Exercise training increases circulating s-Klotho levels in adults with CKD and sarcopenia
Exercise Training Increases Klotho Levels in People with Kidney Disease
This meta-analysis of 893 participants evaluated the impact of various exercise modalities on s-Klotho and FGF23 levels. The analysis found …
Regular exercise training, including resistance and high-intensity intervals, may increase Klotho levels in adults with kidney disease and d…
Short-course ceftriaxone reduces hospital stay and adverse events in children with pneumonia
Shorter antibiotic courses may help children with pneumonia stay home
This randomized controlled trial of 200 children aged 1 to 14 years found that short-course ceftriaxone (5 to 7 days) resulted in shorter ho…
A new trial shows that a shorter course of ceftriaxone can reduce hospital stays and side effects for children with pneumonia.
Hybrid fractionation and Lattice boost provide pain relief and necrosis in inoperable pleomorphic liposarcoma
Hybrid Radiation Approach Shows Promise for Inoperable Soft Tissue Sarcoma
This case report and literature review describes a hybrid fractionation approach for a large, inoperable pleomorphic liposarcoma. The treatm…
A new radiation technique may offer pain relief and reduced tumor consistency for patients with large, inoperable soft tissue sarcomas.
Topical capsaicin 8% patches improve pain in HIV neuropathy, meta-analysis finds
Capsaicin patches may help reduce pain for people with HIV
This meta-analysis assessed the effect of 8% topical capsaicin patches on pain in patients with HIV-induced polyneuropathy. Pooled results s…
A new review suggests that topical capsaicin patches can help manage nerve pain for people living with HIV.
Measurable targets in National Action Plans are essential for effective antimicrobial resistance mitigation and accountability
Clearer goals needed to fight growing drug resistant infections
This perspective article examines the current landscape of National Action Plans (NAPs) regarding antimicrobial resistance. The authors argu…
Many national plans to fight drug-resistant germs lack specific targets, making it harder to track progress and hold systems accountable.
Doxycycline significantly reduces Wolbachia burden in patients with bancroftian filariasis
Doxycycline Reduces Wolbachia Burden in Lymphatic Filariasis Patients
This meta-analysis evaluates the impact of doxycycline on Wolbachia burden and microfilarial counts in patients with bancroftian filariasis.…
Doxycycline may reduce Wolbachia levels in patients with lymphatic filariasis, though its impact on lymphedema remains limited.
HPV16 constitutes 92.5% of single infections in oropharyngeal squamous cell carcinoma cases
HPV16 Remains the Most Common Type in Throat Cancer
This meta-analysis of 183 studies involving 17,443 patients identifies HPV16 as the predominant genotype in oropharyngeal squamous cell carc…
A large global study of over 17,000 cases shows that HPV16 is the primary driver of most HPV-related throat cancers.
Group B Streptococcus Prevalence and Antimicrobial Resistance in African Populations
New data reveals high antibiotic resistance in Group B Streptococcus
A large-scale meta-analysis reveals high rates of GBS vertical transmission and significant resistance to tetracycline in African maternal c…
New data shows high rates of antibiotic resistance in Group B Streptococcus, a common bacteria that can affect newborns and pregnant women.
Doxycycline is the best supported alternative to benzathine penicillin for treating infectious syphilis
Doxycycline shows promise as syphilis treatment alternative
This systematic review and network meta-analysis of 1623 participants evaluates alternative treatments for infectious syphilis. The analysis…
A new review suggests doxycycline may cure syphilis when penicillin isn't an option, but the evidence is weak.
Beta-lactam/beta-lactamase inhibitor therapy reduces all-cause mortality in multidrug-resistant Gram-negative infections
Combination Therapy Shows Better Outcomes for Gram-Negative Infections
This systematic review and network meta-analysis of 1760 patients found that beta-lactam/beta-lactamase inhibitor therapy significantly redu…
Combining certain antibiotics may lower death rates and reduce kidney damage for patients with multidrug-resistant Gram-negative infections.
Evaluating the Efficacy of Behavioral Interventions to Improve Antiretroviral Therapy Adherence
Support and Reminders Improve Medication Adherence for People with HIV
A network meta-analysis of 164 trials demonstrates that reminders, counseling, and supporter-based interventions significantly improve ART a…
Support systems and reminders can significantly improve how well people with HIV stick to their daily antiretroviral medication schedules.
Adequate treatment for maternal syphilis reduces stillbirth odds by 84% in pregnant women
Adequate Treatment for Syphilis Linked to Lower Stillbirth Rates
This meta-analysis of global data indicates that treatment adequacy for maternal syphilis is a primary driver of reduced stillbirth risk. Wh…
Adequate treatment for syphilis in pregnant women is linked to a significant reduction in stillbirth rates compared to inadequate treatment.