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Home › Medications › propofol

propofol

16 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of propofol

89 trials tracked of propofol: 49 in phase 3 or 4 and 12 with published results. The most-cited published study has 274 citations.

89Trials tracked
49Phase 3 & 4
0Recruiting
12With published results
Phase distribution
Phase 4 36 Phase 3 13 Phase 2 5 Phase 1 2 Other / NA 33
  1. Phase 3 The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure Completed · 274 cited
  2. Phase 4 The Effect of Different Sedation Regimes on Cognitive Function in Lower Gastrointestinal System Endoscopy Completed · 169 cited
  3. Phase 4 UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study Completed · 61 cited
  4. Phase 3 Sugammadex After Continuous Infusion of Rocuronium During Sevoflurane and Propofol Anesthesia (P05949; MK-8616-028) Completed · 54 cited
  5. Phase 4 Total Intravenous Anesthesia in Sinus Surgery Completed · 47 cited
  6. Phase 4 Propofol vs. Midazolam-based Balanced Propofol for Nonanesthesiologist Moderate Sedation in Colonoscopy Completed · 42 cited
Show 44 more trials
  1. Phase 4 Ketamine and Propofol for Upper Endoscopy Completed · 28 cited
  2. Phase 4 Cognitive Functions After TIVA With Dexmedetomidine Completed · 26 cited
  3. Phase 4 Comparison of Bolus Dosing of Methohexital and Propofol in Elective Direct Current Cardioversion Completed · 4 cited
  4. Phase 3 Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1) Completed · 4 cited
  5. Phase 3 Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2) Completed · 3 cited
  6. Phase 4 Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy Completed · 2 cited
  7. Phase 4 The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects Completed
  8. Phase 4 Propofol Versus Alfentanil Versus Nitrous Oxide for Moderate Procedural Sedation Completed
  9. Phase 4 Dexmedetomidine Versus Propofol in Vitreoretinal Surgery Completed
  10. Phase 4 Patient Satisfaction With Propofol for Out Patient Colonoscopy Completed
  11. Phase 4 The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI) Completed
  12. Phase 4 Moderate Versus Deep Procedural Sedation With Propofol in the Emergency Department Completed
  13. Phase 4 Propofol and Dexmedetomidine Versus a Propofol Only Regimen for Sedation During Colonoscopy Completed
  14. Phase 4 Propofol in Emergence Agitation Completed
  15. Phase 4 Dexmedetomidine and Propofol for Pediatric MRI Sedation Completed
  16. Phase 4 Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure Completed
  17. Phase 4 Neuroimaging of Anesthetic Modulation of Human Consciousness Completed
  18. Phase 4 Recovery Profile Comparison Between Remifentanil-propofol or Desflurane Anesthesia Monitored With Bispectral Index. Completed
  19. Phase 4 Opioid-Free Shoulder Arthroplasty Completed
  20. Phase 4 Propofol for Pediatric Tracheal Intubation With Deep Anesthesia During Sevoflurane Induction Completed
  21. Phase 4 Safety and Efficacy of Dexmedetomidine (DEX) for Sedation of Subjects ≥1 Month to <17 Years Undergoing MRI Scans Completed
  22. Phase 4 Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain Completed
  23. Phase 4 Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea Completed
  24. Phase 4 Desflurane or Propofol Anesthesia in Elderly Obese Patients Undergoing Total Knee Replacement Completed
  25. Phase 4 Efficacy of Propofol or Midazolam Compare to Placebo for Preoperative Medication Completed
  26. Phase 4 Propofol Administered by Gastroenterologists by Target Controlled Infusion Pump During Endoscopy Completed
  27. Phase 4 Propofol Versus Ketamine for Moderate Procedural Sedation in the Emergency Department (ED) Completed
  28. Phase 4 Dexmedetomidine vs Propofol TIVA (Total Intravenous Anesthesia) and Interscalene Block Completed
  29. Phase 4 Propofol Versus Sevoflurane Recovery After Gynecological Surgery Completed
  30. Phase 4 Regimen of Alfentanil in Propofol Sedative Fibro-bronchoscopy Completed
  31. Phase 4 Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine. Completed
  32. Phase 4 Stress During Deep Sedation With Propofol With and Without Alfentanil Completed
  33. Phase 4 Randomized Clinical Trial of Propofol, 1:1 and 4:1 Combination of Propofol and Ketamine for Procedural Sedation Completed
  34. Phase 4 Effects of General Anesthesia and Spinal-Morphine Anesthesia on Recovery and Comfort After Benign Abdominal Hysterectomy Completed
  35. Phase 3 Low-dose Propofol for Pediatric Migraine Completed
  36. Phase 3 Propofol in Obese Children Completed
  37. Phase 3 Evaluate Use of Caudal Nerve Blocks in Adult Penile Prosthesis Completed
  38. Phase 3 Efficacy and Safety of HSK3486 Compared to Propofol in Induction of General Anesthesia in Adults Having Elective Surgery Completed
  39. Phase 3 Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia Completed
  40. Phase 3 Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery Completed
  41. Phase 3 Use of a Modified Propofol Emulsion in Adults Completed
  42. Phase 3 Xenon Compared to Sevoflurane and Total Intravenous Anaesthesia for Coronary Artery Bypass Graft Surgery Completed
  43. Phase 3 Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery Completed
  44. Phase 2 Analgesic Effect of IV Acetaminophen in Tonsillectomies Completed

