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Home › Medications › nitrous oxide

nitrous oxide

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of nitrous oxide

9 trials tracked of nitrous oxide: 5 in phase 3 or 4.

9Trials tracked
5Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 4 3 Phase 3 2 Phase 2 2 Other / NA 2
  1. Phase 4 Dexmedetomidine and Propofol for Pediatric MRI Sedation Completed
  2. Phase 4 A Comparison of Intranasal Midazolam and Nitrous Oxide (N2O) Minimal Sedation for Minor Procedures in a Pediatric Emergency Department Completed
  3. Phase 4 Effect of Nitrous Oxide (N2O) on Intraocular Pressure in Healthy Volunteers Completed
  4. Phase 3 Nitrous Oxide for External Cephalic Version Completed
  5. Phase 3 Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome Completed
  6. Phase 2 Exploring Nitrous Oxide Effects for Post Traumatic Stress Disorder (PTSD) Completed
Show 3 more trials
  1. Phase 2 Nitrous Oxide as Treatment for Major Depression - a Pilot Study Completed
  2. N/A Nitrous Oxide Versus Intravenous Sedation for Anesthesia Completed
  3. N/A Nitrous Oxide Use in Minor Procedures Completed

Showing the 9 most-cited and recently-updated of 9 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Nitrous oxide reduces pain and improves completion rates in office hysteroscopy
Anesthesiology & Pain Medicine RCT
Nitrous oxide reduces pain and improves completion rates in office hysteroscopy Nitrous oxide reduces pain during office hysteroscopy procedures
This single-center RCT of 214 women found that inhaled nitrous oxide significantly reduced intraprocedural pain and improved procedure compl…
Inhaled nitrous oxide significantly lowers pain and improves patient satisfaction for women undergoing office operative hysteroscopy.
Jul 6, 2026
Case report details vitamin B12 treatment for nitrous oxide induced neurological damage
Psychiatry Sys. Review
Case report details vitamin B12 treatment for nitrous oxide induced neurological damage Nitrous oxide linked to lasting brain fog and nerve damage
This case report describes a patient with protracted encephalopathy associated with nitrous oxide use who received vitamin B12 supplementati…
Chronic nitrous oxide use can cause lasting brain fog and nerve damage, and a new case report shows vitamin B12 may help but long-term plans…
Frontiers May 15, 2026