Zibotentan plus dapagliflozin shows no HVPG reduction in compensated cirrhosis
Early trial shows zibotentan plus dapagliflozin trended toward lowering blood pressure in cirrhosis patients
This Phase II randomized placebo-controlled exploratory study in 28 patients with compensated cirrhosis found that zibotentan 2.5 mg plus da…
An early study found that a combination drug lowered blood pressure in patients with compensated cirrhosis, though it did not conclusively i…
Influenza vaccine induces stronger immune responses in liver cirrhosis patients
Flu Shot Works Better in Advanced Liver Disease
This prospective observational study found that patients with liver cirrhosis mount stronger humoral and cell-mediated immune responses to t…
You’re living with cirrhosis. Every cold feels dangerous.
Seladelpar shows improved composite endpoint and ALP reduction in PBC with compensated cirrhosis
New Drug Helps Liver Disease Patients With Cirrhosis
A phase 3 RCT program (RESPONSE and ASSURE studies) in patients with primary biliary cholangitis and compensated cirrhosis found seladelpar …
A new drug lowers liver stress markers in patients with cirrhosis, offering hope where older medicines often failed to stop disease progress…
Research across Cirrhosis
Related studies from across the Cirrhosis family.
Hepatologist-led palliative care matches specialist care for cirrhosis and cancer patients
Trained liver doctors provided care that matched specialists for patients with serious liver disease
A US trial found hepatologist-delivered palliative care noninferior to specialist care for improving quality of life in advanced liver disea…
Patients with advanced liver disease saw similar quality of life improvements when cared for by trained liver doctors versus specialists. Bo…
Endovascular interventions reduce rebleeding risk versus endoscopic cyanoacrylate injection in gastric variceal hemorrhage
Endovascular procedures reduce rebleeding risk for cirrhosis patients compared to injection therapy
This individual patient data meta-analysis compares endovascular interventions with endoscopic cyanoacrylate injection for gastric variceal …
A meta-analysis of 1,240 patients found endovascular procedures significantly lower rebleeding rates than injection therapy, though they car…
Antimicrobial resistance reaches 33.3% in cirrhosis patients with bacterial infections across global settings
Antimicrobial resistance is rising in cirrhosis patients worldwide
This systematic review and meta-analysis examines bacterial infections in 35,180 adult patients with cirrhosis globally. The analysis report…
A global analysis of 35,180 patients with cirrhosis shows rising antimicrobial resistance and varying mortality risks.
Review of antiviral and immunotherapeutic strategies for chronic hepatitis B
New antiviral strategies show promise for chronic hepatitis B infection
This narrative review synthesizes evidence on antiviral and immunotherapeutic strategies for chronic hepatitis B. The authors highlight func…
A review of new treatments suggests combination therapies may offer future value for managing chronic hepatitis B, cirrhosis, and liver canc…
Patient Buddy App reduced avoidable readmissions in cirrhosis inpatients compared to standard of care
App helps cirrhosis patients avoid hospital readmission
This randomized clinical trial enrolled 464 subjects (232 dyads) with cirrhosis in a multicenter setting.
A smartphone app cut avoidable hospital readmissions in half for cirrhosis patients, a new trial shows.
Five ACLF diagnostic models and prognostic scores identified markedly different proportions of patients at risk of 28-day mortality in a cohort study
Two new models find the sickest liver patients faster than old tools
This cohort study evaluated five acute-on-chronic liver failure (ACLF) diagnostic models and prognostic scores in 3,370 patients from the CO…
Two new scoring systems find the most dangerous liver failure patients better than older tools, potentially saving lives by catching risk ea…
Systematic review shows high rates of fibrosis and cirrhosis in children with Pi*ZZ alpha-1 antitrypsin deficiency
1 in 4 children with A1AT deficiency develop cirrhosis
This systematic review and meta-analysis examined children with confirmed Pi*ZZ alpha-1 antitrypsin deficiency to assess liver outcomes.
New analysis finds 41% of children with A1AT deficiency have liver fibrosis and 17% have cirrhosis.
Systematic review finds weak link between atypical antipsychotics and MASLD in youth
Atypical antipsychotics show a small link to liver disease in young patients
This systematic review and meta-analysis of 3 studies examined the association between atypical antipsychotics and metabolic dysfunction-ass…
A review of three studies found a small link between atypical antipsychotics and liver disease in children, but the evidence is limited.
L-taurine shows no overall fatigue benefit in decompensated cirrhosis but may help non-anemic patients
Taurine for cirrhosis fatigue fails overall but helps one group
This randomized controlled trial in 220 adults with decompensated cirrhosis found no significant difference in fatigue scores with L-taurine…
Taurine did not reduce fatigue in most cirrhosis patients, but those without anemia saw meaningful improvement, suggesting a targeted approa…
Systematic review links periodontitis to NAFLD progression and HCC risk
Your Mouth Could Be Harming Your Liver—Here’s What to Do
This systematic review finds that periodontitis and oral pathogens like F.
You brush your teeth every day. You might floss sometimes.
Integrative review of Epimedium flavonoids in hepatitis and cirrhosis shows preclinical promise but lacks clinical validation
Ancient Herb Shows New Promise for Liver Scarring and Hepatitis
This integrative review synthesizes data from 33 high-impact studies regarding Epimedium species and its bioactive flavonoids, icariin and i…
This research suggests a traditional herb may offer a new way to protect the liver, but more work is needed to prove it’s safe and effective…
Systematic review and meta-analysis on depression and anxiety prevalence in liver cirrhosis
More Than Half of Cirrhosis Patients Face Anxiety, New Global Study Reveals
This meta-analysis synthesized data from 23 studies including 979,113 patients with liver cirrhosis to estimate the prevalence of depression…
This massive global review proves that mental health struggles are a hidden, widespread crisis for people living with liver disease.