N/A N=204 Safety & Prevention Outcomes Study
Drug Overdose · Opioid-Related Disorders
Primary: Overdose Risk Behavior — -1.54; -0.51 Scores on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=112 Co-Use of Opioid Medications and Alcohol Prevention Study
Alcohol Drinking · Opioid Use
Primary: Alcohol Use Reductions — 11; 12; 1; 1 Participants
N/A N=2,057 The Tobacco, Alcohol, Prescription Medication and Other Substances Tool
Substance Use Disorder
Primary: Diagnostic and Statistical Manual-5 (DSM-5) Alcohol Use Disorder Diagnosis Measured by the Modified World Mental Health Composite International Diagnostic Interview…
N/A N=533 A Digital Intervention to Prevent the Initiation of Opioid Misuse in Adolescents in School-based Health Centers
Opioid Misuse
Primary: Percentage Reporting 'Great Perceived Risk of Harm' From Opioid Misuse — 66; 53 Participants
N/A N=61 AESOPS Trial 2 (AESOPS-2): Availability of Opioid Harm
Opioid Abuse
Primary: Change in Daily Average Number of 5 MME Pill Counts — -3.73; 3.89; 9.8; -4.85 Difference in estimated mean pill counts — p=0
N/A N=843 Personalized Health Assessment Related to Medications (Project PHARM)
Feedback, Psychological · Clinical Trial · Substance Abuse
Primary: Change in Past 6 Month Non-Medical Use of Prescription Stimulant Medication Frequency — -2.04; -1.72; -1.03; -.38 Usage days — p=0.03
N/A N=49 Consensus-based Algorithms to Address Opioid Misuse Behaviors Among Individuals Prescribed Long-term Opioid Therapy
Opioid Misuse · Chronic Pain
Primary: Feasibility of Algorithms — 7; 13 Participants
N/A N=80 Mobile Application for Prescription Drug-Abuse Education (MAPDE)
Prescription Drug Abuse (Not Dependent)
Primary: Current Opioid Misuse Measure (COMM) — .72; .71; .62; .63 score on a scale — p=.72
N/A N=235 Preventing Prescription Stimulant Diversion and Medication Misuse Via a Web-Based Simulation Intervention
Prescription Drug Abuse (Not Dependent) · Intentional Misuse
Primary: Frequency of Prescription Stimulant Diversion — .25; .41; .18; .30 Mean number of times diverted — p=.499
N/A N=55 Clinical Decision Support for Opioid Use Disorders in Medical Settings: Usability Testing in an EMR
Opioid-use Disorder
Primary: Intervention PCP Confidence in Assessing and Treating OUD — 6; 11; 8; 1 Participants
Phase 2 N=16 A Study to Evaluate the Abuse Potential of Oxymorphone Compared to Other Mu Opioid Agonists.
