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Neurology
RCT
Intravenous tirofiban before endovascular treatment increases risk of parenchymal hematoma type 2
Trial shows tirofiban increases bleeding risk in some stroke patients
This randomized controlled trial of 945 patients with acute large vessel occlusion of the anterior circulation found that intravenous tirofi…
A large trial found that using tirofiban before certain stroke treatments may increase the risk of specific types of brain bleeding.
Sep 2, 2026
Neurology
RCT
Tirofiban reduces median infarct volume from 88.2 mm to 48.6 mm in intracranial aneurysms
Trial shows tirofiban reduces brain tissue damage during aneurysm surgery
This Phase 2 randomized trial of 191 adults with unruptured intracranial aneurysms found that intravenous tirofiban combined with dual antip…
A new clinical trial suggests that adding the medication tirofiban can reduce the size of brain tissue damage for patients undergoing aneury…
Aug 9, 2026
Neurology
Meta-analysis
Tirofiban as an adjunct to endovascular thrombectomy is safe and effective for large vessel occlusion
Tirofiban May Improve Outcomes for Large Vessel Occlusion Stroke
This meta-analysis of 30 studies, including 2 RCTs and 28 cohort studies, evaluates tirofiban as an adjunct to endovascular thrombectomy in …
Adding tirofiban to stroke treatments may improve functional recovery and lower mortality risks for patients with large vessel occlusions.
Aug 1, 2026
Neurology
RCT
Early tirofiban improves functional outcomes in non-DM ischemic stroke patients but not in DM
Trial shows stroke treatment effects vary for patients with diabetes
This post-hoc analysis of a randomized controlled trial involving 832 patients with acute ischaemic noncardioembolic stroke found that early…
A new look at trial data suggests a common stroke medication works better for some patients than others based on their diabetes status.
Jul 14, 2026
Neurology
RCT
Tirofiban Adjunct Therapy Improves Outcomes in Patients with Inadequate Tenecteplase Response
Trial shows tirofiban improves outcomes for some stroke patients
Intravenous tirofiban significantly improves 90-day functional outcomes for acute ischemic stroke patients failing initial tenecteplase ther…
A new clinical trial suggests that adding tirofiban can improve recovery rates for certain types of stroke patients who do not respond well …
JAMA
Jun 13, 2026
Neurology
Meta-analysis
Meta-analysis shows tirofiban improves functional independence but raises intracranial hemorrhage risk in acute ischemic stroke patients
Tirofiban improves stroke recovery but raises bleeding risk
A meta-analysis of 4,210 patients found tirofiban increased functional independence at 90 days compared to conventional management. However,…
A review of 4210 patients finds tirofiban boosts functional independence after stroke but increases bleeding risk.
Jun 6, 2026
Neurology
Meta-analysis
Meta-analysis shows association between tirofiban and improved functional outcomes in non-LVO acute ischemic stroke
Tirofiban May Help More Stroke Patients Walk and Talk After 90 Days
This meta-analysis of 3,225 patients evaluated the association between tirofiban and conventional antiplatelet therapy for acute ischemic st…
A stroke drug called tirofiban may help more people recover fully after 90 days, especially when used with standard clot-busting treatment.
Frontiers
May 5, 2026
Neurology
Cohort
Tirofiban plus aspirin associated with lower early neurological deterioration in branch atheromatous disease
Early tirofiban plus aspirin linked to fewer early neurological declines in branch atheromatous disease patients
A retrospective single-center cohort study in patients with acute branch atheromatous disease found early tirofiban plus aspirin was associa…
Early tirofiban plus aspirin reduced early neurological decline from 55.1% to 10.1% in branch atheromatous disease patients compared to stan…
Frontiers
Apr 9, 2026