Pantoprazole Benefits COVID-19 ICU Patients Without Raising Mortality
Trial shows pantoprazole helps prevent gastrointestinal bleeding in COVID patients
In critically ill COVID-19 patients, pantoprazole reduced GI bleeding without increasing mortality, though infection itself worsened outcome…
A study of critically ill patients shows that the medication pantoprazole helps prevent serious stomach bleeding in those with COVID-19.
Serum lactate levels associated with 1.40 odds of unfavorable neurobehavioral outcome in pediatric cardiac arrest
Serum Lactate Levels May Help Predict Outcomes After Cardiac Arrest
This secondary analysis of an RCT involving 213 pediatric patients following out-of-hospital cardiac arrest found that higher serum lactate …
Higher serum lactate levels in children following out-of-hospital cardiac arrest are linked to poorer neurological outcomes and higher morta…
Mechanical Insufflation-Exsufflation Improves Sputum Clearance in Ventilated ICU Adults
Trial Shows Mechanical Insufflation-Exsufflation Improves Sputum Clearance in ICU Patients
Meta-analysis of 310 ventilated ICU adults finds MI-E significantly boosts sputum clearance, though oxygenation remains unchanged.
A new analysis shows that mechanical insufflation-exsuffalation helps clear mucus in critically ill patients on ventilators, though it does …
Volume-controlled mechanical ventilation shows no difference in ROSC compared to manual ventilation in cardiac arrest
Trial results show no difference between mechanical and manual ventilation
This meta-analysis of 13 articles, including 6 randomized trials and 7 non-randomized studies, found no significant difference in return of …
New data shows that using a machine to provide volume-controlled ventilation does not improve survival rates for patients in cardiac arrest.
Early Feeding in VLBW Infants Safe, Cuts Sepsis Risk
Early feeding may reduce sepsis in very low birth weight infants
Meta-analysis finds early enteral feeding in VLBW infants reduces sepsis and time to full feeds without increasing NEC or mortality.
Early feeding within 72 hours may help very low birth weight infants reach full nutrition faster and reduce the risk of sepsis.
Bystander CPR increases 30-day survival odds by 50% in out-of-hospital cardiac arrest
Bystander CPR Linked to Higher Survival After Cardiac Arrest
This meta-analysis of observational studies involving 2,914,595 events indicates that bystander CPR is associated with significantly higher …
Bystander CPR is linked to significantly higher survival rates for people experiencing cardiac arrest outside of a hospital setting.
Neutrophil-to-lymphocyte ratio shows 83.9% sensitivity and 83.9% specificity distinguishing dengue from COVID-19
Neutrophil-to-lymphocyte Ratio Helps Distinguish Dengue From COVID-19
This meta-analysis evaluated the diagnostic accuracy of the neutrophil-to-lymphocyte ratio (NLR) for distinguishing dengue fever from COVID-…
A blood test ratio may help doctors tell the difference between dengue fever and COVID-19 infections in patients showing similar symptoms.
Butyrylcholinesterase activity predicts in-hospital mortality in critically ill adults with sepsis
Butyrylcholinesterase levels help predict survival in patients with sepsis
This individual participant data meta-analysis of 482 critically ill adults with sepsis found that higher Day-1 butyrylcholinesterase (BChE)…
Doctors may soon use butyrylcholinesterase levels to better predict which critically ill patients with sepsis are at higher risk of dying.
Stem cell-derived exosomes facilitate cutaneous wound healing and attenuate scarring via signaling pathway modulation
Stem Cell Exosomes May Help Heal Skin Wounds and Scarring
This systematic review examines the role of various stem cell-derived exosomes in skin wound repair. The authors conclude that these exosome…
New research suggests that stem cell-derived exosomes could help heal skin wounds faster while reducing the formation of scar tissue.
Lumbar puncture identifies subarachnoid blood while CT angiography facilitates rapid vascular assessment in SAH
Lumbar Puncture and CT Angiography Help Diagnose Brain Bleeding
This clinical guideline addresses the management of patients with suspected subarachnoid hemorrhage (SAH) and non-diagnostic head CT scans. …
Doctors use different imaging tools to find brain bleeds when initial scans are unclear, balancing the need for speed against accuracy.
Risk prediction models demonstrate good performance for identifying patients at risk of postherpetic neuralgia
New models help predict chronic pain after shingles infections
This meta-analysis evaluated the predictive performance of various models used to identify patients at risk for postherpetic neuralgia. The …
Doctors are using new prediction models to identify who is at risk for long-term nerve pain after a shingles infection.
Evaluating Carbocisteine and Hypertonic Saline for Management of Acute Respiratory Failure
Trial shows two common treatments do not shorten ventilator time
A large multicenter trial indicates that neither carbocisteine nor hypertonic saline reduces ventilation time, while both increase specific …
A large trial found that adding specific medications did not help patients breathe on their own sooner and may have caused side effects.