Opioid Use Disorder
Primary: Positive Subjective Drug Effects (i.e., Drug "Liking"). — 52.1; 57.5; 71.8; 71.5 units on a scale — p=.0001
N/A N=33 A Digital Intervention to Prevent Initiation of Opioid Misuse in Adolescents in School-based Health Centers
Opioid Misuse
Primary: Knowledge Questions — 100 Percentage of Questions Correct
Phase 2 N=32 Effects of Pioglitazone, a PPARgamma Receptor Agonist, on the Abuse Liability of Oxycodone
Opioid Abuse
Primary: Subjective Ratings of "Good" Drug Effect — 37; 35; 35 units on a scale
N/A N=63 Consortium to Disseminate and Understand Implementation of Opioid Use Disorder Treatment
Opioid Medication Assisted Treatment
Primary: Number of Patients Within Participating Sites With OUD Initiating MOUD During the Implementation Facilitation Period in Implementation Sites. This Will be Compared to…
N/A N=134 Records for Alcohol Care Enhancement
Alcohol Use Disorder (AUD)
Primary: Percent of New Alcohol Use Disorder (AUD) Diagnosis Episodes That Meet Criteria for AUD Treatment Engagement Among Patients With a New AUD Diagnosis Who Are Empaneled to…
N/A N=76 Evaluation of a Computerized Opioid Overdose Prevention Program
Computer + Fluency · Computer Only · Treatment as Usual
Primary: Knowledge Gain — 30.6; 30.5; 27.56; 40.7 units on a scale
Phase 2 N=42 Enhancing the Effects of Adolescent Alcohol Treatment With Atomoxetine
Alcohol Use Disorder
Primary: Completion Rates — 17; 18 Participants
N/A N=95 Assessing the Feasibility of Economic Approaches to Prevent Substance Abuse Among Adolescents
Adolescent Drinking · HIV/AIDS · Drug Use
Primary: Percentage of Participants Completing the Study at 6 Months — 44; 46 Participants
Phase 2 N=49 Study of the Relative Abuse Potential of Acurox Tablets in Non-Dependent Recreational Opioid Users
Opioid Abuse
Primary: Drug Liking at .5 Hours — 66.0; 74.7; 47.7; 40.9 score on a scale
Phase 1 N=75 A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Abusers
Healthy
Primary: Drug Liking: Peak Effect (Emax) — 51.6; 70.1; 85.5; 59.3 mm — p=<0.0001
N/A N=31,432 Data-driven Identification for Substance Misuse
Substance Use · Substance Abuse · Substance-Related Disorders
Primary: Proportion of Patients That Had a Universal Screen Positive and Received SBIRT (Screening, Brief Intervention, or Referral to Treatment) — 1189; 1144 Participants — p=0.20
N/A N=44 Pilot Study of a Computer-Based Intervention for Alcohol Misuse in the Emergency Department
Alcohol Consumption
Primary: Change in Youth Alcohol Use — -0.44; -0.88; -0.06; -0.96 units on a scale
N/A N=18 Atomoxetine/Attention Deficit/ Hyperactive Disorder (ADHD)/Substance Use Disorder (SUD)in a Residential Treatment Facility
Attention Deficit Hyperactivity Disorder
Primary: Change in Adult ADHD Investigator Symptom Rating Scale Score — 17.3 units on a scale
N/A N=16 Usability Testing for the Reward-based Technology to Improve OUD Treatment
Opioid-use Disorder · Contingency Management · Medication for Opioid-use Disorder
Primary: OARSCM Usability - Phase 1 Usability — 12 Participants
Phase 2 N=376 Enhancing Prevention Capacity With Developmental Assets and Getting to Outcomes
Substance Abuse
Primary: Prevention Capacity-GTO Efficacy (Intent to Treat) — 63.38; 59.79; 61.37; 58.71 percentage of the highest possible score — p=.58
Phase 2 N=12 Modafinil for the Treatment of Alcohol Use Disorders
Alcohol Use Disorder
Primary: Time to Relapse — 16; 43 days
N/A N=86 Feasibility of SBIRT-PN
Substance Use · HIV/AIDS · Older Adults
Primary: Number of Participants Ranking Intervention as Acceptable — 9; 5 Participants
N/A N=1,804 A High School Program for Preventing Prescription Drug Misuse
Prescription Drug Abuse · Substance Abuse · Substance Use (Drugs, Alcohol)
Primary: Prescription Drug Misuse (i.e., Prescription Drug Use Without a Doctor's Prescription) — 1.06; 1.12; 1.11; 1.13 score on a scale
N/A N=62 Stigma and a Shared Decision Aid
Opioid Use Disorder
Primary: Patient Internalized Stigma Towards Medicaid for Opioid Use Disorder (MOUDs) Over the Course of the Project — 15; 11; 14; 8 score on a scale — p=0.32
Phase 1 N=45 A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Users When ALO-02 Capsules Are Crushed and Snorted
Healthy
Primary: Drug Liking: Peak Effect (Emax) — 50.9; 60.5; 51.3; 92.8 mm — p=0.0001