Showing the 50 most-cited and recently-updated of 89 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Meta-analysis of remimazolam versus propofol in mechanically ventilated ICU patients
Emergency Medicine Meta-analysis
Meta-analysis of remimazolam versus propofol in mechanically ventilated ICU patients New ICU Sedative Cuts Patient Side Effects Without Raising Risks
This meta-analysis of randomized controlled trials compared remimazolam to propofol in mechanically ventilated ICU patients. It found no sig…
A safer sedative option for ICU patients on ventilators reduces dangerous confusion and side effects while matching current treatments in su…
May 15, 2026
Propofol-first sequence reduces hypoxemia in obese patients undergoing gastroscopy
Diabetes & Endocrinology RCT
Propofol-first sequence reduces hypoxemia in obese patients undergoing gastroscopy Giving anesthesia in a new order cuts oxygen risk for obese patients
This single-center RCT compared propofol-first versus remifentanil-first sedation sequences in obese patients undergoing gastroscopy. The pr…
A new drug sequence cuts low oxygen events by nearly half in obese patients getting gastroscopy sedation.
May 2, 2026
Lignocaine-based opioid-free anesthesia increases sevoflurane need in head-and-neck cancer surgery
ENT (Otolaryngology) RCT
Lignocaine-based opioid-free anesthesia increases sevoflurane need in head-and-neck cancer surgery Opioid-free surgery needs more gas to keep patients asleep safely
This randomized trial in 30 patients undergoing head-and-neck cancer surgery found that lignocaine-based opioid-free anesthesia required hig…
Opioid-free anesthesia using lignocaine needs more breathing gas and causes more blood pressure spikes than morphine during major head surge…
May 1, 2026
Network meta-analysis of ketamine regimens for pediatric ED procedural sedation safety and efficacy
Pediatrics Meta-analysis
Network meta-analysis of ketamine regimens for pediatric ED procedural sedation safety and efficacy Ketamine combos ease pain in kids with less nausea
This network meta-analysis evaluated ketamine-based regimens versus IV ketamine for pediatric procedural sedation in the emergency departmen…
A new analysis reveals a ketamine-propofol mix calms injured children faster and with fewer side effects than ketamine alone.
Apr 29, 2026
Remimazolam reduces propofol requirement during gastroscopy in adults
Drug Pipeline Cohort
Remimazolam reduces propofol requirement during gastroscopy in adults Remimazolam may lower propofol needs for gastroscopy in healthy adults
This randomized double-blind trial in ASA I-II adults aged 18–59 years found that adding remimazolam to propofol sedation for gastroscopy re…
A trial found remimazolam reduced the amount of propofol needed for sedation during gastroscopy in healthy adults without increasing recover…
Frontiers Apr 29, 2026
Propofol and sevoflurane anesthesia show divergent EEG signatures in retrospective surgical patient analysis
Anesthesiology & Pain Medicine Cohort
Propofol and sevoflurane anesthesia show divergent EEG signatures in retrospective surgical patient analysis Two Common Anesthesia Drugs Show Different Brain Patterns
This retrospective analysis examined electroencephalogram signatures in 44 surgical patients receiving propofol or sevoflurane anesthesia.
A new brainwave model can tell propofol and sevoflurane apart, which could help anesthesiologists tailor sedation for safer, more precise ca…
Frontiers Apr 29, 2026
Remimazolam shows comparable sedation success and better hemodynamic stability versus propofol in fiberoptic bronchoscopy
