Phase 2 N=18 Early Insulin and Development of ARDS
Respiratory Distress Syndrome, Adult · Sepsis · Hyperglycemia
Primary: Plasma Levels of Free Fatty Acids, Tumor Necrosis Factor-α, Interleukin-6, and Von Willebrand Factor Antigen
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=120 Treatment of Critical Illness Polyneuromyopathy
Acute Respiratory Failure
Primary: The Primary Outcome Variable for This Study Will be the Short Form of the Continuous Scale Physical Functional Performance Test (CS-PFP) Called the PFP-10 — 19.0; 20.9…
N/A N=29 Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease
Amyotrophic Lateral Sclerosis (ALS) · Neuromuscular Diseases
Primary: Percent Change in Maximal Inspiratory Pressure (MIP) — 0.3; -3.1; -4.8; -5.0 percentage change in MIP from baseline
N/A N=248 Aspiration in Acute Respiratory Failure Survivors
Dysphagia
Primary: Percentage of Participants Experiencing Aspiration — 70; 52 percentage of participants
Phase 2 N=6 Extracorporeal Membrane Oxygenation (ECMO) in Non-intubated Patients With Acute Respiratory Distress Syndrome (ARDS)
ARDS
Primary: Number of Participants That Did Not Require Endotrachael Intubation — 3 participants
N/A N=50 Extracorporeal Lung Assist to Avoid Intubation in Patients Failing Noninvasive Ventilation for Hypercapnic ARF
Hypercapnia · Respiratory Insufficiency
Primary: Number of Patients With Need for Intubation for Invasive Mechanical Ventilation — 11; 25 Participants
N/A N=1,705 ED Lung Protective Ventilation to Reduce Complications
Mechanical Ventilation · Ventilator-associated Conditions · ARDS
Primary: Number of Patients That Experience Pulmonary Complications After Admission From the Emergency Department — 171; 38 participants
N/A N=219 Mechanical Ventilation in the Emergency Department: A Prospective Cross-Sectional Study
Respiratory Failure · Mechanical Ventilation · Acute Lung Injury
Primary: To Further Characterize ED Mechanical Ventilation — 500 mL
Phase 4 N=129 Non Invasive Mechanical Ventilation in Acute Cardiogenic Pulmonary Edema
Acute Cardiogenic Pulmonary Edema
Primary: Number of Patients Who Were Intubated — 5; 4; 10 participants
N/A N=13 Electrical Impedance Tomography (EIT) Monitoring in Adults With ALI or ARDS
Acute Lung Injury (ALI) · ARDS
Primary: Feasibility of EIT Monitoring in This Population of ARDS/ALI Patients — 13 Patients successfully monitored with EIT
N/A N=16 Electrical Impedance Tomography for Optimization of Positive End-Expiratory Pressure: Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome · ARDS
Primary: Mechanical Power — 1.87; -2.50 J/min — p=.002
N/A N=320 Intensive Alveolar Recruitment Protocol After Cardiac Surgery
Ventilator Induced Lung Injury · Cardiac Disease · Acute Lung Injury
Primary: Severity of Pulmonary Complications in the Post-operative Period — 15; 26 percentage of participants — p=0.016
N/A N=52 Extubation Readiness and Neuroventilatory Efficiency After Acute Respiratory Failure
Respiratory Failure
Primary: Neuroventilatory Efficiency (NVE) — 17.6; 39.9 ml/uV — p=<0.05
N/A N=524 Sigh Ventilation to Increase Ventilator-Free Days in Victims of Trauma at Risk for Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome
Primary: Ventilator-free Days (VFDs) — 18.4; 16.1 days
N/A N=30 In-home Evaluation of a Noninvasive Open Ventilation System in Patients With Severe Respiratory Insufficiency
Pulmonary Disease, Chronic Obstructive · Airflow Obstruction, Chronic · Chronic Obstructive Airway Disease
