Hemithyroidectomy is associated with a 3% higher risk difference in cancer recurrence rate
Hemithyroidectomy linked to higher thyroid cancer recurrence
This meta-analysis of 98,604 patients with differentiated thyroid carcinoma found that hemithyroidectomy (HT) was associated with a 3% highe…
A large meta-analysis found that hemithyroidectomy for differentiated thyroid cancer has a higher recurrence rate than total thyroidectomy, …
HIFU ranks highest for fibroid volume reduction and hormonal stability in network meta-analysis
High intensity focused ultrasound shows promise for uterine fibroids
This network meta-analysis of 2622 women with symptomatic uterine fibroids indicates that HIFU ranked highest for fibroid volume reduction, …
A review of 2,622 patients suggests high-intensity focused ultrasound is highly effective at shrinking fibroid size and preventing regrowth.
Anti-CD19 shRNA-engineered CAR-T cells achieve an 88% overall response rate in B-cell acute lymphoblastic leukemia
CAR-T Cells Show Promise for B-cell Acute Lymphoblastic Leukemia
This meta-analysis evaluates anti-CD19 shRNA-engineered CAR-T cells (interleukin-6 knockdown) for patients with B-cell acute lymphoblastic l…
New research into modified CAR-T cells shows high response rates in patients with a specific type of leukemia while managing serious side ef…
Olanzapine significantly improves complete response and total control in chemotherapy-induced nausea for breast cancer
Olanzapine helps manage nausea in breast cancer chemotherapy
This meta-analysis of 4 studies involving 857 patients found that olanzapine with regular antiemetic treatment improved complete response (R…
Adding olanzapine to standard care can significantly improve nausea control and complete response for patients undergoing breast cancer chem…
Pseudoprogression in immune checkpoint inhibitor therapy is associated with modest tumor growth and early progression
Immune Checkpoint Inhibitors May Cause Initial Tumor Growth in Cancer
This meta-analysis of retrospective data examines patients with solid tumors experiencing pseudoprogression during immune checkpoint inhibit…
A growing tumor during immunotherapy might actually be a sign that the treatment is working, not a sign that the cancer is spreading.
WBRT yields median survival of 3.6 months in Nigerian brain metastases patients
Brain radiation extends life by 3.6 months in Nigerian patients
This systematic review of 142 patients with brain metastases in Nigeria found that whole brain radiotherapy (WBRT) was associated with a med…
Whole brain radiotherapy gave Nigerian breast cancer patients with brain metastases a median survival of 3.6 months. A new review reveals th…
Immunomodulatory interventions targeting the ovarian immune microenvironment may address functional decline in aging and POI
Immune system changes drive ovarian aging and fertility decline
This systematic review examines how dysregulation of the local ovarian immune microenvironment, including Treg/Th17 balance and macrophage p…
New research identifies how the immune environment in the ovaries drives age-related decline and may offer a path for new treatments.
Luspatercept and ESA-based regimens show higher rates of erythroid haematological improvement in lower-risk MDS
Different Medications Show Different Benefits for Myelodysplastic Syndromes
This systematic review and network meta-analysis of 20 trials involving 2,877 participants evaluated pharmacological treatments for lower-ri…
New research shows different medications offer varying benefits for patients with lower-risk myelodysplastic syndromes based on specific hea…
Intracranial immunotherapy delivery does not improve survival for pediatric high-grade glioma compared to systemic administration
Intracranial Delivery Shows Higher Neurotoxicity Risk in Pediatric Brain Tumors
This meta-analysis of 22 studies evaluated intracranial versus systemic immunotherapy delivery in pediatric patients with high-grade and dif…
New analysis shows that while delivery methods do not change survival for pediatric brain tumors, some routes carry a higher risk of severe …
PD-1 inhibitors plus chemotherapy achieve 64% objective response rate in recurrent or metastatic nasopharyngeal carcinoma
Different PD-1 Inhibitors Show Varying Results for Nasopharyngeal Cancer
This systematic review and meta-analysis of 1,459 patients with recurrent or metastatic nasopharyngeal carcinoma found a pooled objective re…
A review of 1,459 patients shows that different PD-1 inhibitors combined with chemotherapy offer varying survival and response rates for nas…
Combination strategies using DNA damage response inhibitors aim to overcome resistance in pancreatic cancer
New combination strategies aim to treat pancreatic cancer more effectively
This systematic review evaluates DNA damage response (DDR) inhibitors, including monotherapy and combination regimens, for pancreatic cancer…
Combining different drugs could help overcome treatment resistance and reach more patients with pancreatic cancer.
Radiomics-based machine learning achieves high AUROC for preoperative risk stratification in bladder cancer
Machine Learning May Help Identify Risks in Bladder Cancer
This systematic review and meta-analysis of 57 studies involving 11,933 participants evaluated radiomics-based machine learning for preopera…
New analysis shows machine learning can help identify muscle invasion and tumor grades in patients with bladder cancer using imaging data.