Drug Pipeline Cohort
Remimazolam shows comparable sedation success and better hemodynamic stability versus propofol in fiberoptic bronchoscopy Remimazolam keeps breathing steadier during bronchoscopy than propofol
This retrospective analysis compared remimazolam and propofol in patients undergoing fiberoptic bronchoscopy with preserved spontaneous brea…
Remimazolam matched propofol’s success during bronchoscopy while cutting low oxygen, injection pain, and low blood pressure.
Frontiers Apr 25, 2026
Network meta-analysis of sedation strategies in therapeutic gastrointestinal endoscopy shows ketamine-propofol reduces hypoxia and bradycardia versus propofol-opioid
Drug Pipeline Meta-analysis
Network meta-analysis of sedation strategies in therapeutic gastrointestinal endoscopy shows ketamine-propofol reduces hypoxia and bradycardia versus propofol-opioid Better Sedation Choices Could Reduce Side Effects During Stomach Tests
This network meta-analysis evaluated pharmacological sedation strategies in 7,071 patients undergoing therapeutic gastrointestinal endoscopy…
Mixing ketamine with propofol lowers breathing and blood pressure risks for patients undergoing long stomach procedures compared to standard…
Frontiers Apr 21, 2026
Narrative review on remimazolam reversal with flumazenil versus propofol sedation
Rheumatology Meta-analysis
Narrative review on remimazolam reversal with flumazenil versus propofol sedation New Sedation Reversal Method Cuts Recovery Time by 4 Minutes
This narrative review synthesizes evidence on flumazenil reversal of remimazolam-induced sedation compared to propofol-based sedation.
A new sedation reversal method helps patients wake up four minutes faster after procedures while reducing breathing and blood pressure issue…
Frontiers Apr 20, 2026
Preoperative femoral nerve block reduces rebound pain after knee arthroplasty versus postoperative block
Rheumatology RCT
Preoperative femoral nerve block reduces rebound pain after knee arthroplasty versus postoperative block Give Nerve Block Before Surgery To Stop Pain
In an RCT of 186 patients undergoing total knee arthroplasty, preoperative femoral nerve block with ropivacaine reduced rebound pain inciden…
Getting a pain-numbing shot before knee surgery cuts rebound pain in half, helps patients sleep better, and reduces the need for strong pain…
Frontiers Apr 10, 2026
Pilot RCT assesses feasibility of comparing propofol vs. sevoflurane anesthesia for stroke thrombectomy
Neurology RCT
Pilot RCT assesses feasibility of comparing propofol vs. sevoflurane anesthesia for stroke thrombectomy Pilot study tests feasibility of comparing anesthesia types for stroke surgery
A pilot RCT enrolled 93 patients undergoing endovascular thrombectomy for acute ischemic stroke to assess the feasibility of comparing propo…
A pilot study testing two anesthesia types for stroke surgery found the research process worked well without showing differences in patient …
Apr 9, 2026
Regional anesthesia with propofol sedation versus general anesthesia in unilateral total knee arthroplasty patients
Rheumatology Cohort
Regional anesthesia with propofol sedation versus general anesthesia in unilateral total knee arthroplasty patients Numb Legs, Faster Walks: New Knee Surgery Data
This retrospective cohort study evaluated 250 patients undergoing unilateral total knee arthroplasty to compare regional anesthesia with mon…
New knee surgery data shows regional anesthesia leads to faster walking and fewer readmissions without increasing dangerous blood clot risk.
Frontiers Apr 9, 2026

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