Zibotentan plus dapagliflozin shows no HVPG reduction in compensated cirrhosis
Early trial shows zibotentan plus dapagliflozin trended toward lowering blood pressure in cirrhosis patients
This Phase II randomized placebo-controlled exploratory study in 28 patients with compensated cirrhosis found that zibotentan 2.5 mg plus da…
An early study found that a combination drug lowered blood pressure in patients with compensated cirrhosis, though it did not conclusively i…
Influenza vaccine induces stronger immune responses in liver cirrhosis patients
Flu Shot Works Better in Advanced Liver Disease
This prospective observational study found that patients with liver cirrhosis mount stronger humoral and cell-mediated immune responses to t…
You’re living with cirrhosis. Every cold feels dangerous.
Seladelpar shows improved composite endpoint and ALP reduction in PBC with compensated cirrhosis
New Drug Helps Liver Disease Patients With Cirrhosis
A phase 3 RCT program (RESPONSE and ASSURE studies) in patients with primary biliary cholangitis and compensated cirrhosis found seladelpar …
A new drug lowers liver stress markers in patients with cirrhosis, offering hope where older medicines often failed to stop disease progress…
Research across Cirrhosis
Related studies from across the Cirrhosis family.
Surgical resection plus postoperative TACE yields recurrence-free status in rare primary clear cell liver carcinoma
Rare Liver Cancer Case Treated With Surgery and TACE
This is a case report and literature review describing a 74-year-old woman with hepatitis B-related cirrhosis and primary clear cell carcino…
A 74-year-old woman with a rare liver cancer stayed cancer-free for years after surgery plus targeted chemotherapy delivered into the liver.
Refractory ascites significantly reduces social, mental, and physical functioning in patients with advanced chronic liver disease
Refractory ascites significantly lowers quality of life for liver patients
This systematic review and meta-analysis of 1040 patients with refractory ascites found significantly lower scores in social functioning (-1…
Living with fluid buildup from advanced liver disease causes significant drops in physical, mental, and social health for both patients and …
TIPS combined with embolization reduces rebleeding risk in patients with decompensated liver cirrhosis
TIPS Combined With Embolization Reduces Rebleeding in Liver Cirrhosis
This meta-analysis of 3079 patients with decompensated liver cirrhosis and variceal bleeding found that TIPS combined with embolization sign…
Adding embolization to TIPS procedures may lower rebleeding rates and the risk of liver-related complications for patients with severe liver…
Coagulopathy and hemodialysis significantly increase odds of post-ERCP bleeding in patients with cirrhosis
Risk factors for bleeding during and after ERCP procedures identified
This meta-analysis of 149,870 patients identified several risk factors for post-ERCP bleeding. Significant associations were found for coagu…
Identifying specific risk factors like cirrhosis and blood-thinning medications helps doctors better manage bleeding risks during ERCP proce…
Statins reduce overall mortality and hepatic venous pressure gradient in patients with liver cirrhosis
Statins may lower death rates for people with liver cirrhosis
This meta-analysis of patients with liver cirrhosis indicates that statin use is associated with a significantly decreased overall mortality…
New data suggests that statins can lower death rates and certain complications for people living with liver cirrhosis.
Hepatic macrophage metabolic reprogramming and bidirectional signaling dictate the balance between liver injury and regeneration
New research identifies how liver cells communicate during chronic disease
This systematic review synthesizes the role of hepatic macrophages in metabolic dysfunction-associated steatotic liver disease, alcohol-asso…
New research reveals how specific immune cells in the liver switch between causing inflammation and repairing tissue damage.
Prolonged SEMS retention for refractory variceal bleeding allows removal after 387 days
Doctors successfully remove a metal stent after one year of use
This case report describes a 72-year-old woman with decompensated cirrhosis who received a fully covered self-expanding metal stent (SEMS) f…
A new case report shows a metal stent can be safely removed after a year of use, offering a possible path for patients with liver disease.
Phase 2 Trial Evaluating Zalfermin and Semaglutide Combinations for Metabolic Dysfunction Associated Steatohepatitis
Trial Shows Semaglutide May Impact Liver Fibrosis in MASLD
A 52-week trial assessed whether zalfermin combined with semaglutide improves liver fibrosis in patients with advanced steatohepatitis.
A new trial suggests semaglutide may improve liver fibrosis in patients with MASLD, while other combinations did not show significant result…
Multidrug-resistant pathogens are prevalent in cirrhosis with higher rates in lower-middle-income countries
Gram-negative Bacteria and Resistance Patterns in Cirrhosis Patients
This systematic review and proportional meta-analysis of 2781 clinical infections and 381 colonizations in adults with cirrhosis identifies …
A large review of infections in patients with cirrhosis shows that 60% of bacterial isolates are Gram-negative and many show drug resistance…
Non-selective beta-blockers reduce mortality risk by 25% in patients with decompensated cirrhosis
Beta Blockers May Reduce Mortality Risk in Cirrhosis Patients
This meta-analysis of observational studies involving 120,072 patients found that non-selective beta-blockers (NSBBs) are associated with a …
A large-scale review suggests that non-selective beta-blockers may lower mortality risks for patients with decompensated cirrhosis, especial…
Sarcopenia Assessment Modalities and Mortality Risk Prediction in Patients with Liver Cirrhosis
Muscle Loss Linked to Higher Mortality Risk in Liver Cirrhosis
Meta-analysis confirms that sarcopenia significantly increases mortality risk in liver cirrhosis patients across multiple imaging and physic…
Patients with liver cirrhosis and muscle loss, known as sarcopenia, face a significantly higher risk of mortality across several different m…
Multidisciplinary teams and bloodless medicine pathways may improve outcomes for acute gastrointestinal bleeding
New research looks at better ways to treat internal bleeding
This systematic review synthesizes evidence on organizational models, such as multidisciplinary team programs and transfusion-free pathways,…
Specialized team-based care and bloodless medicine pathways show promise for patients with serious gastrointestinal bleeding.