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Exercise training promotes adult hippocampal neurogenesis by influencing the neurochemical environment and cell cycle dynamicsExercise training may help grow new neurons in the brain

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Key Takeaway
Note that exercise training promotes hippocampal neurogenesis by influencing neurochemical environments and cell cycle dynamics.

This narrative review explores the mechanisms by which physical exercise impacts adult hippocampal neurogenesis and related cellular processes. The scope includes conditions such as Alzheimer's disease, epilepsy, and traumatic brain injury. The authors synthesize evidence suggesting that exercise training promotes neurogenesis by influencing the neurochemical environment and the functional integration of newly generated neurons.

Furthermore, the review highlights how physical exercise regulates cell cycle dynamics to activate and promote the proliferation of neural stem cells in the dentate gyrus. This process facilitates the differentiation and lineage progression of neural progenitor cells. The findings suggest that these mechanisms may provide insights into developing therapeutic strategies for various neurological and psychiatric disorders.

Limitations are not reported, but it is noted that the review summarizes existing literature rather than primary study data. Clinical application remains preliminary as the evidence is presented in a review context.

How this fits prior evidence

This narrative review explores mechanisms of neurogenesis following exercise training. It addresses a gap in understanding how physical activity influences neural stem cell proliferation and differentiation, which may relate to conditions like epilepsy or traumatic brain injury. While this review does not directly address the glymphatic burden associated with longer epilepsy duration or the efficacy of ketogenic diet therapies for seizure reduction, it provides a different perspective on neuroprotective mechanisms.

When we think about brain health, we often focus on how to protect existing cells. However, research into adult hippocampal neurogenesis shows that our brains have a remarkable ability to create new neurons. This process is vital for memory and learning, especially in people facing challenges like Alzheimer's disease, epilepsy, or traumatic brain injuries.

Evidence suggests that regular exercise training can actively promote this growth. It works by changing the chemical environment of the brain and helping new neurons integrate properly into existing networks. Specifically, physical activity helps regulate the cell cycle to activate neural stem cells. These stem cells are the building blocks that eventually become functional neurons in the hippocampus.

While these findings offer promising insights into how we might treat neurological and psychiatric disorders, it is important to remember that this information comes from a review of existing research rather than a single new trial. Because the specific mechanisms are still being mapped out, these results provide a foundation for future therapies rather than an immediate clinical prescription.

What this means for you:
Exercise can promote the growth of new neurons and stem cells in the brain's memory centers.

Common questions

Can exercise actually grow new brain cells?

Yes, evidence shows that exercise training can promote adult hippocampal neurogenesis. This means it helps the brain create new neurons by improving the chemical environment and helping those new cells join the brain's network. This process is particularly relevant for conditions like Alzheimer's disease and traumatic brain injuries.

How does exercise affect stem cells in the brain?

Physical exercise helps regulate the cell cycle to activate neural stem cells. These are special cells that can multiply and develop into different types of cells. By promoting these stem cells, exercise helps the brain's ability to create new neurons in areas responsible for memory.

What conditions might benefit from this type of research?

Understanding how exercise promotes new neuron growth could lead to better ways to treat several neurological and psychiatric disorders. Specifically, the research highlights potential benefits for people living with Alzheimer's disease, epilepsy, and those who have suffered traumatic brain injuries.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedJun 2026
View Original Abstract ↓
Adult neurogenesis is predominantly restricted to two neurogenic regions in the mammalian brain: the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus (DG) within the hippocampus. The hippocampus serves as a critical brain structure involved in learning and memory processes, and the continuous generation of new neurons contributes to enhanced synaptic plasticity. Accumulating evidence has demonstrated that impaired hippocampal neurogenesis is closely associated with various neuropsychiatric disorders, including Alzheimer's disease, epilepsy, and traumatic brain injury. Although the precise molecular and cellular mechanisms underlying adult neurogenesis remain incompletely elucidated, extensive research over the past several decades has identified numerous endogenous, exogenous, and environmental factors that modulate this process. Notably, exercise training, as a key exogenous stimulus, has been shown to promote adult hippocampal neurogenesis by influencing the neurochemical environment and functional integration of newly generated neurons. This review aims to summarize the relationship between cell cycle dynamics and adult hippocampal neurogenesis, with a particular emphasis on how physical exercise regulates the cell cycle to activate and promote the proliferation of neural stem cells (NSCs) in the DG, thereby facilitating the differentiation and lineage progression of neural progenitor cells. A deeper understanding of the regulatory mechanisms by which exercise enhances adult hippocampal neurogenesis may provide novel insights into the development of therapeutic strategies for neurological and psychiatric disorders.
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