Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Medications › simvastatin

simvastatin

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of simvastatin

73 trials tracked of simvastatin: 33 in phase 3 or 4 and 7 with published results. The most-cited published study has 129 citations.

73Trials tracked
33Phase 3 & 4
0Recruiting
7With published results
Phase distribution
Phase 4 11 Phase 3 22 Phase 2 20 Phase 1 12 Other / NA 8
  1. Phase 4 Nephropathy In Type 2 Diabetes and Cardio-renal Events Completed · 129 cited
  2. Phase 3 Statin Therapy in the Treatment of Sepsis Completed · 62 cited
  3. Phase 3 Evaluation of Alirocumab Versus Ezetimibe on Top of Statin in Asia in High Cardiovascular Risk Patients With Hypercholesterolemia Completed · 49 cited
  4. Phase 3 An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial Hypercholesterolemia Completed · 39 cited
  5. Phase 3 An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia Completed · 31 cited
  6. Phase 4 Fixed Dose Intervention Trial of New England Enhancing Survival in SMI Patients Completed · 2 cited
Show 44 more trials
  1. Phase 3 Safety, Tolerability, and Effect of Alirocumab in High Cardiovascular Risk Patients With Severe Hypercholesterolemia Not Adequately Controlled With Conventional Lipid-modifying Therapies (ODYSSEY APPRISE) Completed · 2 cited
  2. Phase 4 Assessing the Role of "Statin" Therapy and Perioperative Inflammatory Response in Patients Undergoing Major Orthopedic Surgery Completed
  3. Phase 4 Effects of Simvastatin on Biomarkers Completed
  4. Phase 4 Simvastatin for mTBI Completed
  5. Phase 4 Effects of Ezetimibe, Simvastatin, and Vytorin on Reducing L5 a Subfraction of LDL in Patients With Metabolic Syndrome. Completed
  6. Phase 4 Comparison of Optimal Antipsychotic Treatments for Adults With Schizophrenia Completed
  7. Phase 4 The Effect of XueZhiKang on Fatigue：Comparing With Simvastatin Completed
  8. Phase 4 Simvastatin With or Without Ezetimibe and Atherothrombotic Biomarker Assessment Completed
  9. Phase 4 Comparison of the Effect of Vytorin 10/80 Tablet Split Into 4 and Simvastatin 20 Milligrams on Low-density Lipoprotein (LDL) Cholesterol Completed
  10. Phase 4 The PostprAndial eNdothelial Function After Combination of Ezetimibe and simvAstatin Study Completed
  11. Phase 3 Effect of Vitamin D Supplementation on Exercise Adaptations in Patients on Statin Therapy Completed
  12. Phase 3 Treatment of HDL to Reduce the Incidence of Vascular Events HPS2-THRIVE Completed
  13. Phase 3 Coadministration of Ezetimibe and Simvastatin in Patients With Primary Hypercholesterolemia (P05457) Completed
  14. Phase 3 Efficacy and Safety Study of MCI-196 Versus Simvastatin for Dyslipidaemia in Chronic Kidney Disease (CKD) Subjects on Dialysis Completed
  15. Phase 3 Evaluating How the Treatments in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study Affect Diabetic Retinopathy (The ACCORD Eye Study) Completed
  16. Phase 3 Follow-on Protocol of Pitavastatin Versus Simvastatin in Patients With Hypercholesterolemia or Dyslipidemia and Coronary Heart Disease Risk Factors Completed
  17. Phase 3 12-week Open-label, Phase IIIb Comparing Efficacy and Safety of Rosuvastatin (CRESTOR™) in Combination With Ezetimibe Completed
  18. Phase 3 Lipid Efficacy and Safety in Participants With Mixed Hyperlipidemia (MK-0524B-024) Completed
  19. Phase 3 Study to Compare the Efficacy and Safety of Pitavastatin and Simvastatin Completed
  20. Phase 3 Study to Compare the Efficacy and Safety of Pitavastatin and Simvastatin Completed
  21. Phase 3 LDL-C Assessment With PCSK9 Monoclonal Antibody Inhibition Combined With Statin Therapy-2 Completed
