N/A N=58 Cranial Electrotherapy Stimulation and Acute Stress
Anxiety State
Primary: Change From Baseline in Heart Rate During Stressful Lethal Force Decision Making Task — 98.5; 111; 100.0; 114 bpm — p=.012
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=170 Stressor-evoked Brain and Cardiovascular Responses to Acute Psychological Stress
Acute Psychological Stress
Primary: Stressor-evoked Oxygen Consumption in mL/(kg·Min) (Stress - Baseline) — 0.265; 0.287 mL/(kg·min)
Phase 2 N=65 Explorative Open Label Study of Efficacy Profile of Neurexan® in Experimental Acute Stress Setting in Healthy Subjects
Acute Stress Reaction
Primary: Acute Stress Measured by Tension — 3089.4; 3253.4 mm*min — p=0.1233
N/A N=1,418 Effects of Arousal and Stress in Anxiety
Healthy Volunteers
Primary: Go Correct Hits Followed by Button Press — 90.9; 91.6 Percentage of correct responses
N/A N=91 Cortisol Suppression and Startle Responses in Posttraumatic Stress Disorder (PTSD)
Post Traumatic Stress Disorder
Primary: Mean Baseline Startle Magnitude During Fear Conditioning — 48.401; 56.595; 115.778; 57.684 microvolts
N/A N=28 Resolving Psychological Stress
Post-Traumatic Stress Disorder · Alcohol Use Disorder
Primary: PTSD Symptoms Using PTSD Checklist-5 (PCL-5) at Baseline and 15 Days — 33.2; 36.6; 31.2; 28.2 units on a scale — p=0.322
Phase 3 N=80 Post Traumatic Stress Disorder (PTSD) Hyperarousal Symptoms Treated With Physiological Stress Management
Stress Disorders, Post-Traumatic
Primary: Change Scores for Criteria D Items on the CAPS Structured Clinical Interview — -1.20; -6.27 units on a scale — p=.27
Phase 2 N=66 Explorative Efficacy Profile of Neurexan® in an Experimental Acute Stress Setting in Healthy Subjects
Acute Stress Reaction
Primary: Acute Stress Measured by Tension — 3335.7; 3360.3 mm*min — p=0.7726
Phase 2 N=245 Prevention of Post Sexual Assault Stress
Drug Use · Drug Abuse · Posttraumatic Stress Disorder
Primary: Drug Abuse Screening Test (DAST-10) — 1.97; 2.03; 1.18 units on a scale — p=.24
Phase 3 N=60 Pilot Study on the Efficacy of Pascoflair in an Acute Stressful Situation (TSST)
Healthy · Stress
Primary: VAS Insecurity (During) — 56.87; 60.93 mm
N/A N=23 Stress and the Nervous System
Autonomic Nervous System · Baroreflex · Stress, Physiological
Primary: Cardiovagal Baroreflex Sensitivity (Modified Oxford Technique) — 17.75; 16.90; 14.42; 17.27 ms/mmHg
Phase 4 N=43 Effect of Propranolol on Preventing Posttraumatic Stress Disorder
Post-Traumatic Stress Disorder
Primary: Physiological Posterior Probability of Posttraumatic Stress Disorder (PTSD) as Determined From Psychophysiologic Responses During Script-Driven Mental Imagery at Month 1…
N/A N=57 Brief Restructuring Intervention Following Trauma Exposure
Posttraumatic Stress Disorder · Alcohol Use Disorders
Primary: Posttraumatic Stress Disorder Symptom Scale- Interview Version (PSS-I) — 11.4; 22.1 score on a scale
Phase 4 N=106 Veteran Stress and Learning Study
Stress Disorders, Posttraumatic
Primary: Proportion of Maximum Skin Conductance Response (SCR) in Microsiemens (µS) — .0325522; .0245775; -.0181339; .1233174 proportion of max SCR (µS) — p==.66
N/A N=139 Prevention of Post-traumatic Stress Disorder by Telephone Based Cognitive Behavioral Therapy
Stress Disorder - Post-traumatic (Acute)
