Clinical Trial Search

Primary: Cocaine Self-administration — 0; 0; 0; 2.2 Number of doses purchased

Primary: Endothelin-1 Levels — 2.15; 2.063; 1.956 pg/ml

Primary: Regional Availability of Metabotropic Glutamate Type-5 Receptors (mGluR5) — 36.48; 32.19; 25.67; 22.41 mL*cm^3 — p=0.035

Primary: Percent Days Abstinent From Cocaine - Self Report — 72.9; 72.9; 59.3 percentage of days — p=.10

Primary: Longest Duration of Abstinence From Cocaine — 4.14; 6.64; 6.93 weeks — p=.01

Primary: Cocaine Use Over Time — 0.01; 0.007; -0.01; 0.007 slope (change in prob of coc-pos utox/d) — p=<0.05

Primary: Proportion of Cocaine Positive Urine Tests Per Week — .57; .58 Proportion of cocaine positive — p=0.84

Primary: Three Weeks of Cocaine Abstinence at End of Study — 9; 0 Participants

Primary: Functional Connectivity Between Corticolimbic Brain Regions During Acute Social Stress — .011; .012; .043; .0008 Arbitrary units

Primary: Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 1.0; 0.1; 3.4; 3.9 Number of Cocaine Choices

Primary: Cocaine Intoxication — 59; 51; 45; 44 units on a scale

Primary: Performance on the Cambridge Neuropsychological Test Automated Battery (CANTAB) - RVIP Reaction Time — 407.7; 476.8; 427.4; 379.2 milliseconds — p=0.006

Primary: Three Weeks of Continuous Cocaine Abstinence as Measured by Urine Toxicology and Self Report Based on Time Line Follow Back — 13; 7 participants — p==.05

Primary: Reinforcing Effects of Cocaine — 1.4; 4; 4.5; 0.7 number of times subjects chose cocaine

Primary: Visual Analog Scale Subjective Rating of Drug Effects — 8.65; 9.85; 13.65; 10.43 units on a scale

Primary: the Adult ADHD Rating Scale (AARS) (30% Reduction) — 50 percent of participants

Primary: The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 0.06; 0.94; 0.75; 0.88 cocaine choices

Primary: The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 2.75; 1.38; 1.38; 4.75 cocaine choices

Primary: Number of Participants That Achieved Study Compliance — 22; 15; 18 Participants

Primary: % Urine Samples Negative for Cocaine — .67; .74 percentage of positive urine samples

Primary: Cocaine Use as Assessed by Proportion of Visits (Excluding Excused Absences) With Cocaine-negative Urine Drug Screen — 0.31; 0.24 proportion of visits

Primary: Last Three Weeks of Cocaine Abstinence Based on Urine Toxicology Results and Self Reported Use — 7; 18; 30 percentage of participants

Primary: Cocaine Use as Assessed by the Treatment Effectiveness Score (TES), Which is the Total Number of Cocaine-negative Urines During Treatment — 9.25; 6.09; 6; 4.91 number of…

Primary: Cocaine Safety in Subjects Receiving Donepezil — 0; 2 Participants with an Adverse Event

Primary: Subjective Stress Response TSST — 5.33; 5.28; 2.05; 2.13 units on a scale

Primary: Change of Thrice Weekly Cocaine Free Urine Toxicology From Week 1 to 13 — 6; 0; 3; 2 participants that were cocaine free — p=0.09

Primary: Cocaine Craving — 4.8; 3.4; 3.0; 2.7 units on a scale

Primary: Longest Duaration of Achieved Abstinance — 0; 7; 1; 8 number of participants

Primary: %Cocaine Free Urines — 52; 26 percent

Primary: Weekly Cocaine Use — 1.1; 1.3 days