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Home › Medications › olezarsen

olezarsen

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of olezarsen

2 trials tracked of olezarsen: 1 in phase 3 or 4 and 1 with published results. The most-cited published study has 225 citations.

2Trials tracked
1Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 3 1 Phase 2 1
  1. Phase 3 A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) Administered to Patients With Familial Chylomicronemia Syndrome (FCS) Completed · 225 cited
  2. Phase 2 A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Adults With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), and/or With Severe Hypertriglyceridemia Completed

Showing the 2 most-cited and recently-updated of 2 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Olezarsen showed no significant difference versus placebo in noncalcified plaque volume change over 12 months in adults with moderate hypertriglyceridemia
Cardiology RCT
Olezarsen showed no significant difference versus placebo in noncalcified plaque volume change over 12 months in adults with moderate hypertriglyceridemia New trial shows olezarsen did not reduce plaque volume compared to placebo in adults with high triglycerides
This randomized, placebo-controlled trial enrolled 468 adults with moderate hypertriglyceridemia and followed them for 12 months. The primar…
A study of 468 adults found that taking olezarsen did not lower plaque volume better than taking a dummy pill. Safety was also similar betwe…
May 19, 2026
Narrative review on managing hypertriglyceridemia in pregnancy, including olezarsen and volanesorsen
Diabetes & Endocrinology Sys. Review
Narrative review on managing hypertriglyceridemia in pregnancy, including olezarsen and volanesorsen High Triglycerides In Pregnancy Need New Safe Drug Options Soon
This narrative review synthesizes evidence on hypertriglyceridemia in pregnancy. It covers lifestyle and pharmacologic options, noting trigl…
Pregnant women with very high triglycerides face dangerous risks but safe new drugs are not yet approved for use during delivery.
Frontiers May 8, 2026