Pharmacist-led medication therapy management improves adherence and glycemic control in a patient with complex T2DM
Pharmacist-led care improves blood sugar for woman with long-term diabetes
This case report describes a single patient with type 2 diabetes who received pharmacist-led medication therapy management. The intervention…
A pharmacist-led review helped a woman with a 30-year history of Type 2 Diabetes significantly improve her medication adherence and blood su…
Olezarsen showed no significant difference versus placebo in noncalcified plaque volume change over 12 months in adults with moderate hypertriglyceridemia
New trial shows olezarsen did not reduce plaque volume compared to placebo in adults with high triglycerides
This randomized, placebo-controlled trial enrolled 468 adults with moderate hypertriglyceridemia and followed them for 12 months. The primar…
A study of 468 adults found that taking olezarsen did not lower plaque volume better than taking a dummy pill. Safety was also similar betwe…
Narrative review outlines practical framework for combined lipid and anti-inflammatory therapy in coronary atherosclerosis
Your Heart Has a Hidden Fire
This narrative review examines the role of colchicine and IL-1β inhibitors in patients with coronary atherosclerosis.
Doctors now know you must fight two enemies at once: the bad fats in your blood and the hidden inflammation that makes them dangerous.
Narrative mini-review discusses mechanisms driving coronary atherosclerosis in patients with systemic lupus erythematosus
Why Lupus Can Speed Up Heart Disease, Even in Young People
This narrative mini-review synthesizes mechanistic insights regarding the link between systemic lupus erythematosus and coronary atheroscler…
Understanding how lupus harms blood vessels could help prevent heart attacks in people who don’t look high-risk.
Colchicine reduces total plaque burden but not low attenuation plaque in stable CAD patients
Can a cheap anti-inflammatory drug slow heart disease? It might help reduce plaque buildup
In the EKSTROM RCT (n=84), low-dose colchicine (0.5 mg/day) did not significantly reduce low attenuation plaque volume (median change 0.1 vs…
A cheap anti-inflammatory drug called colchicine may help slow total plaque buildup in arteries for people already managing stable heart dis…
Research across Myocardial ischemia
Related studies from across the Myocardial ischemia family.
Impact of Routine Functional Testing on Clinical Outcomes in Patients with Coronary Artery Disease
Routine Stress Testing Does Not Reduce Heart Risk After Procedure
Routine functional testing at one year post-PCI did not improve clinical outcomes but led to a higher rate of invasive procedures.
Routine stress testing after heart procedures did not lower the risk of death or heart attacks, but it did lead to more invasive medical pro…
Higher Triglyceride-glucose index increases MACE risk in patients undergoing coronary artery bypass grafting
Higher Triglyceride-Glucose Index Linked to Risks After Heart Surgery
This meta-analysis of 5,978 patients found that a higher Triglyceride-glucose index (TyG) is associated with a 62.4% higher hazard of MACE p…
A higher triglyceride-glucose index is linked to a higher risk of major heart events and death in patients following heart bypass surgery.
Acupuncture improves cardiac function and reduces MACE risk in patients after percutaneous coronary intervention
Acupuncture shows promise for heart function after coronary procedures
This meta-analysis of 759 patients suggests acupuncture may improve cardiac function and reduce major adverse cardiovascular events followin…
Acupuncture may improve heart function and walking distance for patients recovering from procedures to treat coronary artery disease.
Bayesian analysis of P2Y12 inhibitors identifies clinical uncertainties and equivalence in acute coronary syndromes
Trial Shows Prasugrel May Offer Benefits Over Clopidogrel for Heart Patients
This meta-analysis of 60,619 patients following percutaneous coronary intervention evaluates P2Y12 inhibitors using a Bayesian framework. Th…
A large analysis of over 60,000 patients suggests prasugrel may be more effective than clopidogrel for preventing major heart events after p…
Near-Styloid puncture improves first-attempt success and reduces access-site complications in coronary angiography
Near-Styloid Puncture May Improve Success in Heart Procedures
This randomized controlled trial of 380 patients undergoing coronary angiography found that near-styloid puncture significantly improved fir…
A new puncture location for heart procedures may improve success rates and reduce complications like bruising or artery blockage.
