Antithrombotic agents may reduce symptoms in severe mental illness, but evidence is very low certainty
Blood-thinning drugs show possible benefit for severe mental illness symptoms
A systematic review and meta-analysis of 742 patients with severe mental illness found antithrombotic agents may reduce depressive symptoms …
Blood-thinning drugs might slightly ease severe mental illness symptoms, but experts warn the evidence is very uncertain and more research i…
Meta-analysis identifies distinct and shared amygdala connectivity patterns in major depression and bipolar disorder
Do depression and bipolar disorder show different brain wiring patterns?
A voxel-wise meta-analysis of neuroimaging studies compared amygdala functional connectivity in patients with major depressive disorder and …
Brain scans show depression and bipolar disorder have different wiring in memory areas but share abnormalities in emotion control regions.
Scoping review maps 31 U.S. interventions for opioid use disorder during pregnancy by socioecological level
What helps pregnant women with opioid addiction? A new review maps the options
A scoping review of 31 U.S. intervention studies for pregnant individuals with opioid use disorder found 55% focused on individual-level app…
A review of U.S. research found 31 interventions for pregnant women with opioid addiction, with over half focusing on individual care like m…
Systematic review links trauma exposure to epigenetic changes in stress, immune, and neurodevelopmental pathways
Can trauma change our biology in ways that affect our children?
A systematic review examined epigenetic changes associated with acute, chronic, and complex traumatic exposures.
Severe stress can leave molecular marks on the body that affect how we handle stress, our immune system, and even increase vulnerability for…
Nutrition interventions may improve depression, anxiety, and diabetes distress in adults with diabetes
Can changing what you eat help ease the mental burden of diabetes?
A meta-analysis of 30 publications in adults with diabetes found nutrition interventions improved depression and anxiety scores and lowered…
Adjusting your diet to balance proteins, fats, and carbs can lower the specific distress of managing diabetes, though supplements helped eas…
Meta-analysis finds virtual reality exposure therapy reduces anxiety and PTSD symptoms
Can virtual reality help people face their fears? A new analysis suggests it might
A meta-analysis of 26 RCTs involving 1,649 patients with anxiety-related disorders and PTSD found virtual reality exposure therapy significa…
Virtual reality exposure therapy significantly reduces phobia, anxiety, and PTSD symptoms while helping people face their deepest fears.
Meta-analysis finds mixed MRI patterns in subgenual cingulate cortex in medication-free MDD patients
What does depression look like in the brain? The picture is complicated
A systematic review and meta-analysis of 42 publications compared medication-free MDD patients to healthy controls using MRI.
Depression scans show mixed results for brain size and activity, but consistently reveal weaker connections in an emotional hub when the bra…
Psychotropic medications frequently cause metabolic adverse effects via gut-brain axis
Why do psychiatric medications often cause weight gain and diabetes?
A narrative review synthesizes emerging evidence on psychotropic-induced metabolic disturbances.
Psychiatric drugs often cause weight gain and diabetes by disrupting the gut-brain-metabolic axis, a link new science is starting to map.
Transcriptomic meta-analysis in bipolar disorder identifies mitochondrial, synaptic, and inflammatory pathway genes
Gene analysis in bipolar disorder finds links to energy, inflammation, and signaling pathways
A meta-analysis of 917 brain and 638 blood samples from BD patients and controls found enrichment of genes involved in mitochondrial bioener…
Gene analysis reveals that bipolar disorder disrupts brain energy production, stress response, and inflammation pathways, pointing to specif…
Fatal serotonin syndrome in Parkinson's patient on rasagiline after sequential SSRI administration
Case report describes fatal serotonin syndrome in older Parkinson's patient on multiple medications
A case report describes a 72-year-old Parkinson's patient on rasagiline who developed fatal serotonin syndrome after sequential sertraline a…
A 72-year-old Parkinson's patient died after taking two antidepressants with a genetic makeup that slowed drug processing, causing fatal ser…
Protocol for RCT of sequential aTBS for suicidal ideation in adults with MDD
Study protocol tests brain stimulation for depression with suicidal thoughts
This is a study protocol for a single-blind RCT of 56 adults with major depressive disorder and active suicidal ideation.
A new brain stimulation treatment is being tested to reduce depression and suicidal thoughts in adults, using magnetic pulses over 10 sessio…
Group Metacognitive Therapy Shows Large Symptom Reductions in Students with Anxiety
Group therapy for student anxiety shows promising results in small, early study
An uncontrolled pre-post study of students with anxiety disorders or elevated symptoms found group Metacognitive Therapy (gMCT) delivered in…
Group therapy for student anxiety showed large symptom reductions and lasting benefits in an early study at a university clinic in Oslo.