Genome-wide meta-analysis identifies 25 trait-loci associations for cardiometabolic phenotypes in Native Hawaiian and Samoan populations
Native Hawaiian and Samoan DNA study finds new genetic links to diabetes risk
This meta-analysis of a genome-wide association study identifies 25 trait-loci associations for 13 adiposity and cardiometabolic traits in a…
A DNA study of 8,461 Native Hawaiians and Samoans found 25 genetic links to traits like blood sugar and body fat, including 5 that may be ne…
Adipo-B correlates with beta-cell indices in treatment-naive patients with Type 2 Diabetes
New marker may help track insulin production in Type 2 Diabetes
This prospective, non-randomized observational study of 253 treatment-naive patients with Type 2 Diabetes found that adipo-B levels correlat…
A new protein marker could offer a simple way for doctors to track how well the body produces insulin in people with Type 2 Diabetes.
Prenatal exposure to certain psychotropic medications is associated with increased risk of gestational diabetes
Prenatal exposure to certain psychiatric drugs linked to gestational diabetes
This meta-analysis examined the relationship between prenatal exposure to antipsychotics and antidepressants and the risk of gestational dia…
New data shows that some medications used for mental health during pregnancy may increase the risk of gestational diabetes.
Metabolic profiles and specific metabolites serve as potential biomarkers for diabetic kidney disease progression
Metabolites May Help Identify New Pathways in Diabetic Kidney Disease
This systematic review synthesizes the roles of metabolites as signaling hubs and substrates for epigenetic modifications in diabetic kidney…
New research identifies how specific metabolites act as signaling hubs that could help doctors better predict and treat diabetic kidney dise…
Pembrolizumab-induced hypophysitis can cause arginine vasopressin deficiency unmasked by glucocorticoid therapy
Pembrolizumab Treatment Linked to Rare Hormone Deficiency in Lung Cancer
This case report and review describes a patient with metastatic lung adenocarcinoma who developed hypophysitis after pembrolizumab monothera…
A rare case of lung cancer treatment revealed a complex hormone deficiency that only appeared after the patient received steroid therapy.
Telemedicine for gestational diabetes reduces fasting glucose and gestational weight gain in women
Telemedicine Shows Potential for Managing Gestational Diabetes Care
This meta-analysis of 3055 women with gestational diabetes found that telemedicine interventions associated with lower fasting glucose (MD -…
Telemedicine may help manage blood sugar and weight gain in pregnant women with gestational diabetes, though the evidence is currently limit…
Airway epithelial cell and lung macrophage crosstalk provides a basis for targeting asthma endotypes
Lung Cell Communication May Influence Asthma Inflammation Levels
This narrative review explores the airway epithelial cell (AEC) and lung macrophage axis in asthma. The authors conclude that this crosstalk…
New research highlights how communication between lung cells and immune cells can either worsen asthma inflammation or help protect the airw…
Retatrutide Shifts Fatty Acid Oxidation and Insulin Resistance Metabolites in Obesity Trials
New drug retatrutide shows promise for weight loss and diabetes
In phase 2 trials, retatrutide altered two metabolite clusters tied to fatty acid oxidation and insulin resistance, with ketone and acylcarn…
A new medication called retatrutide may help manage weight and insulin resistance by changing specific markers in the blood for people with …
Epidemiological studies report a modest bidirectional inverse association between cancer and Alzheimer disease
Understanding the Complex Link Between Cancer and Alzheimer's Disease Progression
This mini review examines the epidemiological and preclinical links between cancer and Alzheimer disease. It identifies a modest inverse ass…
New research looks at why some people with cancer show a lower risk of dementia. Scientists are studying the complex link between these cond…
Metabolic syndrome prevalence varies significantly based on the specific diagnostic criteria and waist thresholds used
Different Diagnostic Rules Change How Metabolic Syndrome Is Identified
This systematic review examines how different diagnostic frameworks for metabolic syndrome impact prevalence and clinical classification. Th…
Different medical definitions for metabolic syndrome can lead to very different results for how many people are diagnosed with the condition…
Environmental and early-life exposures may influence microRNA expression and immune pathways in Type 1 Diabetes
Early life factors and environmental triggers may impact Type 1 Diabetes
This narrative review explores how environmental factors and early-life exposures influence microRNA expression and pancreatic beta-cell fun…
New research explores how early life factors like infections and diet might influence how the body develops Type 1 Diabetes.
Resistance training improves eGFR in non-dialysis diabetic kidney disease while mind-body exercise reduces UAE
Specific types of exercise may help manage diabetic kidney disease
This systematic review and network meta-analysis of 1,746 patients found that resistance training significantly increased eGFR compared to u…
Different types of exercise, from resistance training to mind-body practices, show different benefits for managing diabetic kidney disease a…