Clopidogrel monotherapy reduces bleeding risk to 2.1% versus 3.2% in patients with acute coronary syndromes
Trial shows clopidogrel alone reduces bleeding risk after heart procedures
This prespecified subgroup analysis of a randomized controlled trial involving 7758 patients with acute coronary syndromes found that clopid…
Patients with heart conditions may face fewer bleeding risks by switching to clopidogrel alone after a period of dual therapy.
Sirolimus-Eluting Balloon with Provisional Stenting for Small to Medium Coronary Arteries
Trial shows sirolimus-eluting balloon is comparable to standard stents
A randomized trial demonstrates that sirolimus-eluting balloon treatment is noninferior to systematic DES for target vessel failure in speci…
A new trial shows that a sirolimus-eluting balloon is as effective as standard stents for treating specific coronary artery blockages.
Evaluating Stepwise Dual Antiplatelet Therapy De-escalation in Patients Following Drug-Coated Balloon Angioplasty
Trial Shows Stepwise DAPT De-escalation for Coronary Heart Disease
A prespecified subgroup analysis of the REC-CAGEFREE II trial evaluates the safety of DAPT de-escalation in ACS patients undergoing DCB-only…
New data shows that switching to a simpler blood thinner regimen may be as safe as standard treatment for patients with coronary artery dise…
Impact of Percutaneous Coronary Intervention Complexity on Ticagrelor or Prasugrel Monotherapy Efficacy
Complex heart procedures do not change risks of certain medications
A post hoc analysis of the NEO-MINDSET trial evaluates if PCI complexity influences the safety and efficacy of potent P2Y inhibitor monother…
New analysis shows that complex heart procedures do not change the safety or effectiveness of specific blood-thinning medications.
Impact of Early Aspirin Withdrawal on Myocardial Infarction in Patients After PCI
Aspirin withdrawal shortly after heart procedures may increase heart attack risk
Early aspirin withdrawal within 30 days post-PCI significantly increases myocardial infarction risk, despite long-term reductions in bleedin…
Stopping aspirin within 30 days of a heart procedure may increase the risk of a heart attack in the first month.
Speckle-tracking echo detects coronary artery disease with 77% sensitivity and 75% specificity
Echocardiography Shows Moderate Accuracy for Detecting Coronary Artery Disease
This meta-analysis of 40 non-randomized studies (5,296 participants) found that speckle-tracking echocardiography (STE) has moderate diagnos…
A review of 40 studies shows that speckle-tracking echocardiography can help identify coronary artery disease with moderate accuracy.
Noninferiority of Ultra-thin Biodegradable Polymer Sirolimus Eluting Stents in Diabetic Patients
New stent type shows promise for patients with diabetes and heart disease
A multicenter trial confirms that ultra-thin biodegradable polymer sirolimus-eluting stents meet noninferiority goals compared to durable po…
A new ultra-thin stent may offer a reliable option for people with both diabetes and complex heart disease.
Questions about Coronary Atherosclerosis
How do combined lipid and anti-inflammatory therapies work for coronary atherosclerosis?
Combined therapies work by lowering LDL cholesterol while simultaneously reducing the chronic inflammation that drives plaque growth and rupture.
Full answer →What is the practical framework for treating coronary atherosclerosis?
Treating coronary atherosclerosis now requires a dual-axis framework that lowers lipids and targets inflammation, moving beyond just fixing blocked arteries to stabilizing the plaque itself.
Full answer →Can colchicine help reduce plaque in coronary atherosclerosis?
Yes, colchicine can help reduce plaque in coronary atherosclerosis by lowering inflammation, though evidence on direct plaque volume reduction is mixed.
Full answer →How does systemic lupus erythematosus affect coronary atherosclerosis?
Systemic lupus erythematosus causes premature coronary atherosclerosis through chronic inflammation, dysfunctional lipoproteins, and specific immune pathways that accelerate plaque buildup beyond traditional risk factors.
Full answer →