Faecal microbiota transplantation did not significantly reduce HOMA-IR in patients with metabolic disorders
Fecal Microbiota Transplantation Shows Limited Benefit for Insulin Resistance
This meta-analysis of 6 trials involving 120 participants found that faecal microbiota transplantation did not significantly reduce HOMA-IR …
A review of clinical trials suggests that fecal microbiota transplantation may not significantly improve insulin resistance in people with t…
Multidomain intervention did not significantly impact body weight in older adults at risk for dementia
Multidomain lifestyle programs did not change weight in older adults
This post-hoc analysis of a cluster-randomized trial involving 678 older adults with BMI $\geq$ 25 kg/m$^2$ found that a multidomain interve…
A 24-month study shows that a program of diet, exercise, and social activity did not lead to weight loss in older adults at risk for dementi…
Diabetic Retinopathy Tied to Higher Dementia Incidence in Pooled Analysis
Diabetes eye damage may link to higher risk of dementia
Pooled data from nearly 3 million patients link diabetic retinopathy to higher incident dementia, though crude analyses show no significant …
A large study of over 2 million people suggests that eye damage from diabetes is linked to a higher risk of developing dementia.
Hepatocyte senescence and SASP signaling contribute to inflammatory and fibrogenic remodeling in MASLD
Liver Cell Aging May Drive Fatty Liver Disease
This narrative review examines the role of hepatocyte senescence and SASP signaling in metabolic dysfunction-associated steatotic liver dise…
A new review suggests aging liver cells may help drive fatty liver disease, but human evidence is still limited.
Chinese osteoporosis management guidelines show consensus on diagnosis but vary in specific treatment recommendations
Chinese Osteoporosis Guidelines Often Disagree, Review Finds
This systematic review of 32 Chinese guidelines identifies consensus on osteoporosis definitions and diagnostic criteria. However, significa…
A review of 32 Chinese osteoporosis guidelines found broad agreement on basics but sharp splits on specific treatments.
Chinese clinical practice guidelines for osteoporosis demonstrate moderate methodological and recommendation quality scores
Chinese Osteoporosis Guidelines Fall Short on Rigor, Review Finds
This systematic review evaluates the methodological rigor and recommendation quality of 13 Chinese clinical practice guidelines for osteopor…
A review of 13 Chinese osteoporosis guidelines found wide gaps in how rigorously they were developed, with some scoring as low as 25%.
SGLT-2is and GLP-1RAs significantly reduce heart failure related composite endpoints in type 2 diabetes
SGLT2 inhibitors and GLP-1RAs both improve heart failure outcomes
This network meta-analysis of 13,886 patients with type 2 diabetes and heart failure found that both SGLT-2is and GLP-1RAs significantly red…
New data shows both SGLT2 inhibitors and GLP-1RAs effectively reduce heart failure risks for people with type 2 diabetes.
Acute hyperglycemic phenotypes are associated with increased mortality and mechanical ventilation in COVID-19 patients
High Blood Sugar Levels Linked to Worse COVID-19 Outcomes
This meta-analysis examines the association between acute hyperglycemic phenotypes and clinical outcomes in patients with COVID-19. The stud…
New data shows a link between specific high blood sugar patterns and a higher risk of severe outcomes for patients with COVID-19.
Biomarker-guided therapy using MRI signal and granulation patterns optimizes treatment for acromegaly in Gulf region
Biomarker Guidance May Improve Treatment for Acromegaly Patients
This guideline addresses the management of acromegaly in the Gulf region, focusing on biomarker-guided therapy. It suggests using MRI signal…
New guidelines suggest using MRI signals and tumor patterns to help patients with acromegaly achieve better results from their medication.
Multiple biomarkers show potential associations with kidney function decline in patients with type 2 diabetes
Specific Biomarkers May Signal Kidney Decline in Type 2 Diabetes
This systematic review and meta-analysis of 4,569 patients evaluated several biomarkers for detecting kidney function decline in type 2 diab…
New research identifies several biomarkers that may help detect early signs of kidney function decline in people with type 2 diabetes.
South African Guideline Adapts Canadian Obesity Recommendations for Local Care
New clinical guidelines offer practical ways to manage obesity in South Africa
This clinical practice guideline is a South African adaptation of the Canadian Adult Obesity Clinical Practice Guideline. It provides an 18-…
A new 18-chapter guide provides practical, locally-focused ways for South African doctors to treat obesity and manage weight in their patien…
GLP-1 Receptor Agonists in Pregnancy Show No Clear Increase in Most Adverse Outcomes
Large study looks at GLP-1 medications and pregnancy outcomes
This meta-analysis of observational studies examined pregnancy outcomes in women exposed to GLP-1 receptor agonists within 6 months before a…
A large study of over 2 million pregnancies found no clear link between GLP-1 medications and common pregnancy risks like miscarriage or pre…