This systematic review looked at how computational modelling derived from patient-specific imaging compares to standard computed tomography-based anatomical assessment for patients undergoing transcatheter aortic valve replacement. The analysis focused on secondary outcomes like paravalvular leak, conduction disturbances, coronary obstruction, and aortic injury. No primary outcome was reported in the review. The review noted that safety data, such as adverse events or discontinuations, were not reported in the included studies.
The study populations were small and used heterogeneous methodologies, which limits the strength of the findings. There was also limited patient-specific validation and a lack of integration into routine clinical workflows. These factors mean the results cannot yet be used to guide immediate patient care decisions.
Future progress will require validation against clinically meaningful endpoints, scalable digital infrastructure, and close collaboration between clinicians and engineers. Until these steps are taken, simulation outputs should not replace standard Heart Team decision-making. The review highlights that clinical translation remains limited and more work is needed before these tools become standard practice.
