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Home › Medications › zidovudine

zidovudine

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of zidovudine

14 trials tracked of zidovudine: 7 in phase 3 or 4 and 2 with published results. The most-cited published study has 1421 citations.

14Trials tracked
7Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 1 Phase 3 6 Phase 2 6 Other / NA 1
  1. Phase 3 Anti-HIV Drugs for Treating Infants Who Acquired HIV Infection at Birth Completed · 1,421 cited
  2. Phase 3 Protease Inhibitors to Reduce Malaria Morbidity in HIV-Infected Pregnant Women Completed · 51 cited
  3. Phase 4 Antiretroviral Therapy for Advanced HIV Disease in South Africa Completed
  4. Phase 3 Human Immunodeficiency Virus (HIV) Postexposure Prophylaxis (PEP) With Darunavir/Ritonavir (DRV/r) Completed
  5. Phase 3 Trial of Three Neonatal Antiretroviral Regimens for Prevention of Intrapartum HIV Transmission Completed
  6. Phase 3 Safety and Efficacy of Switching From Stavudine or Zidovudine to Tenofovir DF in HIV-1 Infected Children Completed
Show 8 more trials
  1. Phase 3 Study of Options for Second-Line Effective Combination Therapy (SELECT) Completed
  2. Phase 2 A Study to Evaluate the Pharmacokinetics, Safety, Tolerability, and Antiviral Activity of Rilpivirine (TMC278) in Human Immunodeficiency Virus Infected Adolescents and Children Aged Greater Than or Equal to 6 Years Completed
  3. Phase 2 Belinostat Therapy With Zidovudine for Adult T-Cell Leukemia-Lymphoma Completed
  4. Phase 2 Tocilizumab for KSHV-Associated Multicentric Castleman Disease Completed
  5. Phase 2 Antiviral Responses to NNRTI-Based vs. PI-Based ARV Therapy in HIV Infected Infants Who Have or Have Not Received Single Dose NVP for Prevention of Mother-to-Child Transmission of HIV Completed
  6. Phase 2 Reducing the Incidence of Nevirapine Resistance Mutations in Pregnant HIV Infected Women Who Receive Anti-HIV Drugs Prior to and After Giving Birth Completed
  7. Phase 2 A Study to Evaluate Antiviral Activity of Darunavir + Ritonavir in HIV-1 Infected Adolescents Completed
  8. N/A Determining the Effects of Observed and Self-Administered Drug Regimens in HIV Infected Adults Completed

Showing the 14 most-cited and recently-updated of 14 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
HIV-1 resistance patterns vary by prior regimen and geographic region in this substudy
Infectious Disease RCT
HIV-1 resistance patterns vary by prior regimen and geographic region in this substudy HIV drug resistance patterns vary by region and prior treatment history
This substudy examined HIV-1 drug resistance mutations in people failing first-line therapy across 14 countries.
HIV drug resistance varies by region and prior treatment. Subtype C dominates, but resistance to common drugs is high. This matters for choo…
May 1, 2026
Nevirapine plus lamivudine and zidovudine improved lymphocyte counts and reduced adverse effects versus efavirenz in HIV patients
Infectious Disease RCT
Nevirapine plus lamivudine and zidovudine improved lymphocyte counts and reduced adverse effects versus efavirenz in HIV patients New HIV drug combo showed fewer side effects and better immune markers in small trial
This randomized controlled trial enrolled 100 patients with HIV/AIDS in a hospital setting.
A new HIV drug combo boosted immune cells and caused fewer side effects than the standard alternative in a recent trial.
NEJM Apr 14, 2026