Phase 4 N=60 A Comparison of Proprietary Formulations of Oral Ketamine + Aspirin and Oral Ketamine Alone for Musculoskeletal Pain
Pain
Primary: Change in Pain Score at 60 Minutes — 2.18; 4.01 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=393 Acetaminophen (APAP) +/- Oxycodone
Musculoskeletal Pain
Primary: Change in Pain Assessment — 2.9; 4.0 score on a scale
N/A N=330 Reducing the Transition From Acute to Chronic Musculoskeletal Pain Among Older Adults
Acute Musculoskeletal Pain · Chronic Pain
Primary: Mean Brief Pain Inventory-Short Form (BPI-SF) Combined Pain Severity and Interference Score — 2.67; 2.99; 2.94; 1.90 score on a scale — p=0.13
Phase 4 N=416 Comparative Efficacy of 4 Oral Analgesics
Pain
Primary: Between Group Difference in Change in Numerical Rating Scale (NRS) Pain Scores — 4.4; 3.5; 3.9; 4.3 units on a scale
Phase 2 N=90 Ibuprofen Versus Acetaminophen vs Their Combination in the Relief of Musculoskeletal Pain in the Emergency Setting
Pain
Primary: Pain Severity — 39; 43; 42 mm
Phase 2 N=164 Bonipar for Acute and Chronic Musculoskeletal Pain
Chronic Pain · Musculoskeletal Pain
Primary: Change in Pain as Measured by Subjective Pain Intensity Rating (SPIR) — -2.3; -2.6 score on a scale — p=0.46
Phase 4 N=240 Orphenadrine and Methocarbamol for LBP
Low Back Pain
Primary: Functional Impairment as Measured on the Roland Morris Disability Questionnaire — 10.9; 9.4; 8.1 units on a scale
N/A N=75 Patient Education to Improve Pain Management in Older Adults With Acute Musculoskeletal Pain: A Pilot Randomized Trial
Musculoskeletal Pain
Primary: Change in Pain Score — -1.3; -2.4; -3.0 score on a scale
N/A N=240 Strategies for Prescribing Analgesics Comparative Effectiveness Trial
Back Pain · Osteoarthritis
Primary: Brief Pain Inventory Interference Scale — 3.7; 3.7; 3.4; 3.6 units on a scale
Phase 4 N=323 A Randomized Study of Three Medication Regimens for Acute Low Back Pain
Acute Low Back Pain
Primary: Change in Functional Disability as Measured by the Roland Morris Disability Questionnaire — 5; 4; 7 units on a scale
N/A N=42 Quantifying Myofascial Dysfunction in Post-Stroke Pain
Myofascial Dysfunction
Primary: T1 Rho MRI Relaxation Time of Shoulder External Rotator (Milliseconds) — 29.09; 27.15 milliseconds
Phase 3 N=1,000 Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain
Acute Pain · Low Back Pain, Mechanical
Primary: Pain Intensity — 2.8; 3.0; 2.8; 3.0 score on a scale — p=0.16
N/A N=41 Exercise Dosing for Pain in Healthy Participants
Pain
Primary: Intervention Effects on Mechanical Sensitivity Threshold — 125.6; 93.56; 63.04; 70.27 100*Value at 24 hours/Value at Baseline
N/A N=34 Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training
Sarcopenia · Osteoporosis · Aging
Primary: Change in Total Body Fat-free Mass — 1.5; 2.3; 0.7 kg — p=0.38
Phase 4 N=110 Intramuscular Ketorolac at Two Single-Dose Regimens
Musculoskeletal Pain · Analgesia · Adverse Event
Primary: Mean Difference of Visual Analog Scale Scores — -29.74; -29.85 score on a scale
N/A N=501 Oral Analgesic Utilization for CHildhood Musculoskeletal Injuries
Musculoskeletal Injury
Primary: Pain Intensity - Percentage of Children Who Achieved VAS < 30 mm — 33.0; 29.3; 29.9 Percentage of participants — p=0.81
Phase 3 N=120 Ibuprofen With or Without Acetaminophen for Low Back Pain
Low Back Pain
Primary: Change in Functional Impairment as Measured by the Roland Morris Disability Questionnaire — 11.1; 11.9 units on a scale
Phase 3 N=23 Efficacy of Lidocaine Patch in Acute Musculoskeletal Pain in the Emergency Department
Acute Musculoskeletal Disease · Sprains · Sprains and Strains
Primary: Change in Numerical Pain Rating Scale — 2.9; 2.1 score on a scale
N/A N=1,002 The Maintaining Musculoskeletal Health Study
Widespread Chronic Pain
Primary: Development of Chronic Widespread Pain Assessed by Questionnaire — 69; 77 Participants
Phase 3 N=100 The Use of Methylsulfonylmethane (MSM) in the Treatment of Low Back Pain
Low Back Pain
Primary: Pain Level — 3.4; 3.7; 2.8; 2.9 score on a scale
N/A N=20 Usability of a Multimodal External Neuromodulatory Device to Relieve Acute Low Back Pain
Low Back Pain · Low Back Sprain · Low Back Pain, Recurrent
Primary: Change in Pain: Visual Analog Scale (VAS) — 2.1 units on a scale (centimeters)
N/A N=128 Subacute Low Back Pain in Active Duty
Subacute Low Back Pain
Primary: Lower Back Strength-Extension — 54.5; 50.2; 49.2; 57.5 kg-Force
Phase 2 N=11 Trigger Point Injection in Reducing Pain Following Total Knee Arthroplasty
Trigger Point Pain, Myofascial
Primary: Pain Scores on the Visual Analog Scale — 51; 55; 40; 42 Pain Scores on the Visual Analog Scale
Phase 3 N=205 Topical Ibuprofen for Delayed Onset Mulscle Soreness
Pain
Primary: Change From Baseline in the Time-Weighted Sum of Muscle Soreness With Movement Over 0-24 Hours Post-Dose 1 (MSM 0-24 ) — 22.2; 17.8; 29.7 units on a scale — p=0.200
N/A N=51 Marijuana Use, Strength Training, and Alcohol Consumption (MUSTAC) Study
Chronic Pain
Primary: Alcohol Demand: Breakpoint — -6.00; -2.07; -1.81; -1.09 dollars/drink — p=.26
N/A N=20 Cramer Sports Motion Tape and Low Back Pain EMG
Low Back Pain
Primary: Percent of Maximal Voluntary Isometric Contraction (%MVIC) — 226.41; 250.51; 162.47; 205.82 % of Max Voluntary Isometric Contraction
N/A N=108 Natural History of Pain After Shoulder Arthroplasty Conducted With Multimodal Analgesia
TSA · Bruise · Pain, Postoperative
Primary: Numeric Rating Scale Pain Scores at Post-operative Day 14 — 1.6; 3.1 score on a scale
N/A N=148 Effect of Personalized Pain Coaches After Orthopaedic Surgery for Patients With Sports Medicine Injuries
Sports Medicine Injuries
Primary: Pain Numerical Rating Scale (NRS) — 3.24; 3.04; 2.98; 3.02 score on a scale
N/A N=24 Development and Validation of a Digital Pain-Reduction Kit for Musculoskeletal Injuries
Pain, Acute · Pain, Chronic
Primary: PROMIS - Physical Function Short Form 8b — 34.5; 38.6 units on a scale — p=.111
Phase 3 N=114 Diazepam Use With Standard Management for Acute Low Back Pain
Low Back Pain
Primary: Change in Functional Impairment as Measured by the Roland Morris Disability Questionnaire — 11; 11 units on a scale