highly for PASI 75 and PASI 90 in plaque psoriasis New data ranks different treatments for moderate to severe psoriasis
This systematic review and network meta-analysis of 27 RCTs evaluated IL-23/IL-17 inhibitors for moderate-to-severe plaque psoriasis. Guselk…
Comparing several types of biologics helps patients with plaque psoriasis find which medications rank highest for clearing skin and improvin…
Frontiers Jul 26, 2026
Obesity is associated with lower PASI90, PASI75, and PASI100 responses in patients with psoriasis
Diabetes & Endocrinology Meta-analysis
Obesity is associated with lower PASI90, PASI75, and PASI100 responses in patients with psoriasis Obesity May Impact How Well Certain Psoriasis Drugs Work
This meta-analysis of 4200 patients found that obesity is associated with lower PASI90 (RR = 0.64), PASI75 (RR = 0.52), and PASI100 (RR = 0.…
New data suggests that patients with obesity may see lower response rates to certain biologic treatments for psoriasis.
Jul 22, 2026
Calcium signaling dysregulation drives keratinocyte defects and immune activation in psoriasis
Allergy & Immunology Sys. Review
Calcium signaling dysregulation drives keratinocyte defects and immune activation in psoriasis Calcium signaling problems may drive the cycle of psoriasis
This systematic review synthesizes evidence that impaired calcium sensing and SOCE dysfunction in keratinocytes, alongside persistently acti…
New research identifies how faulty calcium signals in skin cells and immune cells could be a key driver of psoriasis symptoms.
Frontiers Jul 15, 2026
Combination therapies of plant-derived compounds outperform monotherapy for psoriasis vulgaris with specific immunological profiles
Rheumatology Meta-analysis
Combination therapies of plant-derived compounds outperform monotherapy for psoriasis vulgaris with specific immunological profiles Plant compounds combined with standard care improve psoriasis symptoms
This systematic review and network meta-analysis of 84 randomized controlled trials involving 7,544 patients found that combination therapie…
Combining specific plant-derived ingredients with standard treatments may offer better results for people living with psoriasis.
Frontiers Jun 22, 2026
SSGJ-608 achieves 92.7% to 95.1% PASI75 response in moderate-to-severe plaque psoriasis
Dermatology Phase III
SSGJ-608 achieves 92.7% to 95.1% PASI75 response in moderate-to-severe plaque psoriasis New injection shows promise for moderate to severe plaque psoriasis
This phase 3 randomized trial in 770 patients with moderate-to-severe plaque psoriasis found that SSGJ-608 (80mg every 2 weeks or 160mg ever…
A new injectable treatment showed high success rates in clearing skin and improving appearance for people with plaque psoriasis.
Frontiers Jun 10, 2026
Staphylococcal infections may mimic paradoxical psoriasis in patients receiving TNF-alpha inhibitors for systemic conditions
Allergy & Immunology Sys. Review
Staphylococcal infections may mimic paradoxical psoriasis in patients receiving TNF-alpha inhibitors for systemic conditions Skin infections can mimic psoriasis during certain medical treatments
This case report series describes 6 patients treated with TNF-alpha antagonists who developed skin lesions initially misdiagnosed as paradox…
Some patients treated for skin conditions may actually have a bacterial infection that looks like a flare-up of their original condition.
Frontiers Jun 9, 2026
Smoking and alcohol linked to higher psoriasis risk in large meta-analysis
Primary Care & Family Medicine Meta-analysis
Smoking and alcohol linked to higher psoriasis risk in large meta-analysis Smoking raises psoriasis risk significantly while alcohol shows a smaller effect
This systematic review and meta-analysis of observational studies involving more than 25 million participants found that smoking (RR 1.67) a…
Smoking increases the chance of developing psoriasis, and even quitting keeps that risk higher than never smoking. Alcohol also plays a role…
Frontiers Jun 7, 2026
High-certainty evidence suggests weight-loss interventions improve psoriasis severity and quality of life in adults
Dermatology Meta-analysis
High-certainty evidence suggests weight-loss interventions improve psoriasis severity and quality of life in adults Weight loss linked to better psoriasis severity and quality of life
This systematic review and meta-analysis evaluated weight-loss interventions versus usual care or lower-intensity interventions in adults wi…
A review of 1,145 adults with psoriasis found weight-loss interventions improved skin severity and quality of life more than usual care.
Jun 1, 2026
Icotrokinra 200 mg daily achieves PASI 75 in 73% of patients at Week 16 versus 11% with placebo in moderate-to-severe plaque psoriasis
Dermatology Meta-analysis
Icotrokinra 200 mg daily achieves PASI 75 in 73% of patients at Week 16 versus 11% with placebo in moderate-to-severe plaque psoriasis Oral icotrokinra shows strong results for moderate-to-severe plaque psoriasis
This systematic review and meta-analysis evaluates icotrokinra for moderate-to-severe plaque psoriasis in 1951 patients. The pooled analysis…
A new analysis finds oral icotrokinra helps clear skin faster than placebo in patients with moderate-to-severe plaque psoriasis.
Jun 1, 2026
Switching between adalimumab and biosimilar adalimumab-atto shows similar pharmacokinetics in plaque psoriasis
Dermatology RCT
Switching between adalimumab and biosimilar adalimumab-atto shows similar pharmacokinetics in plaque psoriasis Switching between adalimumab and its biosimilar is safe and similar
This phase 3 RCT in 425 adults with moderate-to-severe plaque psoriasis found that multiple switches between adalimumab RP and biosimilar ad…
A new trial shows that switching between adalimumab and its biosimilar adalimumab-atto is safe and produces similar drug levels in the blood…
Jun 1, 2026
Narrative review offers theoretical basis for selecting biologic therapies in psoriasis patients with renal concerns
Dermatology Sys. Review
Narrative review offers theoretical basis for selecting biologic therapies in psoriasis patients with renal concerns New Psoriasis Treatments May Protect Kidneys While Fighting Skin Flares
This narrative review examines the use of TNF-alpha, IL-17, and IL-12/23 inhibitors in psoriasis patients with renal concerns. The authors p…
• Some biologics shield kidneys from damage during psoriasis treatment • Helps the 8 million Americans with psoriasis and kidney worries • N…
Frontiers May 5, 2026
Targeted therapies for psoriasis and psoriatic arthritis significantly alter lipid profiles across diverse patient populations
Dermatology Meta-analysis
Targeted therapies for psoriasis and psoriatic arthritis significantly alter lipid profiles across diverse patient populations Psoriasis drugs change heart risk in surprising ways
A comprehensive meta-analysis of 24,575 patients reveals that targeted therapies for psoriasis and psoriatic arthritis consistently modify l…
Some common psoriasis drugs sharply raise cholesterol while others lower it, forcing doctors to rethink how they protect their patients’ hea…
May 2, 2026

Questions about Psoriasis

Are there regional differences in health issues for people with psoriasis?

Yes, regional differences exist in psoriasis-related health issues, including comorbidities, treatment patterns, and healthcare access, as shown by studies from North America, Europe, Asia, and Africa.

Full answer →
Is secukinumab effective for Chinese patients with psoriatic arthritis?

Yes, secukinumab is effective for Chinese patients with psoriatic arthritis, with real-world data and cost-effectiveness analyses supporting its use.

Full answer →

All Psoriasis Articles