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Home › Medications › clozapine

clozapine

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of clozapine

7 trials tracked of clozapine: 4 in phase 3 or 4 and 1 with published results. The most-cited published study has 27 citations.

7Trials tracked
4Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 4 Phase 2 1 Other / NA 2
  1. Phase 4 Telmisartan as an Adjunctive Treatment for Metabolic Problems in Patients With Schizophrenia Completed · 27 cited
  2. Phase 4 Clozapine for Cannabis Use in Schizophrenia Completed
  3. Phase 4 Comparison of Clozapine vs Olanzapine in Childhood-Onset Psychotic Disorders Completed
  4. Phase 4 Treatment of Schizophrenia and Comorbid Cannabis Use Disorder: Comparing Clozapine to Treatment-as-Usual Completed
  5. Phase 2 Electroconvulsive Therapy in Clozapine Refractory Schizophrenia Completed
  6. N/A First Episode Schizophrenia and Cannabis-Related Disorder Study Completed
Show 1 more trials
  1. N/A Biomarker and Safety Study of Clozapine in Patients With Benign Ethnic Neutropenia (BEN) Completed

Showing the 7 most-cited and recently-updated of 7 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Systematic review on genetic factors in treatment-resistant schizophrenia
Genetics & Precision Medicine Sys. Review
Systematic review on genetic factors in treatment-resistant schizophrenia Genetic factors linked to treatment-resistant schizophrenia in European ancestry
This systematic review synthesizes genetic findings in treatment-resistant schizophrenia. It finds that common variants explain little liabi…
A review of 102 studies finds genetic markers are connected to treatment-resistant schizophrenia, but common variants explain little risk.
Frontiers May 20, 2026
Clozapine Use Linked to Higher SARS-CoV-2 Infection Risk in Severe Mental Disorders
Psychiatry Meta-analysis
Clozapine Use Linked to Higher SARS-CoV-2 Infection Risk in Severe Mental Disorders Clozapine users faced higher risk of severe COVID-19 in large study
A meta-analysis of 155,945 outpatients with severe mental disorders found that clozapine users had a higher rate of SARS-CoV-2 infection com…
A massive analysis of over 155,000 people found that those taking clozapine had higher rates of infection and worse outcomes from COVID-19.
May 1, 2026
Systematic review and meta-analysis finds 50% prevalence of antipsychotic polypharmacy in MENAT/EMRO countries
Psychiatry Meta-analysis
Systematic review and meta-analysis finds 50% prevalence of antipsychotic polypharmacy in MENAT/EMRO countries Half of Schizophrenia Patients Take Multiple Drugs at Once
This systematic review and meta-analysis of 17 studies (6,053 individuals) from MENAT/EMRO countries found a pooled prevalence of antipsycho…
New data reveals half of patients with schizophrenia in the Middle East take multiple antipsychotic drugs at once.
Frontiers Apr 29, 2026
Observational study evaluates dynamic prediction model for clozapine initiation in Danish schizophrenia patients
Psychiatry
Observational study evaluates dynamic prediction model for clozapine initiation in Danish schizophrenia patients Can we predict who needs clozapine soon? A new model says yes for many patients
This observational research article evaluates a dynamic prediction model designed to forecast incident clozapine prescriptions within 365 da…
A new model predicts which schizophrenia patients need clozapine within a year, helping doctors start this life-saving treatment sooner for …
medRxiv Apr 21, 2026
Clozapine, olanzapine, or haloperidol reduced assaults in 99 individuals with schizophrenia and assaultive behaviors
Psychiatry RCT
Clozapine, olanzapine, or haloperidol reduced assaults in 99 individuals with schizophrenia and assaultive behaviors Does the right antipsychotic drug reduce violence in people with schizophrenia and conduct disorder?
This RCT evaluated clozapine, olanzapine, or haloperidol in 99 individuals with schizophrenia and assaultive behaviors.
Clozapine reduced violent urges in schizophrenia patients even when their mental symptoms did not improve, suggesting a direct calming effec…
Apr 9, 2026