Low antimicrobial resistance in Lawsonella clevelandensis infections suggests susceptibility to penicillins, carbapenems, clindamycin, and metronidazole
Doctors find specific bacteria cause deep abscesses in fat tissue
This narrative review of 27 publications, including 18 clinical cases, examines Lawsonella clevelandensis infections in deep-seated abscesse…
A rare bacterium often hides in deep infections of the breast and abdomen, making it hard to treat without a high index of suspicion.
Digital twin technology offers potential for precision dosing and antimicrobial stewardship in complex pharmacotherapy
Digital Twin Technology Could Personalize Medication Dosing
This narrative review explores the integration of digital twin technology into precision pharmacotherapy to manage complex therapies. The au…
Digital twins, virtual patient models, may help tailor drug doses and manage complex medication plans, but clinical proof is still needed.
Chlamydia trachomatis infection prevalence varies significantly across Canadian populations and anatomical sites
New data reveals how common chlamydia is in Canada
This meta-analysis of 169 publications synthesized 437 prevalence measures for Chlamydia trachomatis in Canada. The findings indicate varyin…
Recent data shows that over half of the Canadian population has had a chlamydia infection at some point in their lives.
Seven genome-wide significant loci and eight HLA alleles associated with shingles susceptibility identified
Genetic Links Connect Shingles to Stroke and Lupus Risk
This meta-analysis of a large genome-wide association study identifies seven genomic loci, including IGHG1 and IFNAR2, linked to shingles. M…
New research identifies specific genetic markers for shingles and suggests a potential link between the virus and conditions like stroke and…
Neonatal neutrophil function varies by assay; chemotaxis and NETs often constrained
Understanding How Immune Cells Protect Newborns from Serious Infections
This mini review synthesizes human neonatal studies on neutrophil function. Chemotaxis and extracellular-trap formation are often developmen…
New research looks at how white blood cells in babies fight infections while trying to avoid causing tissue damage.
Doxycycline postexposure prophylaxis associated with increased antimicrobial resistance markers in Neisseria gonorrhoeae infections
Doxycycline Use Linked to Increased Antibiotic Resistance in Gonorrhea
This trial substudy investigated the impact of DoxyPEP on antimicrobial resistance in men who have sex with men on HIV preexposure prophylax…
A clinical trial sub-study found that using doxycycline as a post-exposure treatment may lead to higher rates of antibiotic resistance in go…
TCM addition to hemodialysis increases overall response rate in uremia by RR 1.460
Traditional Chinese medicine improves nutritional status for patients with uremia
This meta-analysis of randomized controlled trials evaluated traditional Chinese medicine (TCM) for patients undergoing maintenance hemodial…
Adding traditional Chinese medicine to dialysis may improve nutrition and overall response rates for people living with uremia.
Resistance exercise is the most effective physical activity for improving self-esteem in children and adolescents
Resistance exercise tops other workouts for kids' self-esteem
This network meta-analysis of 17 RCTs indicates that resistance exercise has the highest probability of being the most effective interventio…
A new analysis of 17 trials finds resistance exercise may be the best workout for boosting self-esteem in kids and teens.
Berberine trial protocol aims to assess 2-year DFS in stage IIIB, IIIC colorectal cancer
Trial Plans to Test Berberine for Colorectal Cancer Patients
This randomized controlled trial protocol will compare berberine versus placebo in 306 patients with stage IIIB, IIIC colorectal cancer afte…
A new clinical trial plans to see if the compound berberine can help prevent cancer from returning after surgery.
Tuberculosis prevalence among children with severe acute malnutrition is 13% (95% CI: 11-16%)
Tuberculosis is common among children with severe acute malnutrition
This meta-analysis of 33,869 children across 15 countries identifies a pooled tuberculosis prevalence of 13% in those with severe acute maln…
Over 13% of children suffering from severe acute malnutrition also have tuberculosis, highlighting a critical need for integrated screening.
Papilloguard with AS04 shows non-inferior immunogenicity to Gardasil in HPV vaccine trial
Trial Shows Papilloguard Vaccine Provides Strong Protection Against HPV Infection
This Phase III RCT in 670 healthy individuals aged 15-25 years found that Papilloguard (quadrivalent HPV vaccine with AS04) was non-inferior…
A new trial shows the Papilloguard vaccine provides strong antibody levels against four types of HPV, similar to current standard treatments…
WGS-based tools provide high specificity and sensitivity for rifampicin, isoniazid, and fluoroquinolone resistance detection
New tools help doctors identify drug resistant tuberculosis strains
This meta-analysis of 144,623 M. tuberculosis genomes evaluates six open-access WGS-based drug susceptibility testing prediction tools. The …
New computer tools can accurately predict if common drugs will work against tuberculosis, helping doctors choose the right treatment faster.