Weight Regain Reverses Caloric Restriction Benefits on Insulin-IGF-1 Pathway and Biological Age
Weight Regain Undoes Caloric Restriction Benefits For Diabetes Risk
This post hoc analysis of the CALERIE-2 trial examined 190 participants who underwent 25% caloric restriction or control diet.
Losing weight helps control diabetes risk, but gaining those pounds back undoes the hormonal benefits and reverses progress made during the …
Two-year caloric restriction attenuated biological age increases across multiple organ systems in a randomized trial
Eating Less Slows Aging in Heart and Metabolism Systems
This Phase 2 randomized controlled trial evaluated 185 participants assigned to sustained caloric restriction or an ad libitum diet.
Eating less food may actually slow down aging in your heart and metabolism while keeping other organs stable.
Semaglutide reduces insulin dose in adults with type 1 diabetes and obesity
Semaglutide Cuts Insulin Needs By Half In Type 1 Diabetes
A post hoc analysis of an RCT found that semaglutide 1 mg/week significantly reduced total daily insulin dose by 22.6% over 26 weeks in adul…
Semaglutide reduces insulin needs quickly in type 1 diabetes patients, offering a new hope for better blood sugar control and weight managem…
Systematic Review and Meta-Analysis: Bariatric Surgery Reduces Low Back Pain in Morbid Obesity
Metabolic surgery reduces back pain and improves spinal health in morbidly obese adults
This systematic review and meta-analysis of 390 morbidly obese adults found that metabolic and bariatric surgery significantly reduced low b…
Metabolic surgery significantly reduced back pain and improved quality of life for morbidly obese patients with low back pain, though spinal…
Resistance exercise and high protein diet improved metabolic flexibility in older men over 12 weeks
Resistance exercise and high protein diet improved metabolic flexibility in older men
This randomized controlled trial involved 33 older men.
A 12-week trial found that resistance exercise and high protein diet improved metabolic flexibility in older men compared to doing nothing.
Wholegrain rye diets improve metabolic markers but not weight loss in overweight adults
Wholegrain rye lowers inflammation better than refined wheat for weight loss diets
This 12-week randomized trial compared hypocaloric diets with wholegrain rye versus refined wheat in 255 adults with overweight or obesity.
Switching to wholegrain rye while dieting may lower inflammation and improve gut bacteria even if weight loss is the same
Energy restriction with ultra-processed food restriction yields greater weight loss than generic energy restriction in obesity
Low-Processed Food Diet May Help People With Obesity Lose More Weight
This randomized clinical trial enrolled 148 individuals with obesity and compared energy restriction associated with ultra-processed food re…
A trial found that restricting ultra-processed foods alongside calorie limits helped people with obesity lose more weight and reduce ultra-p…
Exploratory analysis of RYGB and SG shows variable LDL cholesterol response in patients with obesity and high LDL cholesterol
Two bariatric surgeries lower cholesterol through completely different biological paths
This exploratory analysis of a randomized clinical trial (BASALTO) evaluated 30 patients with obesity and high LDL cholesterol undergoing Ro…
New research shows that two popular weight loss surgeries lower bad cholesterol in very different ways that could change how doctors pick a …
Extended sleep improved sleep metrics but did not change insulin sensitivity in a small trial
Extended sleep improves sleep duration but not insulin sensitivity in small trial
This randomized trial investigated whether extending sleep duration improves metabolic health in people with overweight or obesity and habit…
In a small trial, people with overweight or obesity who slept longer stayed in bed more and felt better, but insulin sensitivity did not imp…
Afternoon/Evening Exercise May Lower Blood Pressure More Than Morning Exercise: Meta-Analysis
Evening exercise lowers blood pressure and sugar better than morning workouts for people with diabetes or high weight
This systematic review and meta-analysis of 625 participants found that afternoon/evening exercise (PmEx) was associated with significantly …
For people with type 2 diabetes or high blood pressure, working out in the afternoon or evening lowers blood pressure and sugar more than mo…
Vegetarianism associated with altered lipid profiles in UK Biobank participants
Vegetarian diets lower cholesterol in UK Biobank participants
This cross-sectional study of UK Biobank participants found that vegetarianism was associated with reduced total, LDL, and HDL cholesterol b…
Vegetarian diets were linked to lower cholesterol levels in a large UK study. This finding applies to people of European, Asian, and African…
Mediterranean diet plus physical activity reduces postprandial triglyceridemia in adults with abdominal obesity
Combining diet and exercise may lower blood fat better than either alone
This randomized controlled trial enrolled two hundred men and women with abdominal obesity and moderate hypertriglyceridemia.
Combining a Mediterranean diet with regular exercise may lower blood fat levels better than doing just one, offering a small but promising b…