Olezarsen showed no significant difference versus placebo in noncalcified plaque volume change over 12 months in adults with moderate hypertriglyceridemia
New trial shows olezarsen did not reduce plaque volume compared to placebo in adults with high triglycerides
This randomized, placebo-controlled trial enrolled 468 adults with moderate hypertriglyceridemia and followed them for 12 months. The primar…
A study of 468 adults found that taking olezarsen did not lower plaque volume better than taking a dummy pill. Safety was also similar betwe…
Narrative review outlines practical framework for combined lipid and anti-inflammatory therapy in coronary atherosclerosis
Your Heart Has a Hidden Fire
This narrative review examines the role of colchicine and IL-1β inhibitors in patients with coronary atherosclerosis.
Doctors now know you must fight two enemies at once: the bad fats in your blood and the hidden inflammation that makes them dangerous.
Narrative mini-review discusses mechanisms driving coronary atherosclerosis in patients with systemic lupus erythematosus
Why Lupus Can Speed Up Heart Disease, Even in Young People
This narrative mini-review synthesizes mechanistic insights regarding the link between systemic lupus erythematosus and coronary atheroscler…
Understanding how lupus harms blood vessels could help prevent heart attacks in people who don’t look high-risk.
Colchicine reduces total plaque burden but not low attenuation plaque in stable CAD patients
Can a cheap anti-inflammatory drug slow heart disease? It might help reduce plaque buildup
In the EKSTROM RCT (n=84), low-dose colchicine (0.5 mg/day) did not significantly reduce low attenuation plaque volume (median change 0.1 vs…
A cheap anti-inflammatory drug called colchicine may help slow total plaque buildup in arteries for people already managing stable heart dis…
Research across Myocardial ischemia
Related studies from across the Myocardial ischemia family.
Novel pharmacotherapies like resmetirom and GLP-1 receptor agonists offer potential concurrent hepatic and cardiovascular benefits
New Medications Show Potential to Treat Liver and Heart Disease
This systematic review examines the epidemiological links and shared pathophysiological mechanisms between metabolic dysfunction-associated …
Newer drugs like resmetirom and GLP-1 receptor agonists may offer dual benefits for patients with both liver and heart conditions.
Staged PCI reduces severe kidney injury risk after TAVR in aortic stenosis and CAD
Staged heart procedures may lower risk of severe kidney injury
This meta-analysis of 7,119 patients with aortic stenosis and coronary artery disease undergoing TAVR found that staged PCI did not signific…
A new look at heart surgery data suggests that spacing out certain procedures could protect kidneys from severe damage.
SK-121 digital health program improves disease knowledge and medication adherence after PCI
Digital health program improves knowledge and blood pressure for heart patients
This single-centre RCT of 200 patients found that the SK-121 multimodal digital health program did not significantly reduce the SMART2 risk …
A digital health program helped heart patients improve their medical knowledge, medication habits, and blood pressure after a procedure.
Extended DAPT with clopidogrel and aspirin reduces cardiovascular death, myocardial infarction, and stroke risk
Extended dual antiplatelet therapy lowers risks for heart disease patients
This randomized trial of 8250 patients with multivessel coronary artery disease found that extending dual antiplatelet therapy (DAPT) for an…
Patients with coronary artery disease may have lower risks of stroke and heart attack when taking two blood thinners for an extra year.
Comparative Efficacy and Safety of Drug Coated Balloons Versus Drug Eluting Stents
Drug-coated balloons show lower bleeding rates than stents
A meta-analysis reveals that drug-coated balloons offer comparable clinical outcomes to drug-eluting stents while significantly reducing maj…
A large review of heart procedures shows drug-coated balloons offer a viable alternative to stents with fewer major bleeding risks for patie…
Postoperative educational interventions significantly reduce anxiety and depression in patients following coronary artery bypass grafting
Educational programs help patients after heart bypass surgery
This meta-analysis of 1,669 patients found that postoperative educational interventions significantly reduced anxiety (SMD = -0.48) and depr…
New research shows that educational programs can lower anxiety and depression for patients recovering from coronary artery bypass grafting.
21% hypertension prevalence in transgender adults: meta-analysis of cardiovascular morbidities
Transgender adults face high rates of heart disease
This meta-analysis of observational studies reports pooled prevalence of major cardiovascular morbidities among transgender adults aged ≥18 …
One in five transgender adults has high blood pressure, and many have heart disease, a new analysis finds.
Intravascular lithotripsy reduces mortality risk and MACE in calcified coronary lesions compared to rotational atherectomy
Intravascular lithotripsy shows better safety for calcified heart lesions
This meta-analysis of 1247 patients with calcified coronary lesions found that intravascular lithotripsy (IVL) significantly reduced mortali…
A new analysis suggests that using sound waves to break up hard calcium in arteries may lower risks like stroke and heart attack.
Patients with cardiovascular diseases show measurable prevalence of active cancer across multiple conditions
Heart disease patients show measurable risk of developing various cancers
This systematic review and meta-analysis analyzed 4,759,695 patients to determine the prevalence of active cancer in individuals with variou…
New data shows that people with heart conditions like stroke or heart failure have a measurable rate of active cancer cases.
Genetic Polymorphisms of SIRT1 Gene and Susceptibility to Coronary Artery Disease
Specific SIRT1 Gene Variations Linked to Coronary Artery Disease Risk
Meta-analysis identifies specific SIRT1 gene polymorphisms associated with increased coronary artery disease risk under distinct genetic mod…
New research identifies specific SIRT1 gene variations that may increase the risk of developing coronary artery disease.
Health literacy is moderately associated with improved self-care behaviors in patients with multiple chronic diseases
Better health literacy helps people manage chronic diseases more effectively
This meta-analysis of 138 studies found a moderate positive association (r = 0.29, 95% CI: 0.26-0.31) between health literacy and self-care …
Understanding medical information and using digital tools can help people with chronic conditions like diabetes or heart failure manage thei…
Off-pump CABG reduces mortality risk and stroke risk in patients with left ventricular dysfunction
Off-pump heart surgery shows lower death risk for weak hearts
This meta-analysis of 35,863 patients with multivessel coronary artery disease and left ventricular dysfunction (ejection fraction ≤40%) fou…
A large review of over 35,000 patients suggests off-pump heart surgery may reduce mortality and stroke risks for those with weakened heart m…
Questions about Coronary Atherosclerosis
How do combined lipid and anti-inflammatory therapies work for coronary atherosclerosis?
Combined therapies work by lowering LDL cholesterol while simultaneously reducing the chronic inflammation that drives plaque growth and rupture.
Full answer →What is the practical framework for treating coronary atherosclerosis?
Treating coronary atherosclerosis now requires a dual-axis framework that lowers lipids and targets inflammation, moving beyond just fixing blocked arteries to stabilizing the plaque itself.
Full answer →Can colchicine help reduce plaque in coronary atherosclerosis?
Yes, colchicine can help reduce plaque in coronary atherosclerosis by lowering inflammation, though evidence on direct plaque volume reduction is mixed.
Full answer →How does systemic lupus erythematosus affect coronary atherosclerosis?
Systemic lupus erythematosus causes premature coronary atherosclerosis through chronic inflammation, dysfunctional lipoproteins, and specific immune pathways that accelerate plaque buildup beyond traditional risk factors.
Full answer →