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Local or regional anaesthesia shows no significant difference in overall survival for breast cancer patientsLocal anesthesia does not change long term breast cancer survival

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Key Takeaway
Note that local or regional anaesthesia does not significantly impact overall survival in breast cancer patients.

This secondary analysis of a randomized controlled trial evaluated the impact of anesthesia types on outcomes in 1670 breast cancer patients. The study compared local anaesthetic infiltration or regional anaesthesia (paravertebral block) against no local or regional anaesthesia.

In the primary outcome of overall survival, no significant differences were observed between the pooled group receiving any local or regional anaesthesia (n=945) and those receiving neither (n=725) with a p-value of 0.54. Furthermore, when comparing all four groups—local infiltration, paravertebral block, both, or neither—no significant differences were observed among the 1670 total patients (p=0.89).

Safety and tolerability data were not reported in this analysis. A primary limitation of this study is that it was a non-preplanned secondary analysis. The findings indicate no association between local or regional anaesthetic use and long-term survival, suggesting these techniques may be selected based on clinical preference without impacting survival outcomes.

How this fits prior evidence

How this fits prior evidence: This finding addresses the impact of anesthetic interventions on breast cancer patient outcomes. While other covered items focus on diagnostic tools like cfDNA, lifestyle factors such as a healthy diet to decrease C-reactive protein levels, and surgical reconstruction techniques like autologous fat grafting, this study specifically examines the role of local/regional anesthesia in survival. It confirms that while these techniques are used for procedural comfort, they do not appear to influence long-term survival metrics.

When a patient faces breast cancer surgery, the focus is often on the immediate experience: managing pain and staying calm. Doctors sometimes use local anesthetic infiltration or regional blocks to numb specific areas. This study looked at whether these techniques changed long-term outcomes for patients.

The researchers analyzed data from 1,670 breast cancer patients over a period of more than six years. They compared those who received some form of local or regional anesthesia against those who did not. The results showed no significant difference in overall survival between the groups. Whether a patient received one type of numbing technique or none at all, the long-term survival rates remained similar.

It is important to note that this was a secondary analysis, meaning it was not the primary goal of the original trial. While the study provides clear data on survival, it does not provide specific details on patient comfort levels or immediate side effects. These findings suggest that while local anesthesia may help with surgical comfort, it does not change the long-term survival outlook for breast cancer patients.

What this means for you:
Using local or regional anesthesia during surgery does not impact long-term survival rates for breast cancer patients.

Common questions

Does using local anesthesia affect how long a breast cancer patient lives?

The study of 1,670 patients found no significant difference in overall survival for those who received local or regional anesthesia compared to those who did not. The results suggest that these numbing techniques do not impact the long-term survival outcomes for people with breast cancer.

What types of anesthesia were tested in this study?

The researchers looked at local anesthetic infiltration and regional anesthesia, specifically a paravertebral block. They compared these methods against receiving no local or regional anesthesia to see if they influenced survival rates.

How long were the patients followed in this study?

The study included a median follow-up of 76.8 months. This timeframe allowed researchers to look at the overall survival of the 1,670 patients over several years following their procedures.

Study Details

Study typeRct
EvidenceLevel 2
PublishedJul 2026
View Original Abstract ↓
INTRODUCTION: This study investigates long-term survival in the Cancer and Anaesthesia (CAN) study, focusing on the potential impact of local anaesthetic infiltration during breast cancer surgery. A positive effect from peritumoral infiltration has recently been suggested. We conducted an exploratory data analysis to examine a possible association between uncontrolled exposure to local anaesthetics during breast cancer surgery and long-term survival. METHODS: Breast cancer patients were recruited to compare long-term survival according to whether anaesthesia was maintained with inhaled sevoflurane or intravenous propofol. Other aspects of anaesthesia, such as the use of local- or regional anaesthesia, were carried out pragmatically according to local institutional guidelines. Kaplan-Meier survival curves were constructed to compare survival between those who received local anaesthetics or not. RESULTS: Among 1670 analysed patients, 803 (48.1%) received local anaesthetic infiltration, 67 (4.0%) received a paravertebral block, 75 (4.5%) received both, and 725 (43.4%) received neither. Over a median follow-up of 76.8 months, no significant differences in overall survival were observed - either between the pooled group of patients who received any local or regional anaesthesia (n = 945) and those who received neither (n = 725; p = 0.54), or among all four groups (p = 0.89). CONCLUSION: We found no association with local-anaesthetic skin infiltration or regional anaesthesia and long-term survival in this non-preplanned secondary analysis of a randomised controlled trial. EDITORIAL COMMENT: In this secondary analysis of an observational follow-up study for anaesthetic exposure and cancer outcomes, regional or localized local anaesthetic treatments were not associated with a survival advantage. How regional anaesthesia or local anaesthetics might interact with clinical cancer natural history in patients is still not clear, though the results here do not support a large effect. TRIAL REGISTRATION: EudraCT number: 2013-002380-25; ClinicalTrials.gov Identifier: NCT01975064.
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