Primary: Severity of PTSD Symptoms — 43.4; 43.9 CAPS total Score at treatment end — p=0.927
N/A N=72 Biological Response to Brief Psychological Challenge
Acute Inflammatory Response to Psychological Stress
Primary: Cell-free Mitochondrial DNA — 165.79; 405.56; 175.45; 164.45 Copies per uL — p=0.86
N/A N=94 Stress and the Sympathetic Nervous System in Adults With Depression
Major Depressive Disorder
Primary: Percent of Days Participants Report Stressors — 36; 40 percent of days
N/A N=169 Brief Treatment for Posttraumatic Stress Disorder
PTSD
Primary: Clinician Administered PTSD Scale, 5 (CAPS-5) — 31.55; 25.12; 29.59; 25.41 score on a scale
N/A N=93 Recovery After Stress Toolkit (RESET) Study
Post-Traumatic Stress Disorder in Children · Post-Traumatic Stress Disorder in Adolescence
Primary: Child PTSD Symptom Scale (CPSS) — 10.4; 14 Score on a scale
N/A N=112 The Effect of Reducing Posttraumatic Stress Disorder Symptoms on Cardiovascular Risk
PTSD
Primary: Change From Baseline to Post-Intervention in 24-hour Heart Rate Variability (HRV) Estimated From the Standard Deviation of the Interbeat Interval of Normal Sinus Beats…
N/A N=119 Stress Response in Opioid Use Disorder
Opioid-use Disorder
Primary: Change in Negative Affect — 1.67; 1.25; 3.60 scores on a scale
Phase 2 N=61 Testing Doxazosin to Treat Stress Mechanisms in Alcoholism
Alcoholism
Primary: Startle Potentiation During Stress Reactivity Task — 22.25; 20.76; 26.22; 22.21 microvolts
N/A N=32 HIRREM in Military Personnel
Stress Disorders, Post-Traumatic
Primary: Change in PCL-M Score From Baseline to 12 Days — -12.88 score on a scale
N/A N=97 Influence of Stress on Encoding and Prediction
Stress · Learning, Spatial
Primary: Changes in fMRI Signal — 0.261; -0.264 Pearson's rho — p=0.023
N/A N=103 Novel Treatment of Emotional Dysfunction in Post Traumatic Stress Disorder (PTSD)
Post Traumatic Stress Disorder
Primary: Change From Baseline to Follow-up in Clinician Administered Post-Traumatic Stress Disorder Scale Total Severity Score — -35.59; -44.164; -33.19; -44.95 change in scale…
Phase 4 N=23 A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation Propranolol
Posttraumatic Stress Disorder
Primary: Physiological Posterior Probability of Posttraumatic Stress Disorder (PTSD) as Determined From Psychophysiologic Responses During Script-Driven Traumatic Memory…
Phase 4 N=84 Stress & Premenstrual Symptoms Study
PMDD · Stress · Mood
Primary: Acoustic Startle Response (ASR) Magnitude Based on Menstrual Cycle Phase — 54.2; 53.7; 56.4; 53.3 t score — p=0.139
N/A N=120 Adolescent Trauma Recovery and Stress Disorders Collaborative Care (ATRSCC) Model Program Trial
Post-traumatic Stress Disorder · Alcohol Abuse · Alcohol Dependence
Primary: Number of Patients With High Levels of Adolescent PTSD Symptoms — 9; 12; 11; 12 Participants — p=0.71
N/A N=46 Morning Light Treatment for Traumatic Stress: The Role of Amygdala Reactivity
Stress
Primary: Change in Amygdala Reactivity as Measured by Blood-oxygen-level-dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Signal — 0.1287; 0.1532; 0.2134; 0.1048…
N/A N=60 RCT for Innovating Stress-related eHealth
Posttraumatic Stress Disorder · Sexual Assault · Pain
Primary: Treatment Adherence/Acceptability Scale — 57.53 score on a scale