Primary: Activity Endurance Time — 7.24; 13.38 minutes — p=<0.05
N/A N=15 Acute Effect of Ventilatory Support During Exercise in Spinal Cord Injury
Spinal Cord Injury
Primary: Change in Peak Aerobic Capacity During FES-row Testing — 1.83; 1.82 L/min
Phase 3 N=52 Nitric Oxide Administration for Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome
Primary: Mean PaO2/FiO2 Ratio — 115.6; 115.9 mmHg — p=>0.05
N/A N=60 Evaluation Of The Total Face Mask For Emergency Application In Acute Respiratory Failure
Acute Respiratory Insufficiency
Primary: Mask Comfort (as Determined by the Visual Analog Scores 1 Being Least, 10 Being Most) — 3.2; 3.3 units on a scale
N/A N=139 The Role of Circulating Soluble CD74 in Acute Lung Injury
Acute Lung Injury · Acute Respiratory Distress Syndrome
Primary: Number of Participants Receiving Mechanical Ventilation — 51; NA participants
N/A N=55 External Nasal Dilator and Oxygen Therapy in Respiratory Failure
Acute Respiratory Failure
Primary: Change of Respiratory Status Using the Modified Bronchiolitis Severity Score, in Children Using External Nasal Dilators as an Adjuvant to High Flow Nasal Cannula Oxygen…
Phase 2 N=165 Lucinactant for Treatment of Acute Hypoxemic Respiratory Failure in Children up to Two Years Old
Acute Hypoxemic Respiratory Failure
Primary: Duration of Mechanical Ventilation Through 14 Days — 4.0; 4.5 days
N/A N=466 Mobile Critical Care Recovery Program for Acute Respiratory Failure Survivors
Acute Respiratory Failure · Post-Intensive Care Syndrome
Primary: Self Reported Quality of Life PCS: Physical Component Score at 1 Year — 36.22; 35.29 score on a scale
N/A N=6 Assessment of End Expiratory Lung Volumes in Healthy Subjects Using High Flow Oxygen (Vapotherm®)
Healthy Adult Volunteers
Primary: Change in End-expiratory Lung Volume — -144; 103 mL
N/A N=52 Behavioral Activation-Rehabilitation to Improve Depressive Symptoms & Physical Function After Acute Respiratory Failure
Respiratory Insufficiency · Depression · Rehabilitation
Primary: Feasibility Measure Per Participant — 0.8 proportion of intended visits
Phase 2 N=5 The Safety, Tolerability, PK and PD of GSK2586881 in Patients With Acute Lung Injury
Lung Injury, Acute
Primary: Heart Rate Assessments Upto Day 7 (Part B) — 87.4; 97.7; 87.9; 95.3 Beats per minute
N/A N=751 Protocolized Post-Extubation Respiratory Support Study
Mechanical Ventilation Complication · Acute Respiratory Failure · Intubation Complication
Primary: Reintubation — 57; 52 Participants
Phase 3 N=203 Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure
Critical COVID-19 With Respiratory Failure · Acute Respiratory Distress Syndrome (ARDS) · Corona Virus Infection
Primary: Resolution of Respiratory Failure (Alive and Free of Respiratory Failure) — 72; 33 Participants
Phase 3 N=10 Validation of the AVAPS AE Algorithm in Chronic Obstructive Pulmonary Disease (COPD) Patients
COPD · OSA
Primary: Control of Nocturnal Hypoventilation — 6.5; 6.7 kPa
Phase 2 N=200 Nitric Oxide Gas Inhalation in Severe Acute Respiratory Syndrome in COVID-19
SARS (Severe Acute Respiratory Syndrome) · Coronavirus
Primary: Change of Arterial Oxygenation at 48 Hours From Enrollment — 200; 183 ratio
Phase 2 N=149 Aerosolized Surfactant in Neonatal RDS
Respiratory Distress Syndrome, Newborn
Primary: Number of Participants With Adverse Events as a Measure of Safety and Feasibility — 3; 8; 4; 12 Participants