Selpercatinib tops cabozantinib and vandetanib for PFS in advanced medullary thyroid cancer
Selpercatinib Shows Better Survival for Advanced Medullary Thyroid Cancer
A network meta-analysis of 1,076 patients with advanced medullary thyroid cancer found selpercatinib superior to cabozantinib and vandetanib…
A new analysis of 1,076 patients suggests selpercatinib may offer better progression-free survival than other treatments for medullary thyro…
Elecoglipron results in 40.4% to 88.8% of patients reaching at least 5% weight loss
Trial shows weight loss in adults with obesity using elecoglipron
This Phase 2 randomized controlled trial evaluated elecoglipron in 310 adults with obesity or overweight and a weight-related condition. Par…
A new clinical trial shows that the medication elecoglipron helps people with obesity lose a significant amount of body weight.
Retatrutide Demonstrates Dose Dependent Glycemic Control and Weight Loss in Type 2 Diabetes
Trial shows retatrutide improves blood sugar and weight in diabetes
Phase 3 data reveals retatrutide significantly reduces HbA1c and body weight in adults with type 2 diabetes compared to placebo.
A new trial shows that retatrutide helps people with type 2 diabetes lower their blood sugar levels and lose significant body weight.
Aerobic exercise and high-intensity interval training reduce fat mass in women with overweight or obesity
Vigorous aerobic exercise shows best results for reducing body fat
This systematic review and network meta-analysis of randomized controlled trials evaluated structured exercise interventions for body compos…
Women with overweight or obesity may see the greatest reductions in body fat and BMI through vigorous aerobic exercise programs.
Over half of Arab adults with chronic diseases possess high digital health literacy scores
Older adults with chronic diseases show lower digital health literacy
This cross-sectional survey assessed digital health literacy among 405 Arab adults with diabetes, hypertension, and rheumatoid arthritis in …
More than half of patients with diabetes, hypertension, or arthritis have high digital skills, but older adults face more hurdles using onli…
Performance-enhancing peptides modulating the GH-IGF1 axis present significant risks of endocrine and metabolic disturbances
Risks and evidence levels for popular performance enhancing peptides
This narrative review synthesizes the pharmacological profiles and safety concerns associated with various growth hormone-releasing peptides…
New research clarifies the safety risks and lack of clinical evidence for common growth hormone-related peptides used for performance.
Hormonal transformations during pregnancy and placental contributions influence maternal bone remodeling and metabolism
Pregnancy hormones may trigger rare bone loss condition
This mini review examines the impact of hormonal changes and placental contributions on bone metabolism during pregnancy. The authors synthe…
Hormonal shifts in pregnancy, including placental factors, may explain a rare bone-weakening condition called PLO.
Untreated glucose intolerance in pregnancy linked to postpartum metabolic dysfunction similar to treated GDM
Gestational diabetes impacts metabolic health one year after pregnancy
This planned 12-month follow-up of the GDM2 trial assessed 407 pregnant individuals with varying glucose intolerance. Untreated glucose into…
New research shows that women with high blood sugar during pregnancy face similar metabolic and insulin issues a year later.
Nutritional Supplementation Combined With Exercise Improves BMI And Lipid Profiles In Obesity
Nutritional supplements and exercise may improve weight and cholesterol
Combining nutritional supplements with exercise programs may significantly improve body mass index and lipid profiles in patients with overw…
Combining nutritional supplements with regular exercise can help people with overweight or obesity lower their BMI and improve several key b…
High glucose variability is associated with 2.10 increased risk of all-cause mortality in COVID-19
High blood sugar swings linked to higher COVID-19 death risk
This meta-analysis of 11 datasets involving 77,395 patients found that high glucose variability (GV) is associated with a significantly incr…
Rapidly changing blood sugar levels in hospitalized patients may signal a higher risk of death during a COVID-19 infection.
Non-obese women with PCOS show no significant differences in serum vitamin D levels
Vitamin D Levels Show No Difference in Non-Obese PCOS Patients
This meta-analysis of cross-sectional data examined serum 25(OH)D and 1,25(OH)2D levels in non-obese women with polycystic ovary syndrome. N…
New data suggests that vitamin D levels may be linked to weight rather than the underlying causes of Polycystic Ovary Syndrome.
Once-weekly basal insulin improves HbA1c by 0.09% and time in range over daily regimens
Weekly insulin offers easier management for people with type 2 diabetes
This meta-analysis of 14 randomized controlled trials involving 8,487 subjects found that once-weekly basal insulin analogs provide superior…
A new review of clinical trials shows weekly insulin can manage blood sugar as well as daily shots while reducing the number of injections.