Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Medications › zonisamide

zonisamide

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of zonisamide

19 trials tracked of zonisamide: 13 in phase 3 or 4.

19Trials tracked
13Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 4 3 Phase 3 10 Phase 2 4 Other / NA 2
  1. Phase 4 Comparative Study of Zonisamide and Carbamazepine as an Initial Monotherapy: Efficacy and Safety Evaluation Completed
  2. Phase 4 Zonisamide vs. Placebo in the Treatment of Alcohol Dependence Completed
  3. Phase 4 Open-label, Multi-center Trial of Zonisamide as Adjunctive Therapy in Patients With Uncontrolled Partial Epilepsy Completed
  4. Phase 3 Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes Completed
  5. Phase 3 Zonisamide Treatment of Alcohol Use Disorder: an Evaluation of Efficacy and Mechanism of Action Completed
  6. Phase 3 Interdisciplinary Study of A Novel Anticonvulsant in Alcoholism Completed
Show 13 more trials
  1. Phase 3 A Study to Assess the Efficacy and Safety of Adjunctive Zonisamide in Paediatric Partial Onset Seizures (CATZ Extension Study) Completed
  2. Phase 3 A Double-blind Study to Compare the Efficacy and Safety of Zonisamide and Carbamazepine as Monotherapy, in Newly Diagnosed Partial Epilepsy Completed
  3. Phase 3 A Study for Evaluating the Efficacy and Safety of Zonisamide and Lamotrigine (Lamictal) for Subjects With Refractory Simple Partial, Complex Partial or Partial With Secondary Generalized Seizures Completed
  4. Phase 3 Efficacy and Safety of Adjunctive Zonisamide in Paediatric Partial Onset Seizures (CATZ Study) Completed
  5. Phase 3 Evaluating the Efficacy and Safety of Zonisamide in the Treatment of Partial Seizures Completed
  6. Phase 3 Assessing The Long-Term Safety And To Explore The Long-Term Efficacy Of Zonisamide As Monotherapy In Newly Diagnosed Partial Seizures Completed
  7. Phase 3 Assessment of Safety and Efficacy of Therapy for the Prevention of Weight Gain Associated With Olanzapine Completed
  8. Phase 2 Zonisamide Augmentation of Varenicline Treatment for Smoking Cessation Completed
  9. Phase 2 Effect of Zonisamide on Cocaine Reinforcement, Craving, and Relapse Completed
  10. Phase 2 Zonisamide in Addition to E-CPT-C for Veterans With PTSD and Comorbid Alcohol Dependence Completed
  11. Phase 2 The Effects of Zonisamide on Alcohol Dependence Completed
  12. N/A Zonisamide for Weight Reduction in Obese Adults Completed
  13. N/A Alcohol Self Administration Laboratory Completed

Showing the 19 most-cited and recently-updated of 19 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Safinamide 100 mg outperforms rasagiline 1 mg and zonisamide 25 mg for motor fluctuations
Neurology Sys. Review
Safinamide 100 mg outperforms rasagiline 1 mg and zonisamide 25 mg for motor fluctuations Safinamide beats rasagiline for Parkinson's motor symptoms
This network meta-analysis of randomized controlled trials evaluated various adjunct therapies for Asian Parkinson's disease patients with m…
For Asian Parkinson's patients, adding safinamide to levodopa reduces OFF-time more than rasagiline or zonisamide.
Jun 16, 2026
First case report links zonisamide to homicidal ideation in epilepsy patient
Psychiatry Sys. Review
First case report links zonisamide to homicidal ideation in epilepsy patient First case report links zonisamide to homicidal thoughts in an epilepsy patient
A case report and literature review describes a patient with epilepsy who developed homicidal ideation during zonisamide uptitration. Sympto…
A patient developed homicidal thoughts after taking zonisamide. This rare case highlights a serious psychiatric side effect of the drug that…
Frontiers Jun 1, 2026