This review looked at how people with obesity and type 2 diabetes respond to the medication semaglutide. The researchers found that several factors influence how much weight a person might lose. For example, women were found to lose more weight than men, and a higher maintenance dose of 7.2 mg showed better results than the standard 2.4 mg dose.
Other factors like age and starting body mass index did not show a clear link to weight loss. However, the study noted that people with a specific gut trait called a hungry gut phenotype might see more results. There was also a possibility that being younger or having a higher weight at the start could improve the treatment effect, though this is still being studied.
It is important to note that some of these findings, like the hungry gut trait, are based on preliminary data. Also, the way genes affect how people respond to the drug is not fully understood yet. These findings suggest that doctors may eventually use these markers to provide more personalized care for patients with obesity.
