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Drug Pipeline
Meta-analysis
Seladelpar 10 mg shows optimal risk-benefit profile for UDCA-refractory primary biliary cholangitis patients
New data identifies promising treatments for primary biliary cholangitis
This network meta-analysis of 1,540 patients evaluates various therapies for primary biliary cholangitis (PBC) with inadequate response to U…
New research identifies specific medications that may improve liver health and relieve itching for patients with primary biliary cholangitis…
Frontiers
Sep 13, 2026
Gastroenterology
Meta-analysis
PPAR Agonists Reduce Pruritus in PBC: Meta-Analysis of 660 Patients
New drugs ease itch for patients whose current treatment fails
This systematic review and meta-analysis of 660 patients with primary biliary cholangitis and inadequate response to UDCA found that PPAR ag…
A review of six hundred sixty patients found new medicines significantly reduced itch scores in people with primary biliary cholangitis who …
May 1, 2026
Gastroenterology
RCT
Seladelpar shows improved composite endpoint and ALP reduction in PBC with compensated cirrhosis
New Drug Helps Liver Disease Patients With Cirrhosis
A phase 3 RCT program (RESPONSE and ASSURE studies) in patients with primary biliary cholangitis and compensated cirrhosis found seladelpar …
A new drug lowers liver stress markers in patients with cirrhosis, offering hope where older medicines often failed to stop disease progress…
Apr 14, 2026