H2H nutrition management improves PG-SGA scores in malnourished GI cancer patients on chemotherapyCan better nutrition management help cancer patients fight fatigue and stay stronger during chemo?

This randomized controlled trial enrolled 100 gastric or colorectal cancer patients with malnutrition risk (PG-SGA score ≥2) receiving chemotherapy. Patients were assigned to either whole-cycle nutrition management based on the 'Hospital to Home' (H2H) model plus routine nursing (n=50) or routine nursing alone (n=50). The primary outcomes were nutritional status (PG-SGA score) and serum albumin, with secondary outcomes including immune function (CD4+, CD8+ counts, CD4+/CD8+ ratio), hematological parameters, cancer-related fatigue, self-care ability, quality of life, adverse reactions, and nursing satisfaction.

The study group showed significantly greater improvements in PG-SGA score compared to the control group, with a mean difference of -1.4 at cycle 6 (95% CI: -1.9 to -0.9). Secondary outcomes assessing immune function, fatigue, quality of life, and nursing satisfaction were also measured, though specific numerical results for these endpoints were not reported in the provided data. Safety and tolerability data, including adverse events and discontinuations, were not reported.

Key limitations include the lack of reported follow-up duration, study phase, and funding/conflict of interest disclosures. The absence of detailed safety data and specific results for secondary outcomes limits comprehensive assessment. While the improvement in PG-SGA score suggests potential benefit from structured nutritional management in this population, clinicians should interpret these findings cautiously given the limited reporting and need for replication in larger, more comprehensively reported trials.