Narrative review outlines practical framework for combined lipid and anti-inflammatory therapy in coronary atherosclerosis
Your Heart Has a Hidden Fire
This narrative review examines the role of colchicine and IL-1β inhibitors in patients with coronary atherosclerosis.
Doctors now know you must fight two enemies at once: the bad fats in your blood and the hidden inflammation that makes them dangerous.
Narrative mini-review discusses mechanisms driving coronary atherosclerosis in patients with systemic lupus erythematosus
Why Lupus Can Speed Up Heart Disease, Even in Young People
This narrative mini-review synthesizes mechanistic insights regarding the link between systemic lupus erythematosus and coronary atheroscler…
Understanding how lupus harms blood vessels could help prevent heart attacks in people who don’t look high-risk.
Colchicine reduces total plaque burden but not low attenuation plaque in stable CAD patients
Can a cheap anti-inflammatory drug slow heart disease? It might help reduce plaque buildup
In the EKSTROM RCT (n=84), low-dose colchicine (0.5 mg/day) did not significantly reduce low attenuation plaque volume (median change 0.1 vs…
A cheap anti-inflammatory drug called colchicine may help slow total plaque buildup in arteries for people already managing stable heart dis…
Research across Myocardial ischemia
Related studies from across the Myocardial ischemia family.
IVUS-guided PCI did not significantly reduce target-vessel failure compared to angiography-guided PCI
Trial shows IVUS guidance does not reduce risk for heart patients
This randomized controlled trial of 2020 patients undergoing complex PCI found that IVUS-guided PCI with stent-optimization criteria resulte…
New data suggests that using special ultrasound imaging during complex heart procedures may not lower the risk of major complications.
IVUS-guided PCI shows no significant difference over angiography-guided PCI for primary outcomes
Trial shows ultrasound imaging adds no benefit for heart surgery
This randomized controlled trial of 806 patients with unprotected left main coronary artery disease found that IVUS-guided PCI did not signi…
A large trial found that using ultrasound guidance during certain heart procedures did not improve safety or outcomes compared to standard m…
Pre-transplant coronary artery disease increases all-cause mortality and post-transplant cardiovascular events in kidney recipients
Pre-existing heart disease increases risks for kidney transplant patients
This meta-analysis of 112,416 kidney transplant recipients found that pre-existing coronary artery disease (CAD) is associated with signific…
Patients with pre-existing coronary artery disease face significantly higher risks of death and graft failure after receiving a kidney trans…
High-intensity interval aerobic exercise improves brachial FMD in coronary artery disease and heart failure
High intensity interval training improves blood flow in heart patients
This network meta-analysis of 6,818 adults with coronary artery disease or chronic heart failure found that high-intensity interval aerobic …
Specific types of intense exercise may improve blood vessel function for people living with heart failure or coronary artery disease.
Higher pan-immune-inflammation value linked to worse outcomes after PCI for ACS
High inflammation scores predict worse heart outcomes in patients with acute coronary syndrome
This systematic review and meta-analysis of 18,715 adults with acute coronary syndrome undergoing PCI found that higher pan-immune-inflammat…
A new analysis shows higher inflammation markers predict death and heart failure in adults with acute coronary syndrome undergoing heart pro…
Colchicine reduces major adverse cardiovascular events in coronary artery disease without increasing serious adverse events
Low-dose colchicine reduces heart attack risk for coronary artery disease patients
This systematic review and meta-analysis evaluated colchicine in patients with coronary artery disease and acute coronary syndromes. The ana…
A large analysis shows low-dose colchicine lowers major heart events for coronary artery disease patients without increasing serious risks, …
Staged revascularization shows no significant difference versus immediate revascularization for major adverse cardiovascular events in STEMI and MVD patients
Timing of heart surgery does not change survival for a specific heart attack group
This meta-analysis reviewed 5077 patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease comparing …
A large review found that waiting for staged heart surgery did not improve survival or reduce heart attacks compared to immediate surgery fo…
Sirolimus and paclitaxel-coated balloons show similar outcomes for coronary in-stent restenosis
Sirolimus and paclitaxel balloons show similar results for heart disease
This GRADE-assessed systematic review and meta-analysis of 3,633 participants with coronary artery disease found no notable variations betwe…
Two drug-coated balloons for coronary artery disease work about equally well, a new analysis finds.
Polymer-free and biodegradable-polymer drug-eluting stents show comparable outcomes in PCI
New review shows polymer-free stents work like biodegradable ones for heart patients
A meta-analysis compared polymer-free drug-eluting stents (PF-DES) with biodegradable-polymer drug-eluting stents (BP-DES) in patients under…
A large study of over 11,000 patients found that polymer-free stents are just as safe as older biodegradable ones. Doctors saw no major diff…
Breast arterial calcification on mammography predicts higher cardiovascular event risk in women
Calcium on mammograms signals higher heart risk for women
This systematic review and meta-analysis evaluated breast arterial calcification (BAC) in women across approximately 25,000 participants in …
Calcium seen on mammograms links to higher heart attack risk in women. This large review found a strong connection between breast arterial c…
Mini review examines sudden cardiac death risks in marathon runners across different age groups
Marathon running links to higher heart risk in older men and full-distance participants
This mini review synthesizes evidence on sudden cardiac death (SCD) and coronary artery disease in marathon runners. The authors note that r…
A review of marathon runners shows heart risks vary by age, sex, and race distance, with most events happening near the finish.
Serum resistin levels rise progressively with worsening severity of coronary heart disease and acute myocardial infarction in this meta-analysis
High blood resistin levels linked to heart disease severity in large analysis
A network meta-analysis of 9,169 subjects reveals that serum resistin levels increase stepwise as coronary heart disease severity worsens. W…
A large network meta-analysis found that higher serum resistin levels are linked to worse coronary heart disease and acute heart attacks.
Questions about Coronary Atherosclerosis
How do combined lipid and anti-inflammatory therapies work for coronary atherosclerosis?
Combined therapies work by lowering LDL cholesterol while simultaneously reducing the chronic inflammation that drives plaque growth and rupture.
Full answer →What is the practical framework for treating coronary atherosclerosis?
Treating coronary atherosclerosis now requires a dual-axis framework that lowers lipids and targets inflammation, moving beyond just fixing blocked arteries to stabilizing the plaque itself.
Full answer →Can colchicine help reduce plaque in coronary atherosclerosis?
Yes, colchicine can help reduce plaque in coronary atherosclerosis by lowering inflammation, though evidence on direct plaque volume reduction is mixed.
Full answer →How does systemic lupus erythematosus affect coronary atherosclerosis?
Systemic lupus erythematosus causes premature coronary atherosclerosis through chronic inflammation, dysfunctional lipoproteins, and specific immune pathways that accelerate plaque buildup beyond traditional risk factors.
Full answer →