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Systematic review and meta-analysis finds 50% prevalence of antipsychotic polypharmacy in MENAT/EMRO countriesHalf of Schizophrenia Patients Take Multiple Drugs at Once

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Key Takeaway
Consider that antipsychotic polypharmacy is prevalent (50%) in MENAT/EMRO countries, with low clozapine use and substantial heterogeneity.

This systematic review and meta-analysis examined the prevalence and correlates of antipsychotic polypharmacy (APP) among patients with schizophrenia and psychotic disorders in Middle East, North Africa, Turkey, and Eastern Mediterranean (MENAT/EMRO) countries. The analysis included 17 studies with 6,053 individuals. The primary outcome was the pooled prevalence of APP, which was 50% (95% CI: 37%-62%), though with substantial heterogeneity (I² = 98.4%).

Among secondary outcomes, the proportion of patients receiving clozapine was 12% (95% CI: 8% to 18%) across nine studies reporting this. APP was associated with a higher number of hospitalizations, but the evidence linking APP to specific demographic and clinical variables was limited to a few studies. The overall certainty of evidence was evaluated using the GRADE conceptual approach.

The authors note substantial heterogeneity as a key limitation, and the evidence on associations with specific variables was limited. Adverse effects were reported as increased with APP, but serious adverse events and discontinuations were not reported.

Clinically, the findings suggest a high prevalence of APP in this region, with relatively low clozapine use. The authors recommend efforts to reduce APP and increase clozapine utilization among eligible patients, though the observational nature of the included studies precludes causal conclusions.

Imagine walking into a clinic for mental health care. You expect a clear plan to help you feel better. Instead, you might leave with a bag full of pills. This situation is common for many people living with schizophrenia.

Schizophrenia affects millions of people around the world. It changes how a person thinks and feels. Many struggle to find the right medicine balance. Doctors often start with one drug to treat symptoms. But some patients end up taking several at the same time. This is called antipsychotic polypharmacy.

Why Do Patients Take So Many Pills?

Think of brain chemistry like a complex traffic system. One medicine might fix one roadblock. Another might handle a different jam. But too many cars cause a crash.

Doctors sometimes add more drugs when the first one does not work. They might try to target different symptoms at once. This approach can feel safer to some clinicians. However, it increases the risk of unwanted reactions.

The Shocking Numbers From the Region

Researchers looked at data from seventeen studies. They included over six thousand patients in the Middle East and North Africa. The review covered countries like Turkey and Egypt.

Half of these patients took multiple antipsychotic drugs. This number is very high compared to other places. It often involves newer types of medication. The data comes from a systematic review of existing research.

This does not mean every patient needs fewer drugs.

But there is a catch. Taking more pills can mean more side effects. It also raises the cost of care. Some patients were hospitalized more often. The review found that polypharmacy was linked to higher hospitalization rates.

Why Clozapine Use Remains Low

Only a small group took clozapine. This is a specific drug for tough cases. Doctors often avoid it due to strict monitoring rules.

Evidence linking this practice to demographics was limited. Some studies found it associated with more hospital stays. The review suggests we need better access to clozapine. Experts say this drug could help many eligible patients.

What Experts Recommend Next

Patients should talk to their doctors about their list. It is important to review every single pill. Some might be safe to stop.

Guidelines are changing to support better care. Clinicians need training on safer prescribing habits. More research will help refine these rules. The goal is to optimize management in the region.

The studies were not all the same quality. Some data came from older records. We need more recent information from these areas. This limits how we can apply the findings everywhere.

Research takes time to reach patients in clinics. Approval processes vary across different countries. We must wait for new trials to confirm safety. This ensures changes are safe for everyone involved.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
Antipsychotic monotherapy is considered the standard for schizophrenia treatment. However, many patients with schizophrenia and other psychotic disorders receive antipsychotic polypharmacy (APP). This can be associated with increased adverse effects, drug interactions, and treatment costs. This review aims to synthesize evidence on the prevalence of APP in the Middle East, North Africa, Turkey, and the Eastern Mediterranean (MENAT/EMRO) countries. Eight databases were systematically searched for studies published up to February 2026 that reported APP prevalence among patients with schizophrenia and psychotic disorders in MENAT and EMRO countries. The methodological quality was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist, while the overall certainty of evidence was evaluated using GRADE conceptual approach (Grading of Recommendations Assessment, Development and Evaluation). The pooled prevalence was estimated using random-effects meta-analysis, and statistical heterogeneity was assessed using tau-squared (τ²) and I² statistic. Potential sources of heterogeneity were explored through subgroup and meta-regression analyses, and publication bias was assessed using funnel plots and Egger’s tests. Seventeen studies with 6,053 individuals with schizophrenia and other psychotic disorders were included. The pooled prevalence of APP was 50% (95% CI: 37%–62%), with substantial heterogeneity (I² = 98.4%), and was commonly associated with second-generation antipsychotics. Evidence linking APP to specific demographic and clinical variables was limited to a few studies, which found APP associated with higher number of hospitalizations. A pooled prevalence across nine of the APP studies revealed that only 12% (95% CI: 8% to 18%) were receiving clozapine. APP is highly prevalent in MENAT/EMRO countries. Given the potential harms of polypharmacy and the limited evidence supporting it, we recommend efforts to reduce APP and increase clozapine utilization among eligible patients. Evidence-based guidelines, clinician training, and improved clozapine accessibility are crucial to optimizing schizophrenia management in the region.
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