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Home › Medications › sevoflurane

sevoflurane

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of sevoflurane

37 trials tracked of sevoflurane: 17 in phase 3 or 4 and 3 with published results. The most-cited published study has 55 citations.

37Trials tracked
17Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 13 Phase 3 4 Phase 2 4 Other / NA 16
  1. Phase 3 Sugammadex After Continuous Infusion of Rocuronium During Sevoflurane and Propofol Anesthesia (P05949; MK-8616-028) Completed · 55 cited
  2. Phase 4 Total Intravenous Anesthesia in Sinus Surgery Completed · 47 cited
  3. Phase 4 Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy Completed · 2 cited
  4. Phase 4 The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects Completed
  5. Phase 4 Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function Completed
  6. Phase 4 Sevoflurane as an Anesthetic During Dilation and Evacuation Procedures Completed
Show 31 more trials
  1. Phase 4 Effect of Deep Neuromuscular Block (NMB), Inhalation or TIVA on Pneumoperitoneum. Completed
  2. Phase 4 Dexmedetomidine and Propofol for Pediatric MRI Sedation Completed
  3. Phase 4 Opioid-Free Shoulder Arthroplasty Completed
  4. Phase 4 Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain Completed
  5. Phase 4 Comparison of Emergence Agitation Between Sevoflurane and Desflurane Anesthesia After Orthognathic Surgery Completed
  6. Phase 4 Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block Completed
  7. Phase 4 Propofol Versus Sevoflurane Recovery After Gynecological Surgery Completed
  8. Phase 4 Recovery Following Desflurane Versus Sevoflurane for Outpatient Urologic Surgery in Elderly Females Completed
  9. Phase 3 Xenon Compared to Sevoflurane and Total Intravenous Anaesthesia for Coronary Artery Bypass Graft Surgery Completed
  10. Phase 3 Cardiovascular Safety of Xenon in General Anaesthesia, in Patient With Cardiovascular Risk in Non Cardiac Surgery Completed
  11. Phase 3 Comparing Desflurane to Sevoflurane for the Effect on Recovery Time in Patients Undergoing Urological Cystoscope Surgery Completed
  12. Phase 2 Analgesic Effect of IV Acetaminophen in Tonsillectomies Completed
  13. Phase 2 Optimization of Desflurane in Elderly Patients Completed
  14. Phase 2 Anesthetics to Prevent Lung Injury in Cardiac Surgery Completed
  15. Phase 2 EEG Studies of Sevoflurane-Induced General Anesthesia Completed
  16. N/A The Effect of Preoperative Ketamine on the Emergence Characteristics in Children Undergoing Entropion Surgery Completed
  17. N/A Evaluation of Micropore"s SpiraLith Absorbents Completed
  18. N/A Anesthesia and Lymphocytes Apoptosis Completed
  19. N/A Comparison of Propofol and Sevoflurane as a Primary Anesthetic for Cardiac Ablation of Atrial Fibrillation. Completed
  20. N/A Decision Support for Intraoperative Low Blood Pressure Completed
  21. N/A Intraoperative Bleeding During Endoscopic Sinus Surgery Completed
  22. N/A Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia Completed
  23. N/A Pain After Laparoscopic Cholecystectomy Completed
  24. N/A Volatile Anesthetic Choice and Duration of Hospitalization: A Quality Improvement and Cost-control Project Completed
  25. N/A Emergence Agitation Between Dexmedetomidine and Sevoflurane Anesthesia Completed
  26. N/A Optimal Sevoflurane Concentration for Intubation in Combination of Clincal Remifentanil Doses Completed
  27. N/A Post Extubation Delirium and End-tidal Sevoflurane Concentration Completed
  28. N/A Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins Completed
  29. N/A Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis Completed
  30. N/A Propofol and Sevoflurane for Catheter-Related Bladder Discomfort Completed
  31. N/A Markers of Liver Apoptosis After Anesthesia With Sevoflurane or Propofol Completed

Showing the 37 most-cited and recently-updated of 37 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Awake laryngeal mask removal reduces airway obstruction risk compared to deep laryngeal mask removal
Pediatrics Meta-analysis
Awake laryngeal mask removal reduces airway obstruction risk compared to deep laryngeal mask removal Awake laryngeal mask removal shows lower airway obstruction risk in children
This meta-analysis of 1,713 pediatric patients in non-airway surgery found no significant difference in overall airway complications between…
Removing a breathing mask while a child is awake may reduce the risk of airway obstruction compared to removing it while they are deeply sed…
Aug 5, 2026
Local or regional anaesthesia shows no significant difference in overall survival for breast cancer patients
OB/GYN & Women's Health RCT
Local or regional anaesthesia shows no significant difference in overall survival for breast cancer patients Local anesthesia does not change long term breast cancer survival
This secondary analysis of a randomized controlled trial involving 1670 breast cancer patients found no significant differences in overall s…
A large study of over 1,600 patients found that using local or regional anesthesia during surgery did not affect overall survival rates.
Jul 2, 2026
Lignocaine-based opioid-free anesthesia increases sevoflurane need in head-and-neck cancer surgery
ENT (Otolaryngology) RCT
Lignocaine-based opioid-free anesthesia increases sevoflurane need in head-and-neck cancer surgery Opioid-free surgery needs more gas to keep patients asleep safely
This randomized trial in 30 patients undergoing head-and-neck cancer surgery found that lignocaine-based opioid-free anesthesia required hig…
Opioid-free anesthesia using lignocaine needs more breathing gas and causes more blood pressure spikes than morphine during major head surge…
May 1, 2026
Propofol and sevoflurane anesthesia show divergent EEG signatures in retrospective surgical patient analysis
Anesthesiology & Pain Medicine Cohort
Propofol and sevoflurane anesthesia show divergent EEG signatures in retrospective surgical patient analysis Two Common Anesthesia Drugs Show Different Brain Patterns
This retrospective analysis examined electroencephalogram signatures in 44 surgical patients receiving propofol or sevoflurane anesthesia.
A new brainwave model can tell propofol and sevoflurane apart, which could help anesthesiologists tailor sedation for safer, more precise ca…
Frontiers Apr 29, 2026
Pilot RCT assesses feasibility of comparing propofol vs. sevoflurane anesthesia for stroke thrombectomy
Neurology RCT
Pilot RCT assesses feasibility of comparing propofol vs. sevoflurane anesthesia for stroke thrombectomy Pilot study tests feasibility of comparing anesthesia types for stroke surgery
A pilot RCT enrolled 93 patients undergoing endovascular thrombectomy for acute ischemic stroke to assess the feasibility of comparing propo…
A pilot study testing two anesthesia types for stroke surgery found the research process worked well without showing differences in patient …
Apr 9, 2026