  22. Phase 3 IMPROVE-IT: Examining Outcomes in Subjects With Acute Coronary Syndrome: Vytorin (Ezetimibe/Simvastatin) vs Simvastatin (P04103) Completed
  23. Phase 3 A Year 2, Safety Extension Study of the Combination of ABT-335 and Statin Therapy for Subjects With Mixed Dyslipidemia Completed
  24. Phase 3 Effects of Ezetimibe With Simvastatin in the Therapy of Adolescents With HeFH (Study P02579) Completed
  25. Phase 3 Safety and Efficacy Study Comparing ABT-143 to Simvastatin in Subjects With Elevated Levels of Low Density Lipoprotein Cholesterol ("Bad Cholesterol") and Triglycerides Completed
  26. Phase 3 Evaluate Safety and Efficacy of ABT-335 in Combination With Simvastatin in Subjects With Multiple Abnormal Lipid Levels in the Blood Completed
  27. Phase 3 A Study for Pre-diabetic Patients With Cholesterol Lowering Drugs Completed
  28. Phase 2 Endothelial Facilitation in Alzheimer's Disease Completed
  29. Phase 2 Evaluating Simvastatin's Potential Role in Therapy Completed
  30. Phase 2 Simvastatin in Reducing Pancreatitis in Patients With Recurrent, Acute or Chronic Pancreatitis Completed
  31. Phase 2 Statin Effects on Beta-Amyloid and Cerebral Perfusion in Adults at Risk for Alzheimer's Disease Completed
  32. Phase 2 Effect of Simvastatin Treatment on Vaso-occlusive Pain in Sickle Cell Disease Completed
  33. Phase 2 Simvastatin in Preventing a New Breast Cancer in Women at High Risk for a New Breast Cancer Completed
  34. Phase 2 Pharmacokinetic Drug Interactions of AEGR-733 on Lipid-lowering Agents Completed
  35. Phase 2 Safety of Simvastatin in LAM and TSC Completed
  36. Phase 2 Simvastatin (Zocor) Therapy in Sickle Cell Disease Completed
  37. Phase 2 Simvastatin and Anastrozole in Treating Postmenopausal Women With Ductal Carcinoma In Situ or Invasive Breast Cancer Completed
  38. Phase 2 Clinical Trial of Zocor (Simvastatin) and Vytorin (Ezetimibe/Simvastatin) in Adolescents With Type 1 Diabetes Completed
  39. Phase 2 Investigation of Simvastatin in Secondary Progressive Multiple Sclerosis Completed
  40. Phase 2 Simvastatin in Secondary Progressive Multiple Sclerosis Completed
  41. Phase 2 Use of Topical Subgingival Application of Simvastatin Gel in the Treatment of Peri-Implant Mucositis Completed
  42. Phase 2 Statin/Vitamin D & Migraine Study Completed
  43. Phase 2 The Effect of Simvastatin on Breast Cancer Cell Growth in Women With Stage I-II Breast Cancer Completed
  44. Phase 2 Clinical Trial of Simvastatin to Treat Generalized Vitiligo Completed

Showing the 50 most-cited and recently-updated of 73 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Cerivastatin best for total cholesterol, simvastatin for LDL-C in DKD with hyperlipidemia
Diabetes & Endocrinology Meta-analysis
Cerivastatin best for total cholesterol, simvastatin for LDL-C in DKD with hyperlipidemia Lipid-Lowering Drugs Show Different Benefits for Kidney Disease
A network meta-analysis of 20 RCTs in patients with diabetic kidney disease and hyperlipidemia found that cerivastatin most effectively redu…
A review of 20 trials found that different statins and fenofibrate have unique effects on cholesterol, kidney markers, and heart risks in di…
Frontiers May 29, 2026
Proof of concept study uses preSCRIPT framework to annotate prescriptions in UK Biobank
Genetics & Precision Medicine
Proof of concept study uses preSCRIPT framework to annotate prescriptions in UK Biobank preSCRIPT framework identifies genetic links to drug response in UK Biobank
This proof of concept study utilized the preSCRIPT framework to filter and annotate raw prescription data from the UK Biobank, which include…
A proof of concept study in the UK Biobank used preSCRIPT to find genetic links to how people respond to common medications like warfarin an…
medRxiv Apr 30, 2026