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One anastomosis gastric bypass provides durable weight loss and metabolic improvements over 15 yearsGastric Bypass Shows Durable Weight Loss and Health Improvements

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Key Takeaway
Note that OAGB provides durable weight loss and high resolution rates for comorbidities like hypertension and sleep apnea.

This meta-analysis evaluates the long-term clinical outcomes for patients undergoing one anastomosis gastric bypass (OAGB). The analysis includes data from 1729 patients to assess weight loss, metabolic improvements, and safety profiles over 10 and 15 year follow-up periods.

Key findings include a total weight loss of 31.80% at 10 years and 32.44% at 15 years. Significant reductions in body mass index were observed, recorded at 15.41 kg/m2 at 10 years and 13.87 kg/m2 at 15 years. Excess weight loss was reported at 75.87% at 10 years and 69.81% at 15 years. Metabolic improvements included a 72% resolution rate for type 2 diabetes, 66% for hypertension, 67% for dyslipidemia, and 86% for obstructive sleep apnea.

Safety data indicate a 6% incidence of de novo gastroesophageal reflux disease (GERD), with only 3% requiring revisional surgery. The authors note that data on the long-term effects of OAGB are scarce. Clinical application should consider these findings as evidence of durable weight loss and favorable metabolic outcomes, while noting the association is derived from retrospective studies.

How this fits prior evidence

This meta-analysis addresses a gap in long-term data for bariatric procedures. It provides evidence of durable weight loss and metabolic improvements, which may be relevant for patients with comorbidities like obstructive sleep apnea, which is noted in prior evidence to cause neurocognitive deficits in children. It also addresses outcomes for type 2 diabetes, a condition managed in other contexts by GLP-1 receptor agonists and SGLT2 inhibitors.

This analysis looked at the long-term effects of one anastomosis gastric bypass (OAGB) on 1,729 patients. The study followed patients for up to 15 years to see how the surgery affected weight and other health conditions like diabetes, high blood pressure, and sleep apnea.

Patients who had the surgery saw significant weight loss that lasted over a decade. Specifically, they saw a 31.80% weight loss at 10 years and a 32.44% loss at 15 years. The study also found that the surgery helped resolve many health issues, including a 72% resolution rate for type 2 diabetes and an 86% resolution rate for obstructive sleep apnea.

While the surgery showed positive results for weight and metabolism, some patients did develop acid reflux (GERD) after the procedure. However, only 3% required a second surgery for this issue. Because long-term data on this specific surgery is still limited, these results show a link between the surgery and better health, but you should talk to your doctor about how these findings apply to your specific health needs.

What this means for you:
Gastric bypass surgery is linked to lasting weight loss and improved conditions like diabetes and high blood pressure.

Common questions

How much weight is lost after gastric bypass surgery?

Patients who underwent the surgery showed a 31.80% total weight loss at 10 years and a 32.44% weight loss at 15 years. This represents a significant reduction in body mass index over a long period.

Can gastric bypass help with other health conditions?

The surgery was linked to the resolution of several conditions. These included a 72% resolution rate for type 2 diabetes, a 66% resolution rate for hypertension, and an 86% resolution rate for obstructive sleep apnea.

Are there any risks or side effects from the surgery?

Some patients developed gastroesophageal reflux disease (GERD) after the procedure, which occurred in 6% of cases. However, only 3% of patients required a follow-up surgery to treat this reflux issue.

Study Details

Study typeMeta analysis
Sample sizen = 1,729
EvidenceLevel 1
Follow-up120.0 mo
PublishedOct 2026
View Original Abstract ↓
BACKGROUND: Data on the long-term effects of one anastomosis gastric bypass (OAGB) are scarce. This systematic review and meta-analysis assessed the long-term outcomes of OAGB with a minimum of 10 years of follow-up. METHODS: A systematic search was conducted in Web of Science, Scopus, Embase, and PubMed. Two independent authors performed the selection and data extraction processes. RESULTS: Eight retrospective studies involving a total of 1729 patients met the inclusion criteria. OAGB was associated with a mean body mass index reduction of 15.41 kg/m² at 10 years and 13.87 kg/m² at 15 years. Total weight loss was 31.80% at 10 years and 32.44% at 15 years, whereas excess weight loss was 75.87% and 69.81%, respectively. The resolution rates of type 2 diabetes, hypertension, dyslipidemia, and obstructive sleep apnea were 72%, 66%, 67%, and 86%, respectively. The incidence of de novo gastroesophageal reflux disease (GERD) was 6%, and revisional surgery due to GERD occurred in 3% of patients. CONCLUSION: OAGB demonstrates durable weight loss, favorable metabolic outcomes, and acceptable long-term safety.
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